DegronMD

Uniprot ID: Q2T9K0

Source protein: Transmembrane protein 44

Source gene: TMEM44

Class: DEG_APCC_KENBOX_2

Location: 450:454

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6922

ASA_SCORE: 86.7

COIL: 0.6062

CONS_SCORE: 0.2944

DSS_SCORE: 0.5644

HELIX: 0.2878

FCONS_SCORE: 0.6913

RIG_SCORE: 0.7182

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L457V	SIDM00333	Endometrial Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	0.25
p.L457V	ACH-000988	Endometrial/Uterine Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	0.25
p.L457V	MFE-319	endometrium	COSMIC	SKENV	DEG_APCC_KENBOX_2	0.25
p.E448K	SIDM01582	Gastric Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	0.2778
p.E448K	ACH-000507	Gastric Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	DEG_APCC_KENBOX_2	25:29	SKENV	APC,CDC20,FZR1	0.997	More...
Q58F21	Bromodomain testis-specific protein	DEG_APCC_KENBOX_2	683:687	SKENV	APC,CDC20,FZR1	0.9942	More...
Q6ZU35	Capping protein-inhibiting regulator of actin dynamics	DEG_APCC_KENBOX_2	1123:1127	SKENV	APC,CDC20,FZR1	0.7191	More...
Q8NI27	THO complex subunit 2	DEG_APCC_KENBOX_2	1375:1379	SKENV	APC,CDC20,FZR1	0.5524	More...
Q8TBA6	Golgin subfamily A member 5	DEG_APCC_KENBOX_2	198:202	SKENV	APC,CDC20,FZR1	0.9905	More...
Q9NR99	Matrix-remodeling-associated protein 5	DEG_APCC_KENBOX_2	1525:1529	SKENV	APC,CDC20,FZR1	0.8967	More...
O95625	Zinc finger and BTB domain-containing protein 11	DEG_APCC_KENBOX_2	442:446	SKENV	APC,CDC20,FZR1	0.9903	More...
Q2T9K0	Transmembrane protein 44	DEG_APCC_KENBOX_2	450:454	SKENV	APC,CDC20,FZR1	0.6922	More...
Q8N9V7	Protein TOPAZ1	DEG_APCC_KENBOX_2	731:735	SKENV	APC,CDC20,FZR1	0.8214	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons