DegronMD

Uniprot ID: O60566

Source protein: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Source gene: BUB1B

Class: LIG_APCC_ABBA_1

Location: 272:277

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9795

ASA_SCORE: 60.6

COIL: 0.393

CONS_SCORE: 0.3283

DSS_SCORE: 0.6184

HELIX: 0.0527

FCONS_SCORE: 1.261

RIG_SCORE: 0.7737

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M266I	DO228952	LICA	ICGC	ITVFDE	LIG_APCC_ABBA_1	0.1667
p.N268D	ACH-000911	Gastric Cancer	CCLE	ITVFDE	LIG_APCC_ABBA_1	0.2222
p.I272L	ACH-000993	Endometrial/Uterine Cancer	CCLE	ITVFDE	LIG_APCC_ABBA_1	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	LIG_APCC_ABBA_1	272:277	ITVFDE	APC,CDC20,FZR1	0.9795	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons