DegronMD

Uniprot ID: Q13485

Source protein: Mothers against decapentaplegic homolog 4

Source gene: SMAD4

Class: DEG_SPOP_SBC_1

Location: 219:223

E3 ligase: SPOP

DEGRON score: 0.8809

ASA_SCORE: 63.62

COIL: 0.8716

CONS_SCORE: 0.3504

DSS_SCORE: 0.4801

HELIX: 0.0634

FCONS_SCORE: 0.9526

RIG_SCORE: 0.7002

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P215S	TCGA-86-7713	LUAD	TCGA	VASTS	DEG_SPOP_SBC_1	0.2222
p.P215S	DO24712	LUAD	ICGC	VASTS	DEG_SPOP_SBC_1	0.2222
p.N216T	DO8730	COAD	ICGC	VASTS	DEG_SPOP_SBC_1	0.25
p.V219L	DO46358	OV	ICGC	VASTS	DEG_SPOP_SBC_1	0.6765
p.S232N	SIDM00216	Colorectal Carcinoma	GDSC	VASTS	DEG_SPOP_SBC_1	0.0833
p.S232N	ACH-000989	Colon/Colorectal Cancer	CCLE	VASTS	DEG_SPOP_SBC_1	0.0833
p.S232N	SNU-175	large_intestine	COSMIC	VASTS	DEG_SPOP_SBC_1	0.0833
p.S210N	ACH-000928	Endometrial/Uterine Cancer	CCLE	VASTS	DEG_SPOP_SBC_1	0.0833
p.P218S	ACH-000928	Endometrial/Uterine Cancer	CCLE	VASTS	DEG_SPOP_SBC_1	0.3056
p.Y226H	ACH-000990	Endometrial/Uterine Cancer	CCLE	VASTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	DEG_SPOP_SBC_1	692:696	VASTS	SPOP	0.9993	More...
P55211	Caspase-9	DEG_SPOP_SBC_1	298:302	VASTS	SPOP	0.9605	More...
Q13485	Mothers against decapentaplegic homolog 4	DEG_SPOP_SBC_1	219:223	VASTS	SPOP	0.8809	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	970:974	VASTS	SPOP	0.9754	More...
Q53GL0	Pleckstrin homology domain-containing family O member 1	DEG_SPOP_SBC_1	175:179	VASTS	SPOP	0.863	More...
Q5VX71	Sushi domain-containing protein 4	DEG_SPOP_SBC_1	470:474	VASTS	SPOP	0.9726	More...
Q8TEV9	Guanine nucleotide exchange protein SMCR8	DEG_SPOP_SBC_1	681:685	VASTS	SPOP	0.9888	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons