DegronMD

Uniprot ID: O60566

Source protein: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Source gene: BUB1B

Class: LIG_APCC_ABBAyCdc20_2

Location: 271:277

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.951

ASA_SCORE: 70.6571

COIL: 0.4331

CONS_SCORE: 0.3194

DSS_SCORE: 0.6225

HELIX: 0.0509

FCONS_SCORE: 1.2228

RIG_SCORE: 0.7671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R271I	TCGA-EO-A22X	UCEC	TCGA	RITVFDE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R271I	DO43907	UCEC	ICGC	RITVFDE	LIG_APCC_ABBAyCdc20_2	0.8102
p.M266I	DO228952	LICA	ICGC	RITVFDE	LIG_APCC_ABBAyCdc20_2	0.1944
p.N268D	ACH-000911	Gastric Cancer	CCLE	RITVFDE	LIG_APCC_ABBAyCdc20_2	0.25
p.I272L	ACH-000993	Endometrial/Uterine Cancer	CCLE	RITVFDE	LIG_APCC_ABBAyCdc20_2	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	LIG_APCC_ABBAyCdc20_2	271:277	RITVFDE	APC,CDC20,FZR1	0.951	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons