DegronMD

Uniprot ID: O60566

Source protein: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Source gene: BUB1B

Class: DEG_SPOP_SBC_1

Location: 692:696

E3 ligase: SPOP

DEGRON score: 0.9993

ASA_SCORE: 78.98

COIL: 0.8664

CONS_SCORE: 0.271

DSS_SCORE: 0.3633

HELIX: 0.089

FCONS_SCORE: 1.0052

RIG_SCORE: 0.6604

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E705D	TCGA-BS-A0UF	UCEC	TCGA	VASTS	DEG_SPOP_SBC_1	0.0833
p.E705K	TCGA-C4-A0F1	BLCA	TCGA	VASTS	DEG_SPOP_SBC_1	0.0833
p.P704S	TCGA-EE-A29E	SKCM	TCGA	VASTS	DEG_SPOP_SBC_1	0.1111
p.S689F	TCGA-W3-A825	SKCM	TCGA	VASTS	DEG_SPOP_SBC_1	0.25
p.L683P	DO44170	BRCA	ICGC	VASTS	DEG_SPOP_SBC_1	0.5278
p.R691H	DO25183	LUAD	ICGC	VASTS	DEG_SPOP_SBC_1	0.3056
p.R691H	SW1783	central_nervous_system	COSMIC	VASTS	DEG_SPOP_SBC_1	0.3056
p.S684R	DO228343	MALY	ICGC	VASTS	DEG_SPOP_SBC_1	0.1111
p.I687S	DO232224	PBCA	ICGC	VASTS	DEG_SPOP_SBC_1	0.1944
p.S703F	DO51272	SKCM	ICGC	VASTS	DEG_SPOP_SBC_1	0.1389
p.S691L	SIDM01018	Hodgkin's Lymphoma	GDSC	VASTS	DEG_SPOP_SBC_1	0.3056
p.S691L	ACH-000815	Lymphoma	CCLE	VASTS	DEG_SPOP_SBC_1	0.3056
p.S691L	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	VASTS	DEG_SPOP_SBC_1	0.3056
p.S684I	IM-95	stomach	COSMIC	VASTS	DEG_SPOP_SBC_1	0.1111
p.I686S	HT-115	large_intestine	COSMIC	VASTS	DEG_SPOP_SBC_1	0.1667
p.S705L	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	VASTS	DEG_SPOP_SBC_1	0.0833
p.H695P	OVKATE	ovary	COSMIC	VASTS	DEG_SPOP_SBC_1	0.7694

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	DEG_SPOP_SBC_1	692:696	VASTS	SPOP	0.9993	More...
P55211	Caspase-9	DEG_SPOP_SBC_1	298:302	VASTS	SPOP	0.9605	More...
Q13485	Mothers against decapentaplegic homolog 4	DEG_SPOP_SBC_1	219:223	VASTS	SPOP	0.8809	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	970:974	VASTS	SPOP	0.9754	More...
Q53GL0	Pleckstrin homology domain-containing family O member 1	DEG_SPOP_SBC_1	175:179	VASTS	SPOP	0.863	More...
Q5VX71	Sushi domain-containing protein 4	DEG_SPOP_SBC_1	470:474	VASTS	SPOP	0.9726	More...
Q8TEV9	Guanine nucleotide exchange protein SMCR8	DEG_SPOP_SBC_1	681:685	VASTS	SPOP	0.9888	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons