DegronMD

Uniprot ID: Q8TEV9

Source protein: Guanine nucleotide exchange protein SMCR8

Source gene: SMCR8

Class: DEG_SPOP_SBC_1

Location: 681:685

E3 ligase: SPOP

DEGRON score: 0.9888

ASA_SCORE: 73.6

COIL: 0.8872

CONS_SCORE: 0.4218

DSS_SCORE: 0.4177

HELIX: 0.068

FCONS_SCORE: 1.0608

RIG_SCORE: 0.673

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A682T	TCGA-IB-7651	PAAD	TCGA	VASTS	DEG_SPOP_SBC_1	0.6028
p.A682T	DO46657	PAAD	ICGC	VASTS	DEG_SPOP_SBC_1	0.6028
p.I689M	DO230334	COCA	ICGC	VASTS	DEG_SPOP_SBC_1	0.2222
p.P690S	DO38404	STAD	ICGC	VASTS	DEG_SPOP_SBC_1	0.1944
p.S686T	SIDM00586	Hepatocellular Carcinoma	GDSC	VASTS	DEG_SPOP_SBC_1	0.3056
p.S686T	ACH-000475	Liver Cancer	CCLE	VASTS	DEG_SPOP_SBC_1	0.3056
p.S686T	huH-1	liver	COSMIC	VASTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	DEG_SPOP_SBC_1	692:696	VASTS	SPOP	0.9993	More...
P55211	Caspase-9	DEG_SPOP_SBC_1	298:302	VASTS	SPOP	0.9605	More...
Q13485	Mothers against decapentaplegic homolog 4	DEG_SPOP_SBC_1	219:223	VASTS	SPOP	0.8809	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	970:974	VASTS	SPOP	0.9754	More...
Q53GL0	Pleckstrin homology domain-containing family O member 1	DEG_SPOP_SBC_1	175:179	VASTS	SPOP	0.863	More...
Q5VX71	Sushi domain-containing protein 4	DEG_SPOP_SBC_1	470:474	VASTS	SPOP	0.9726	More...
Q8TEV9	Guanine nucleotide exchange protein SMCR8	DEG_SPOP_SBC_1	681:685	VASTS	SPOP	0.9888	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons