DegronMD - O60566(BUB1B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A332T	TCGA-A5-A0G1	UCEC	TCGA	PSFTPYVE	DEG_SCF_FBW7_2	338:345	Mutation rewiring degron network	0.1667
p.A332T	TCGA-A5-A0G1	UCEC	TCGA	FTPYVE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.1111
p.A332T	DO42472	UCEC	ICGC	PSFTPYVE	DEG_SCF_FBW7_2	338:345	Mutation rewiring degron network	0.1667
p.A332T	DO42472	UCEC	ICGC	FTPYVE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.1111
p.S521Y	TCGA-A5-A0G2	UCEC	TCGA	FSIFDE	LIG_APCC_ABBA_1	528:533	Mutation blocking phosphorylation signal	0.5833
p.S521Y	DO41235	UCEC	ICGC	FSIFDE	LIG_APCC_ABBA_1	528:533	Mutation blocking phosphorylation signal	0.5833
p.L308P	TCGA-AA-3949	COAD	TCGA	AKENE	DEG_APCC_KENBOX_2	303:307	Mutation rewiring degron network	0.3056
p.L308P	DO7798	COAD	ICGC	AKENE	DEG_APCC_KENBOX_2	303:307	Mutation rewiring degron network	0.3056
p.V29E	TCGA-AX-A2H5	UCEC	TCGA	SKENV	DEG_APCC_KENBOX_2	25:29	Mutation altering degron motif	0.6582
p.V29E	DO41157	UCEC	ICGC	SKENV	DEG_APCC_KENBOX_2	25:29	Mutation altering degron motif	0.6582
p.D572Y	TCGA-AX-A2HC	UCEC	TCGA	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation rewiring degron network	0.0556
p.R550Q	TCGA-BR-8078	STAD	TCGA	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation rewiring degron network	0.2222
p.R550Q	TCGA-EO-A22U	UCEC	TCGA	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation rewiring degron network	0.2222
p.E705D	TCGA-BS-A0UF	UCEC	TCGA	VASTS	DEG_SPOP_SBC_1	692:696	Mutation rewiring degron network	0.0833
p.E705K	TCGA-C4-A0F1	BLCA	TCGA	VASTS	DEG_SPOP_SBC_1	692:696	Mutation rewiring degron network	0.0833
p.S220C	TCGA-CU-A3YL	BLCA	TCGA	QRSTLAELK	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.25
p.S220C	DO834	BLCA	ICGC	QRSTLAELK	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.25
p.P524L	TCGA-D3-A3CB	SKCM	TCGA	FSIFDE	LIG_APCC_ABBA_1	528:533	Mutation rewiring degron network	0.2222
p.P241A	TCGA-D8-A73U	BRCA	TCGA	QRSTLAELK	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.0556
p.P241A	DO219629	BRCA	ICGC	QRSTLAELK	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.0556
p.P704S	TCGA-EE-A29E	SKCM	TCGA	VASTS	DEG_SPOP_SBC_1	692:696	Mutation rewiring degron network	0.1111
p.R555Q	TCGA-EO-A22R	UCEC	TCGA	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation altering degron motif	0.7329
p.R271I	TCGA-EO-A22X	UCEC	TCGA	RITVFDE	LIG_APCC_ABBAyCdc20_2	271:277	Mutation altering degron motif	0.8102
p.R271I	DO43907	UCEC	ICGC	RITVFDE	LIG_APCC_ABBAyCdc20_2	271:277	Mutation altering degron motif	0.8102
p.P222Q	TCGA-ER-A19B	SKCM	TCGA	QRSTLAELK	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.3056
p.P222Q	DO47491	SKCM	ICGC	QRSTLAELK	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.3056
p.R302G	TCGA-FI-A2D5	UCEC	TCGA	AKENE	DEG_APCC_KENBOX_2	303:307	Mutation rewiring degron network	0.3056
p.R302G	DO41331	UCEC	ICGC	AKENE	DEG_APCC_KENBOX_2	303:307	Mutation rewiring degron network	0.3056
p.P241T	TCGA-FS-A1ZM	SKCM	TCGA	QRSTLAELK	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.0556
p.P241T	DO37731	SKCM	ICGC	QRSTLAELK	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.0556
p.P544S	TCGA-FW-A3R5	SKCM	TCGA	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation rewiring degron network	0.0556
p.P544S	SIDM00957	Colorectal Carcinoma	GDSC	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation rewiring degron network	0.0556
p.P544S	SIDM00698	Small Cell Lung Carcinoma	GDSC	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation rewiring degron network	0.0556
p.P544S	NCI-H146	lung	COSMIC	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation rewiring degron network	0.0556
p.P544S	COLO-678	large intestine	COSMIC	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation rewiring degron network	0.0556
p.S689F	TCGA-W3-A825	SKCM	TCGA	VASTS	DEG_SPOP_SBC_1	692:696	Mutation rewiring degron network	0.25
p.R349Q	DO228483	BRCA	ICGC	PSFTPYVE	DEG_SCF_FBW7_2	338:345	Mutation rewiring degron network	0.2222
p.R349Q	DO228483	BRCA	ICGC	FTPYVE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.2222
p.R349Q	DO230334	COCA	ICGC	PSFTPYVE	DEG_SCF_FBW7_2	338:345	Mutation rewiring degron network	0.2222
p.R349Q	DO230334	COCA	ICGC	FTPYVE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.2222
p.R349Q	DO227999	COCA	ICGC	PSFTPYVE	DEG_SCF_FBW7_2	338:345	Mutation rewiring degron network	0.2222
p.R349Q	DO227999	COCA	ICGC	FTPYVE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.2222
p.R349Q	DO229016	COCA	ICGC	PSFTPYVE	DEG_SCF_FBW7_2	338:345	Mutation rewiring degron network	0.2222
p.R349Q	DO229016	COCA	ICGC	FTPYVE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.2222
p.R349Q	DO234285	ESAD	ICGC	PSFTPYVE	DEG_SCF_FBW7_2	338:345	Mutation rewiring degron network	0.2222
p.R349Q	DO234285	ESAD	ICGC	FTPYVE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.2222
p.R349Q	DO229489	LAML	ICGC	PSFTPYVE	DEG_SCF_FBW7_2	338:345	Mutation rewiring degron network	0.2222
p.R349Q	DO229489	LAML	ICGC	FTPYVE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.2222
p.R349Q	DO228941	LICA	ICGC	PSFTPYVE	DEG_SCF_FBW7_2	338:345	Mutation rewiring degron network	0.2222
p.R349Q	DO228941	LICA	ICGC	FTPYVE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.2222
p.E218Q	DO1076	BRCA	ICGC	QRSTLAELK	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.1944
p.E27K	DO1076	BRCA	ICGC	SKENV	DEG_APCC_KENBOX_2	25:29	Mutation altering degron motif	0.7022
p.L683P	DO44170	BRCA	ICGC	VASTS	DEG_SPOP_SBC_1	692:696	Mutation blocking phosphorylation signal	0.5278
p.M266I	DO228952	LICA	ICGC	ITVFDE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.1667
p.M266I	DO228952	LICA	ICGC	RITVFDE	LIG_APCC_ABBAyCdc20_2	271:277	Mutation rewiring degron network	0.1944
p.A335S	DO229015	LICA	ICGC	PSFTPYVE	DEG_SCF_FBW7_2	338:345	Mutation rewiring degron network	0.25
p.A335S	DO229015	LICA	ICGC	FTPYVE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.1944
p.R33S	DO229028	LICA	ICGC	SKENV	DEG_APCC_KENBOX_2	25:29	Mutation rewiring degron network	0.2222
p.G316C	DO229028	LICA	ICGC	AKENE	DEG_APCC_KENBOX_2	303:307	Mutation rewiring degron network	0.0833
p.M38I	DO229032	LICA	ICGC	SKENV	DEG_APCC_KENBOX_2	25:29	Mutation rewiring degron network	0.0833
p.S225I	DO229037	LICA	ICGC	QRSTLAELK	DEG_APCC_DBOX_1	223:231	Mutation altering degron motif	0.623
p.E23K	DO50970	LICA	ICGC	SKENV	DEG_APCC_KENBOX_2	25:29	Mutation rewiring degron network	0.2778
p.V336L	DO23452	LINC	ICGC	PSFTPYVE	DEG_SCF_FBW7_2	338:345	Mutation rewiring degron network	0.2778
p.V336L	DO23452	LINC	ICGC	FTPYVE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.2222
p.P562S	DO23370	LINC	ICGC	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation altering degron motif	0.6752
p.R691H	DO25183	LUAD	ICGC	VASTS	DEG_SPOP_SBC_1	692:696	Mutation rewiring degron network	0.3056
p.R691H	SW1783	central nervous system	COSMIC	VASTS	DEG_SPOP_SBC_1	692:696	Mutation rewiring degron network	0.3056
p.S684R	DO228343	MALY	ICGC	VASTS	DEG_SPOP_SBC_1	692:696	Mutation rewiring degron network	0.1111
p.I37M	DO27879	ORCA	ICGC	SKENV	DEG_APCC_KENBOX_2	25:29	Mutation rewiring degron network	0.1111
p.I687S	DO232224	PBCA	ICGC	VASTS	DEG_SPOP_SBC_1	692:696	Mutation rewiring degron network	0.1944
p.P558S	DO37406	SKCM	ICGC	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation altering degron motif	0.6752
p.P558S	NCI-H146	lung	COSMIC	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation altering degron motif	0.6752
p.P558S	COLO-678	large intestine	COSMIC	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation altering degron motif	0.6752
p.P538L	DO47386	SKCM	ICGC	FSIFDE	LIG_APCC_ABBA_1	528:533	Mutation rewiring degron network	0.1944
p.S703F	DO51272	SKCM	ICGC	VASTS	DEG_SPOP_SBC_1	692:696	Mutation rewiring degron network	0.1389
p.R564Q	DO38288	STAD	ICGC	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation rewiring degron network	0.2778
p.R564Q	DO43755	UCEC	ICGC	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation rewiring degron network	0.2778
p.F542S	DO229248	THCA	ICGC	FSIFDE	LIG_APCC_ABBA_1	528:533	Mutation blocking ubiquitination signal	0.5278
p.R569Q	DO42713	UCEC	ICGC	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation rewiring degron network	0.1389
p.P334L	SIDM00646	Small Cell Lung Carcinoma	GDSC	PSFTPYVE	DEG_SCF_FBW7_2	338:345	Mutation rewiring degron network	0.2222
p.P334L	SIDM00646	Small Cell Lung Carcinoma	GDSC	FTPYVE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.1667
p.P334L	SIDM00519	Mesothelioma	GDSC	PSFTPYVE	DEG_SCF_FBW7_2	338:345	Mutation rewiring degron network	0.2222
p.P334L	SIDM00519	Mesothelioma	GDSC	FTPYVE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.1667
p.P545S	SIDM00545	Melanoma	GDSC	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation rewiring degron network	0.0833
p.P545S	ACH-000987	Skin Cancer	CCLE	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation rewiring degron network	0.0833
p.P545S	Mewo	skin	COSMIC	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation rewiring degron network	0.0833
p.P351S	SIDM01175	Other Sarcomas	GDSC	PSFTPYVE	DEG_SCF_FBW7_2	338:345	Mutation rewiring degron network	0.1667
p.P351S	SIDM01175	Other Sarcomas	GDSC	FTPYVE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.1667
p.P351S	ACH-002309	Sarcoma	CCLE	PSFTPYVE	DEG_SCF_FBW7_2	338:345	Mutation rewiring degron network	0.1667
p.P351S	ACH-002309	Sarcoma	CCLE	FTPYVE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.1667
p.P351S	SW684	soft tissue	COSMIC	PSFTPYVE	DEG_SCF_FBW7_2	338:345	Mutation rewiring degron network	0.1667
p.P351S	SW684	soft tissue	COSMIC	FTPYVE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.1667
p.S521F	SIDM00963	Breast Carcinoma	GDSC	FSIFDE	LIG_APCC_ABBA_1	528:533	Mutation blocking phosphorylation signal	0.5833
p.S521F	ACH-000927	Breast Cancer	CCLE	FSIFDE	LIG_APCC_ABBA_1	528:533	Mutation blocking phosphorylation signal	0.5833
p.S521F	BT-474	breast	COSMIC	FSIFDE	LIG_APCC_ABBA_1	528:533	Mutation blocking phosphorylation signal	0.5833
p.Q34H	SIDM00241	Breast Carcinoma	GDSC	SKENV	DEG_APCC_KENBOX_2	25:29	Mutation rewiring degron network	0.1944
p.Q34H	ACH-002179	Breast Cancer	CCLE	SKENV	DEG_APCC_KENBOX_2	25:29	Mutation rewiring degron network	0.1944
p.Q34H	OCUB-M	breast	COSMIC	SKENV	DEG_APCC_KENBOX_2	25:29	Mutation rewiring degron network	0.1944
p.S543I	SIDM00079	Ovarian Carcinoma	GDSC	FSIFDE	LIG_APCC_ABBA_1	528:533	Mutation blocking phosphorylation signal	0.5
p.S543I	SK-OV-3	ovary	COSMIC	FSIFDE	LIG_APCC_ABBA_1	528:533	Mutation blocking phosphorylation signal	0.5
p.S691L	SIDM01018	Hodgkin's Lymphoma	GDSC	VASTS	DEG_SPOP_SBC_1	692:696	Mutation rewiring degron network	0.3056
p.S691L	ACH-000815	Lymphoma	CCLE	VASTS	DEG_SPOP_SBC_1	692:696	Mutation rewiring degron network	0.3056
p.S691L	KM-H2	haematopoietic and lymphoid tissue	COSMIC	VASTS	DEG_SPOP_SBC_1	692:696	Mutation rewiring degron network	0.3056
p.N570H	SIDM01611	Endometrial Carcinoma	GDSC	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation rewiring degron network	0.1111
p.N570H	ACH-000996	Endometrial/Uterine Cancer	CCLE	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation rewiring degron network	0.1111
p.A335V	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PSFTPYVE	DEG_SCF_FBW7_2	338:345	Mutation rewiring degron network	0.25
p.A335V	SIDM01618	B-Lymphoblastic Leukemia	GDSC	FTPYVE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.1944
p.A335V	ACH-000942	Leukemia	CCLE	PSFTPYVE	DEG_SCF_FBW7_2	338:345	Mutation rewiring degron network	0.25
p.A335V	ACH-000942	Leukemia	CCLE	FTPYVE	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.1944
p.N268D	ACH-000911	Gastric Cancer	CCLE	ITVFDE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.2222
p.N268D	ACH-000911	Gastric Cancer	CCLE	RITVFDE	LIG_APCC_ABBAyCdc20_2	271:277	Mutation rewiring degron network	0.25
p.I272L	ACH-000993	Endometrial/Uterine Cancer	CCLE	ITVFDE	LIG_APCC_ABBA_1	272:277	Mutation altering degron motif	0.6063
p.I272L	ACH-000993	Endometrial/Uterine Cancer	CCLE	RITVFDE	LIG_APCC_ABBAyCdc20_2	271:277	Mutation altering degron motif	0.6063
p.P294Q	ACH-001061	Colon/Colorectal Cancer	CCLE	AKENE	DEG_APCC_KENBOX_2	303:307	Mutation rewiring degron network	0.0833
p.S535F	BT-474	breast	COSMIC	FSIFDE	LIG_APCC_ABBA_1	528:533	Mutation rewiring degron network	0.2778
p.S684I	IM-95	stomach	COSMIC	VASTS	DEG_SPOP_SBC_1	692:696	Mutation rewiring degron network	0.1111
p.P559S	Mewo	skin	COSMIC	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation altering degron motif	0.6752
p.S557I	SK-OV-3	ovary	COSMIC	QRRPLAVLK	DEG_APCC_DBOX_1	554:562	Mutation altering degron motif	0.7341
p.I686S	HT-115	large intestine	COSMIC	VASTS	DEG_SPOP_SBC_1	692:696	Mutation rewiring degron network	0.1667
p.R213P	SNU-182	liver	COSMIC	QRSTLAELK	DEG_APCC_DBOX_1	223:231	Mutation rewiring degron network	0.0556
p.S705L	KM-H2	haematopoietic and lymphoid tissue	COSMIC	VASTS	DEG_SPOP_SBC_1	692:696	Mutation rewiring degron network	0.0833
p.H695P	OVKATE	ovary	COSMIC	VASTS	DEG_SPOP_SBC_1	692:696	Mutation altering degron motif	0.7694

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BUB1B

UniProt ID: O60566

Entrez ID: 701

Protein name: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BUB1B in