DegronMD

Uniprot ID: P55211

Source protein: Caspase-9

Source gene: CASP9

Class: DEG_SPOP_SBC_1

Location: 298:302

E3 ligase: SPOP

DEGRON score: 0.9605

ASA_SCORE: 56.18

COIL: 0.786

CONS_SCORE: 0.3276

DSS_SCORE: 0.7993

HELIX: 0.023

FCONS_SCORE: 0.609

RIG_SCORE: 0.629

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S307F	TCGA-EE-A2A2	SKCM	TCGA	VASTS	DEG_SPOP_SBC_1	0.6389
p.S307F	DO37583	SKCM	ICGC	VASTS	DEG_SPOP_SBC_1	0.6389
p.S302F	DO222363	MELA	ICGC	VASTS	DEG_SPOP_SBC_1	0.9093
p.E306K	SIDM00874	Breast Carcinoma	GDSC	VASTS	DEG_SPOP_SBC_1	0.2222
p.E306K	ACH-000223	Breast Cancer	CCLE	VASTS	DEG_SPOP_SBC_1	0.2222
p.E306K	HCC1937	breast	COSMIC	VASTS	DEG_SPOP_SBC_1	0.2222
p.S310I	ACH-000945	Lung Cancer	CCLE	VASTS	DEG_SPOP_SBC_1	0.5556
p.H293Y	G-MEL	skin	COSMIC	VASTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	DEG_SPOP_SBC_1	692:696	VASTS	SPOP	0.9993	More...
P55211	Caspase-9	DEG_SPOP_SBC_1	298:302	VASTS	SPOP	0.9605	More...
Q13485	Mothers against decapentaplegic homolog 4	DEG_SPOP_SBC_1	219:223	VASTS	SPOP	0.8809	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	970:974	VASTS	SPOP	0.9754	More...
Q53GL0	Pleckstrin homology domain-containing family O member 1	DEG_SPOP_SBC_1	175:179	VASTS	SPOP	0.863	More...
Q5VX71	Sushi domain-containing protein 4	DEG_SPOP_SBC_1	470:474	VASTS	SPOP	0.9726	More...
Q8TEV9	Guanine nucleotide exchange protein SMCR8	DEG_SPOP_SBC_1	681:685	VASTS	SPOP	0.9888	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons