DegronMD

Uniprot ID: Q53GL0

Source protein: Pleckstrin homology domain-containing family O member 1

Source gene: PLEKHO1

Class: DEG_APCC_DBOX_1

Location: 168:176

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7578

ASA_SCORE: 85.8

COIL: 0.6522

CONS_SCORE: 0.8099

DSS_SCORE: 0.6688

HELIX: 0.2666

FCONS_SCORE: 1.0925

RIG_SCORE: 0.6594

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A176S	TCGA-14-1458	GBM	TCGA	TRGHLMAVA	DEG_APCC_DBOX_1	0.6477
p.R164P	TCGA-34-5241	LUSC	TCGA	TRGHLMAVA	DEG_APCC_DBOX_1	0.2222
p.R164P	DO27341	LUSC	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	0.2222
p.P167T	TCGA-D9-A148	SKCM	TCGA	TRGHLMAVA	DEG_APCC_DBOX_1	0.3056
p.P167T	DO37971	SKCM	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	0.3056
p.T186A	TCGA-FI-A2D5	UCEC	TCGA	TRGHLMAVA	DEG_APCC_DBOX_1	0.0556
p.A174V	DO229342	BTCA	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	0.5825
p.A174V	SIDM01088	Endometrial Carcinoma	GDSC	TRGHLMAVA	DEG_APCC_DBOX_1	0.5825
p.A174V	ACH-000965	Endometrial/Uterine Cancer	CCLE	TRGHLMAVA	DEG_APCC_DBOX_1	0.5825
p.A174V	RL95-2	endometrium	COSMIC	TRGHLMAVA	DEG_APCC_DBOX_1	0.5825
p.R174W	DO44314	CESC	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	0.8634
p.R174W	DO234219	ESAD	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	0.8634
p.R174Q	DO227646	COCA	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	0.7329
p.R174Q	DO222636	ESCA	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	0.7329
p.S172N	DO48568	LGG	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	0.7069
p.S168C	DO22896	LIHC	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	0.7541
p.S168A	DO52326	LIHC	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	0.7588
p.E171K	DO24596	LUAD	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	0.7022
p.D160N	DO45318	LUAD	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	0.1111
p.E164K	DO29950	OV	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	0.2222
p.S172R	DO232761	PBCA	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	0.7427
p.S163F	DO229446	SKCA	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	0.1944
p.P163T	DO47578	SKCM	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	0.1944
p.A170V	DO42793	UCEC	ICGC	TRGHLMAVA	DEG_APCC_DBOX_1	0.6936
p.T180S	SIDM01157	Other Solid Cancers	GDSC	TRGHLMAVA	DEG_APCC_DBOX_1	0.2222
p.T180S	ACH-001400	Cervical Cancer	CCLE	TRGHLMAVA	DEG_APCC_DBOX_1	0.2222
p.T180S	SW954	vulva	COSMIC	TRGHLMAVA	DEG_APCC_DBOX_1	0.2222
p.R164C	SIDM00837	Colorectal Carcinoma	GDSC	TRGHLMAVA	DEG_APCC_DBOX_1	0.2222
p.R164C	ACH-000958	Colon/Colorectal Cancer	CCLE	TRGHLMAVA	DEG_APCC_DBOX_1	0.2222
p.R164C	SW48	large_intestine	COSMIC	TRGHLMAVA	DEG_APCC_DBOX_1	0.2222
p.R169M	ACH-001853	Bile Duct Cancer	CCLE	TRGHLMAVA	DEG_APCC_DBOX_1	0.8632

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRGHLMAVA

Degron related mutations and impact score

Drug responses associated with PLEKHO1 mutations

All proteins holding degron of TRGHLMAVA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53GL0	Pleckstrin homology domain-containing family O member 1	DEG_APCC_DBOX_1	168:176	TRGHLMAVA	APC,CDC20,FZR1	0.7578	More...