DegronMD - Q13485(SMAD4)

GO - Biological processes (BP): adrenal gland development [GO:0030325]; aging [GO:0007568]; anatomical structure morphogenesis [GO:0009653]; atrioventricular canal development [GO:0036302]; atrioventricular valve formation [GO:0003190]; axon guidance [GO:0007411]; BMP signaling pathway [GO:0030509]; brainstem development [GO:0003360]; branching involved in ureteric bud morphogenesis [GO:0001658]; cardiac conduction system development [GO:0003161]; cell differentiation [GO:0030154]; cell population proliferation [GO:0008283]; cellular iron ion homeostasis [GO:0006879]; cellular response to BMP stimulus [GO:0071773]; cellular response to glucose stimulus [GO:0071333]; developmental growth [GO:0048589]; embryonic digit morphogenesis [GO:0042733]; endocardial cell differentiation [GO:0060956]; endothelial cell activation [GO:0042118]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; ERK1 and ERK2 cascade [GO:0070371]; female gonad morphogenesis [GO:0061040]; formation of anatomical boundary [GO:0048859]; gastrulation with mouth forming second [GO:0001702]; interleukin-6-mediated signaling pathway [GO:0070102]; intracellular signal transduction [GO:0035556]; in utero embryonic development [GO:0001701]; left ventricular cardiac muscle tissue morphogenesis [GO:0003220]; mesendoderm development [GO:0048382]; metanephric mesenchyme morphogenesis [GO:0072133]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cardiac myofibril assembly [GO:1905305]; negative regulation of cell death [GO:0060548]; negative regulation of cell growth [GO:0030308]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nephrogenic mesenchyme morphogenesis [GO:0072134]; neural crest cell differentiation [GO:0014033]; neuron fate commitment [GO:0048663]; osteoblast differentiation [GO:0001649]; outflow tract septum morphogenesis [GO:0003148]; ovarian follicle development [GO:0001541]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cell proliferation involved in heart valve morphogenesis [GO:0003251]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of follicle-stimulating hormone secretion [GO:0046881]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of histone H3-K9 acetylation [GO:2000617]; positive regulation of luteinizing hormone secretion [GO:0033686]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [GO:1901522]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; regulation of binding [GO:0051098]; regulation of hair follicle development [GO:0051797]; regulation of transforming growth factor beta2 production [GO:0032909]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]; response to hypoxia [GO:0001666]; response to transforming growth factor beta [GO:0071559]; sebaceous gland development [GO:0048733]; secondary palate development [GO:0062009]; seminiferous tubule development [GO:0072520]; single fertilization [GO:0007338]; SMAD protein complex assembly [GO:0007183]; SMAD protein signal transduction [GO:0060395]; somite rostral/caudal axis specification [GO:0032525]; spermatogenesis [GO:0007283]; transcription, DNA-templated [GO:0006351]; transforming growth factor beta receptor signaling pathway [GO:0007179]; uterus development [GO:0060065]; ventricular septum morphogenesis [GO:0060412]; wound healing [GO:0042060] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P215S	TCGA-86-7713	LUAD	TCGA	VASTS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.2222
p.P215S	DO24712	LUAD	ICGC	VASTS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.2222
p.N216T	DO8730	COAD	ICGC	VASTS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.25
p.V219L	DO46358	OV	ICGC	VASTS	DEG_SPOP_SBC_1	219:223	Mutation altering degron motif	0.6765
p.S232N	SIDM00216	Colorectal Carcinoma	GDSC	VASTS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.0833
p.S232N	ACH-000989	Colon/Colorectal Cancer	CCLE	VASTS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.0833
p.S232N	SNU-175	large intestine	COSMIC	VASTS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.0833
p.S210N	ACH-000928	Endometrial/Uterine Cancer	CCLE	VASTS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.0833
p.P218S	ACH-000928	Endometrial/Uterine Cancer	CCLE	VASTS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.3056
p.Y226H	ACH-000990	Endometrial/Uterine Cancer	CCLE	VASTS	DEG_SPOP_SBC_1	219:223	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMAD4

UniProt ID: Q13485

Entrez ID: 4089

Protein name: Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMAD4 in