DegronMD

Uniprot ID: Q53GL0

Source protein: Pleckstrin homology domain-containing family O member 1

Source gene: PLEKHO1

Class: DEG_SPOP_SBC_1

Location: 175:179

E3 ligase: SPOP

DEGRON score: 0.863

ASA_SCORE: 74.86

COIL: 0.7334

CONS_SCORE: 0.7316

DSS_SCORE: 0.5913

HELIX: 0.1438

FCONS_SCORE: 0.9517

RIG_SCORE: 0.6586

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A176S	TCGA-14-1458	GBM	TCGA	VASTS	DEG_SPOP_SBC_1	0.6477
p.L189S	TCGA-AB-2806	LAML	TCGA	VASTS	DEG_SPOP_SBC_1	0.0556
p.P167T	TCGA-D9-A148	SKCM	TCGA	VASTS	DEG_SPOP_SBC_1	0.1111
p.P167T	DO37971	SKCM	ICGC	VASTS	DEG_SPOP_SBC_1	0.1111
p.T186A	TCGA-FI-A2D5	UCEC	TCGA	VASTS	DEG_SPOP_SBC_1	0.1389
p.S187I	DO229029	LICA	ICGC	VASTS	DEG_SPOP_SBC_1	0.1111
p.T180S	SIDM01157	Other Solid Cancers	GDSC	VASTS	DEG_SPOP_SBC_1	0.3056
p.T180S	ACH-001400	Cervical Cancer	CCLE	VASTS	DEG_SPOP_SBC_1	0.3056
p.T180S	SW954	vulva	COSMIC	VASTS	DEG_SPOP_SBC_1	0.3056
p.V189E	NCI-H128	lung	COSMIC	VASTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	DEG_SPOP_SBC_1	692:696	VASTS	SPOP	0.9993	More...
P55211	Caspase-9	DEG_SPOP_SBC_1	298:302	VASTS	SPOP	0.9605	More...
Q13485	Mothers against decapentaplegic homolog 4	DEG_SPOP_SBC_1	219:223	VASTS	SPOP	0.8809	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	970:974	VASTS	SPOP	0.9754	More...
Q53GL0	Pleckstrin homology domain-containing family O member 1	DEG_SPOP_SBC_1	175:179	VASTS	SPOP	0.863	More...
Q5VX71	Sushi domain-containing protein 4	DEG_SPOP_SBC_1	470:474	VASTS	SPOP	0.9726	More...
Q8TEV9	Guanine nucleotide exchange protein SMCR8	DEG_SPOP_SBC_1	681:685	VASTS	SPOP	0.9888	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons