DegronMD

Uniprot ID: O60566

Source protein: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Source gene: BUB1B

Class: LIG_APCC_ABBA_1

Location: 340:345

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9646

ASA_SCORE: 78.4333

COIL: 0.7365

CONS_SCORE: 0.2417

DSS_SCORE: 0.3338

HELIX: 0.146

FCONS_SCORE: 0.8128

RIG_SCORE: 0.7895

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A332T	TCGA-A5-A0G1	UCEC	TCGA	FTPYVE	LIG_APCC_ABBA_1	0.1111
p.A332T	DO42472	UCEC	ICGC	FTPYVE	LIG_APCC_ABBA_1	0.1111
p.R349Q	DO228483	BRCA	ICGC	FTPYVE	LIG_APCC_ABBA_1	0.2222
p.R349Q	DO230334	COCA	ICGC	FTPYVE	LIG_APCC_ABBA_1	0.2222
p.R349Q	DO227999	COCA	ICGC	FTPYVE	LIG_APCC_ABBA_1	0.2222
p.R349Q	DO229016	COCA	ICGC	FTPYVE	LIG_APCC_ABBA_1	0.2222
p.R349Q	DO234285	ESAD	ICGC	FTPYVE	LIG_APCC_ABBA_1	0.2222
p.R349Q	DO229489	LAML	ICGC	FTPYVE	LIG_APCC_ABBA_1	0.2222
p.R349Q	DO228941	LICA	ICGC	FTPYVE	LIG_APCC_ABBA_1	0.2222
p.A335S	DO229015	LICA	ICGC	FTPYVE	LIG_APCC_ABBA_1	0.1944
p.V336L	DO23452	LINC	ICGC	FTPYVE	LIG_APCC_ABBA_1	0.2222
p.P334L	SIDM00646	Small Cell Lung Carcinoma	GDSC	FTPYVE	LIG_APCC_ABBA_1	0.1667
p.P334L	SIDM00519	Mesothelioma	GDSC	FTPYVE	LIG_APCC_ABBA_1	0.1667
p.P351S	SIDM01175	Other Sarcomas	GDSC	FTPYVE	LIG_APCC_ABBA_1	0.1667
p.P351S	ACH-002309	Sarcoma	CCLE	FTPYVE	LIG_APCC_ABBA_1	0.1667
p.P351S	SW684	soft_tissue	COSMIC	FTPYVE	LIG_APCC_ABBA_1	0.1667
p.A335V	SIDM01618	B-Lymphoblastic Leukemia	GDSC	FTPYVE	LIG_APCC_ABBA_1	0.1944
p.A335V	ACH-000942	Leukemia	CCLE	FTPYVE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	LIG_APCC_ABBA_1	340:345	FTPYVE	APC,CDC20,FZR1	0.9646	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons