DegronMD

Uniprot ID: O60566

Source protein: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Source gene: BUB1B

Class: LIG_APCC_ABBA_1

Location: 528:533

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9907

ASA_SCORE: 73.15

COIL: 0.4845

CONS_SCORE: 0.2618

DSS_SCORE: 0.3796

HELIX: 0.4555

FCONS_SCORE: 0.9858

RIG_SCORE: 0.7949

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S521Y	TCGA-A5-A0G2	UCEC	TCGA	FSIFDE	LIG_APCC_ABBA_1	0.5833
p.S521Y	DO41235	UCEC	ICGC	FSIFDE	LIG_APCC_ABBA_1	0.5833
p.P524L	TCGA-D3-A3CB	SKCM	TCGA	FSIFDE	LIG_APCC_ABBA_1	0.2222
p.P538L	DO47386	SKCM	ICGC	FSIFDE	LIG_APCC_ABBA_1	0.1944
p.F542S	DO229248	THCA	ICGC	FSIFDE	LIG_APCC_ABBA_1	0.5278
p.S521F	SIDM00963	Breast Carcinoma	GDSC	FSIFDE	LIG_APCC_ABBA_1	0.5833
p.S521F	ACH-000927	Breast Cancer	CCLE	FSIFDE	LIG_APCC_ABBA_1	0.5833
p.S521F	BT-474	breast	COSMIC	FSIFDE	LIG_APCC_ABBA_1	0.5833
p.S543I	SIDM00079	Ovarian Carcinoma	GDSC	FSIFDE	LIG_APCC_ABBA_1	0.5
p.S543I	SK-OV-3	ovary	COSMIC	FSIFDE	LIG_APCC_ABBA_1	0.5
p.S535F	BT-474	breast	COSMIC	FSIFDE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	LIG_APCC_ABBA_1	528:533	FSIFDE	APC,CDC20,FZR1	0.9907	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons