DegronMD

Uniprot ID: Q5VX71

Source protein: Sushi domain-containing protein 4

Source gene: SUSD4

Class: DEG_SPOP_SBC_1

Location: 470:474

E3 ligase: SPOP

DEGRON score: 0.9726

ASA_SCORE: 54.18

COIL: 0.7284

CONS_SCORE: 0.9235

DSS_SCORE: 0.6056

HELIX: 0.1674

FCONS_SCORE: 1.152

RIG_SCORE: 0.6701

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G476D	TCGA-17-Z042	LUAD	TCGA	VASTS	DEG_SPOP_SBC_1	0.2778
p.P484T	TCGA-AA-A010	COAD	TCGA	VASTS	DEG_SPOP_SBC_1	0.0556
p.T466M	TCGA-AX-A2HG	UCEC	TCGA	VASTS	DEG_SPOP_SBC_1	0.2222
p.T466M	SIDM00238	Ovarian Carcinoma	GDSC	VASTS	DEG_SPOP_SBC_1	0.2222
p.T466M	OVK-18	ovary	COSMIC	VASTS	DEG_SPOP_SBC_1	0.2222
p.E468K	TCGA-D3-A8GM	SKCM	TCGA	VASTS	DEG_SPOP_SBC_1	0.2778
p.E469K	TCGA-ER-A194	SKCM	TCGA	VASTS	DEG_SPOP_SBC_1	0.3056
p.S472F	TCGA-HF-7132	STAD	TCGA	VASTS	DEG_SPOP_SBC_1	0.7982
p.A464S	SIDM00672	Hepatocellular Carcinoma	GDSC	VASTS	DEG_SPOP_SBC_1	0.1667
p.A464S	SIDM01126	Small Cell Lung Carcinoma	GDSC	VASTS	DEG_SPOP_SBC_1	0.1667
p.A464S	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	VASTS	DEG_SPOP_SBC_1	0.1667
p.A464S	SIDM00285	Neuroblastoma	GDSC	VASTS	DEG_SPOP_SBC_1	0.1667
p.A464S	SIDM00976	Melanoma	GDSC	VASTS	DEG_SPOP_SBC_1	0.1667
p.A471P	SIDM01140	Ovarian Carcinoma	GDSC	VASTS	DEG_SPOP_SBC_1	0.6392

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	DEG_SPOP_SBC_1	692:696	VASTS	SPOP	0.9993	More...
P55211	Caspase-9	DEG_SPOP_SBC_1	298:302	VASTS	SPOP	0.9605	More...
Q13485	Mothers against decapentaplegic homolog 4	DEG_SPOP_SBC_1	219:223	VASTS	SPOP	0.8809	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	970:974	VASTS	SPOP	0.9754	More...
Q53GL0	Pleckstrin homology domain-containing family O member 1	DEG_SPOP_SBC_1	175:179	VASTS	SPOP	0.863	More...
Q5VX71	Sushi domain-containing protein 4	DEG_SPOP_SBC_1	470:474	VASTS	SPOP	0.9726	More...
Q8TEV9	Guanine nucleotide exchange protein SMCR8	DEG_SPOP_SBC_1	681:685	VASTS	SPOP	0.9888	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons