DegronMD - Q53GL0(PLEKHO1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A176S	TCGA-14-1458	GBM	TCGA	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.6477
p.A176S	TCGA-14-1458	GBM	TCGA	VASTS	DEG_SPOP_SBC_1	175:179	Mutation altering degron motif	0.6477
p.R164P	TCGA-34-5241	LUSC	TCGA	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.2222
p.R164P	DO27341	LUSC	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.2222
p.L189S	TCGA-AB-2806	LAML	TCGA	VASTS	DEG_SPOP_SBC_1	175:179	Mutation rewiring degron network	0.0556
p.P167T	TCGA-D9-A148	SKCM	TCGA	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.3056
p.P167T	TCGA-D9-A148	SKCM	TCGA	VASTS	DEG_SPOP_SBC_1	175:179	Mutation rewiring degron network	0.1111
p.P167T	DO37971	SKCM	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.3056
p.P167T	DO37971	SKCM	ICGC	VASTS	DEG_SPOP_SBC_1	175:179	Mutation rewiring degron network	0.1111
p.T186A	TCGA-FI-A2D5	UCEC	TCGA	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.0556
p.T186A	TCGA-FI-A2D5	UCEC	TCGA	VASTS	DEG_SPOP_SBC_1	175:179	Mutation rewiring degron network	0.1389
p.A174V	DO229342	BTCA	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.5825
p.A174V	SIDM01088	Endometrial Carcinoma	GDSC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.5825
p.A174V	ACH-000965	Endometrial/Uterine Cancer	CCLE	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.5825
p.A174V	RL95-2	endometrium	COSMIC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.5825
p.R174W	DO44314	CESC	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.8634
p.R174W	DO234219	ESAD	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.8634
p.R174Q	DO227646	COCA	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.7329
p.R174Q	DO222636	ESCA	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.7329
p.S172N	DO48568	LGG	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.7069
p.S187I	DO229029	LICA	ICGC	VASTS	DEG_SPOP_SBC_1	175:179	Mutation rewiring degron network	0.1111
p.S168C	DO22896	LIHC	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.7541
p.S168A	DO52326	LIHC	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.7588
p.E171K	DO24596	LUAD	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.7022
p.D160N	DO45318	LUAD	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.1111
p.E164K	DO29950	OV	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.2222
p.S172R	DO232761	PBCA	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.7427
p.S163F	DO229446	SKCA	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.1944
p.P163T	DO47578	SKCM	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.1944
p.A170V	DO42793	UCEC	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.6936
p.T180S	SIDM01157	Other Solid Cancers	GDSC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.2222
p.T180S	SIDM01157	Other Solid Cancers	GDSC	VASTS	DEG_SPOP_SBC_1	175:179	Mutation rewiring degron network	0.3056
p.T180S	ACH-001400	Cervical Cancer	CCLE	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.2222
p.T180S	ACH-001400	Cervical Cancer	CCLE	VASTS	DEG_SPOP_SBC_1	175:179	Mutation rewiring degron network	0.3056
p.T180S	SW954	vulva	COSMIC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.2222
p.T180S	SW954	vulva	COSMIC	VASTS	DEG_SPOP_SBC_1	175:179	Mutation rewiring degron network	0.3056
p.R164C	SIDM00837	Colorectal Carcinoma	GDSC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.2222
p.R164C	ACH-000958	Colon/Colorectal Cancer	CCLE	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.2222
p.R164C	SW48	large intestine	COSMIC	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation rewiring degron network	0.2222
p.R169M	ACH-001853	Bile Duct Cancer	CCLE	TRGHLMAVA	DEG_APCC_DBOX_1	168:176	Mutation altering degron motif	0.8632
p.V189E	NCI-H128	lung	COSMIC	VASTS	DEG_SPOP_SBC_1	175:179	Mutation rewiring degron network	0.0556

Kaplan plot for PLEKHO1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHO1

UniProt ID: Q53GL0

Entrez ID: 51177

Protein name: Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHO1 in