DegronMD

Uniprot ID: O60566

Source protein: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Source gene: BUB1B

Class: DEG_APCC_DBOX_1

Location: 223:231

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9989

ASA_SCORE: 82.4556

COIL: 0.3769

CONS_SCORE: 0.4037

DSS_SCORE: 0.4765

HELIX: 0.5932

FCONS_SCORE: 1.4748

RIG_SCORE: 0.739

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S220C	TCGA-CU-A3YL	BLCA	TCGA	QRSTLAELK	DEG_APCC_DBOX_1	0.25
p.S220C	DO834	BLCA	ICGC	QRSTLAELK	DEG_APCC_DBOX_1	0.25
p.P241A	TCGA-D8-A73U	BRCA	TCGA	QRSTLAELK	DEG_APCC_DBOX_1	0.0556
p.P241A	DO219629	BRCA	ICGC	QRSTLAELK	DEG_APCC_DBOX_1	0.0556
p.P222Q	TCGA-ER-A19B	SKCM	TCGA	QRSTLAELK	DEG_APCC_DBOX_1	0.3056
p.P222Q	DO47491	SKCM	ICGC	QRSTLAELK	DEG_APCC_DBOX_1	0.3056
p.P241T	TCGA-FS-A1ZM	SKCM	TCGA	QRSTLAELK	DEG_APCC_DBOX_1	0.0556
p.P241T	DO37731	SKCM	ICGC	QRSTLAELK	DEG_APCC_DBOX_1	0.0556
p.E218Q	DO1076	BRCA	ICGC	QRSTLAELK	DEG_APCC_DBOX_1	0.1944
p.S225I	DO229037	LICA	ICGC	QRSTLAELK	DEG_APCC_DBOX_1	0.623
p.R213P	SNU-182	liver	COSMIC	QRSTLAELK	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	DEG_APCC_DBOX_1	223:231	QRSTLAELK	APC,CDC20,FZR1	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons