DegronMD - Q2T9K0(TMEM44)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G403R	TCGA-A6-4105	COAD	TCGA	PPSY	ITCH	410:413	Mutation rewiring degron network	0.1389
p.S412L	TCGA-AA-A00N	COAD	TCGA	PPSY	ITCH	410:413	Mutation altering degron motif	0.6556
p.S401R	TCGA-AD-A5EJ	COAD	TCGA	PPSY	ITCH	410:413	Mutation rewiring degron network	0.0833
p.Q408H	TCGA-NH-A5IV	COAD	TCGA	PPSY	ITCH	410:413	Mutation rewiring degron network	0.2778
p.V407A	DO1243	BRCA	ICGC	PPSY	ITCH	410:413	Mutation rewiring degron network	0.25
p.S401L	DO28080	OV	ICGC	PPSY	ITCH	410:413	Mutation rewiring degron network	0.0833
p.R420W	SIDM00458	Acute Myeloid Leukemia	GDSC	PPSY	ITCH	410:413	Mutation rewiring degron network	0.1389
p.L457V	SIDM00333	Endometrial Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	450:454	Mutation rewiring degron network	0.25
p.L457V	ACH-000988	Endometrial/Uterine Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	450:454	Mutation rewiring degron network	0.25
p.L457V	MFE-319	endometrium	COSMIC	SKENV	DEG_APCC_KENBOX_2	450:454	Mutation rewiring degron network	0.25
p.S412W	SIDM00888	Other Solid Cancers	GDSC	PPSY	ITCH	410:413	Mutation altering degron motif	0.6763
p.V416I	SIDM00172	Head and Neck Carcinoma	GDSC	PPSY	ITCH	410:413	Mutation rewiring degron network	0.25
p.E448K	SIDM01582	Gastric Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	450:454	Mutation rewiring degron network	0.2778
p.E448K	ACH-000507	Gastric Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	450:454	Mutation rewiring degron network	0.2778
p.L410V	MFE-319	endometrium	COSMIC	PPSY	ITCH	410:413	Mutation altering degron motif	0.6765
p.L420V	MFE-319	endometrium	COSMIC	PPSY	ITCH	410:413	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons