DegronMD

Uniprot ID: O60566

Source protein: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Source gene: BUB1B

Class: DEG_APCC_KENBOX_2

Location: 25:29

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.997

ASA_SCORE: 60.38

COIL: 0.6812

CONS_SCORE: 0.6626

DSS_SCORE: 0.4843

HELIX: 0.2538

FCONS_SCORE: 1.4604

RIG_SCORE: 0.776

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V29E	TCGA-AX-A2H5	UCEC	TCGA	SKENV	DEG_APCC_KENBOX_2	0.6582
p.V29E	DO41157	UCEC	ICGC	SKENV	DEG_APCC_KENBOX_2	0.6582
p.E27K	DO1076	BRCA	ICGC	SKENV	DEG_APCC_KENBOX_2	0.7022
p.R33S	DO229028	LICA	ICGC	SKENV	DEG_APCC_KENBOX_2	0.2222
p.M38I	DO229032	LICA	ICGC	SKENV	DEG_APCC_KENBOX_2	0.0833
p.E23K	DO50970	LICA	ICGC	SKENV	DEG_APCC_KENBOX_2	0.2778
p.I37M	DO27879	ORCA	ICGC	SKENV	DEG_APCC_KENBOX_2	0.1111
p.Q34H	SIDM00241	Breast Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	0.1944
p.Q34H	ACH-002179	Breast Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	0.1944
p.Q34H	OCUB-M	breast	COSMIC	SKENV	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	DEG_APCC_KENBOX_2	25:29	SKENV	APC,CDC20,FZR1	0.997	More...
Q58F21	Bromodomain testis-specific protein	DEG_APCC_KENBOX_2	683:687	SKENV	APC,CDC20,FZR1	0.9942	More...
Q6ZU35	Capping protein-inhibiting regulator of actin dynamics	DEG_APCC_KENBOX_2	1123:1127	SKENV	APC,CDC20,FZR1	0.7191	More...
Q8NI27	THO complex subunit 2	DEG_APCC_KENBOX_2	1375:1379	SKENV	APC,CDC20,FZR1	0.5524	More...
Q8TBA6	Golgin subfamily A member 5	DEG_APCC_KENBOX_2	198:202	SKENV	APC,CDC20,FZR1	0.9905	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_APCC_KENBOX_2	1525:1529	SKENV	APC,CDC20,FZR1	0.8967	More...
O95625	Zinc finger and BTB domain-containing protein 11	DEG_APCC_KENBOX_2	442:446	SKENV	APC,CDC20,FZR1	0.9903	More...
Q2T9K0	Transmembrane protein 44	DEG_APCC_KENBOX_2	450:454	SKENV	APC,CDC20,FZR1	0.6922	More...
Q8N9V7	Protein TOPAZ1	DEG_APCC_KENBOX_2	731:735	SKENV	APC,CDC20,FZR1	0.8214	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons