DegronMD - Q5VX71(SUSD4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q409H	TCGA-05-4250	LUAD	TCGA	PPAY	ITCH	411:414	Mutation rewiring degron network	0.2778
p.Q409H	TCGA-DR-A0ZM	CESC	TCGA	PPAY	ITCH	411:414	Mutation rewiring degron network	0.2778
p.G476D	TCGA-17-Z042	LUAD	TCGA	VASTS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.2778
p.G423C	TCGA-A5-A0G2	UCEC	TCGA	PPAY	ITCH	411:414	Mutation rewiring degron network	0.0833
p.P484T	TCGA-AA-A010	COAD	TCGA	VASTS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.0556
p.V406M	TCGA-AX-A05Y	UCEC	TCGA	PPAY	ITCH	411:414	Mutation rewiring degron network	0.1944
p.V406M	TCGA-AX-A3G8	UCEC	TCGA	PPAY	ITCH	411:414	Mutation rewiring degron network	0.1944
p.V406M	SIDM01037	Breast Carcinoma	GDSC	PPAY	ITCH	411:414	Mutation rewiring degron network	0.1944
p.V406M	ACH-000711	Breast Cancer	CCLE	PPAY	ITCH	411:414	Mutation rewiring degron network	0.1944
p.T466M	TCGA-AX-A2HG	UCEC	TCGA	VASTS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.2222
p.T466M	SIDM00238	Ovarian Carcinoma	GDSC	VASTS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.2222
p.T466M	OVK-18	ovary	COSMIC	VASTS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.2222
p.E468K	TCGA-D3-A8GM	SKCM	TCGA	VASTS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.2778
p.S417L	TCGA-D3-A8GO	SKCM	TCGA	PPAY	ITCH	411:414	Mutation rewiring degron network	0.25
p.E469K	TCGA-ER-A194	SKCM	TCGA	VASTS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.3056
p.S472F	TCGA-HF-7132	STAD	TCGA	VASTS	DEG_SPOP_SBC_1	470:474	Mutation altering degron motif	0.7982
p.D407N	TCGA-RP-A694	SKCM	TCGA	PPAY	ITCH	411:414	Mutation rewiring degron network	0.2222
p.D407N	DO231047	LUSC	ICGC	PPAY	ITCH	411:414	Mutation rewiring degron network	0.2222
p.D407N	DO51269	SKCM	ICGC	PPAY	ITCH	411:414	Mutation rewiring degron network	0.2222
p.D420H	DO225028	BRCA	ICGC	PPAY	ITCH	411:414	Mutation rewiring degron network	0.1667
p.P405T	DO229038	LICA	ICGC	PPAY	ITCH	411:414	Mutation rewiring degron network	0.1667
p.A413T	SIDM00396	Acute Myeloid Leukemia	GDSC	PPAY	ITCH	411:414	Mutation altering degron motif	0.6028
p.A413T	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPAY	ITCH	411:414	Mutation altering degron motif	0.6028
p.A464S	SIDM00672	Hepatocellular Carcinoma	GDSC	VASTS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.1667
p.A464S	SIDM01126	Small Cell Lung Carcinoma	GDSC	VASTS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.1667
p.A464S	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	VASTS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.1667
p.A464S	SIDM00285	Neuroblastoma	GDSC	VASTS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.1667
p.A464S	SIDM00976	Melanoma	GDSC	VASTS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.1667
p.A471P	SIDM01140	Ovarian Carcinoma	GDSC	VASTS	DEG_SPOP_SBC_1	470:474	Mutation altering degron motif	0.6392
p.E419K	8-MG-BA	central nervous system	COSMIC	PPAY	ITCH	411:414	Mutation rewiring degron network	0.1944

Kaplan plot for SUSD4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SUSD4

UniProt ID: Q5VX71

Entrez ID: 55061

Protein name: Sushi domain-containing protein 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SUSD4 in