DegronMD - Q8TEV9(SMCR8)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A278T	TCGA-27-1832	GBM	TCGA	ASTTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.25
p.A278T	DO10912	GBM	ICGC	ASTTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.25
p.D459N	TCGA-A5-A0G2	UCEC	TCGA	SISSGE	DEG_Kelch_Keap1_1	465:470	Mutation rewiring degron network	0.1667
p.D459N	DO41235	UCEC	ICGC	SISSGE	DEG_Kelch_Keap1_1	465:470	Mutation rewiring degron network	0.1667
p.E608K	TCGA-A5-A2K5	UCEC	TCGA	LPSTPAHT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.2222
p.E608K	DO41379	UCEC	ICGC	LPSTPAHT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.2222
p.Q277E	TCGA-AX-A2H8	UCEC	TCGA	ASTTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.2222
p.Q277E	DO43674	UCEC	ICGC	ASTTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.2222
p.A309T	TCGA-DF-A2KU	UCEC	TCGA	DTDLYTCRP	CBL_PTK	292:300	Mutation rewiring degron network	0.0833
p.A309T	DO223286	UCEC	ICGC	DTDLYTCRP	CBL_PTK	292:300	Mutation rewiring degron network	0.0833
p.A602T	TCGA-EO-A22T	UCEC	TCGA	LPSTPAHT	DEG_SCF_FBW7_1	597:604	Mutation altering degron motif	0.6028
p.A602T	DO42320	UCEC	ICGC	LPSTPAHT	DEG_SCF_FBW7_1	597:604	Mutation altering degron motif	0.6028
p.E478D	TCGA-F5-6814	READ	TCGA	SISSGE	DEG_Kelch_Keap1_1	465:470	Mutation rewiring degron network	0.1111
p.E478D	DO36556	READ	ICGC	SISSGE	DEG_Kelch_Keap1_1	465:470	Mutation rewiring degron network	0.1111
p.S290F	TCGA-FR-A7UA	SKCM	TCGA	ASTTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1944
p.S290F	TCGA-FR-A7UA	SKCM	TCGA	DTDLYTCRP	CBL_PTK	292:300	Mutation rewiring degron network	0.2778
p.S290F	DO51253	SKCM	ICGC	ASTTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1944
p.S290F	DO51253	SKCM	ICGC	DTDLYTCRP	CBL_PTK	292:300	Mutation rewiring degron network	0.2778
p.A682T	TCGA-IB-7651	PAAD	TCGA	VASTS	DEG_SPOP_SBC_1	681:685	Mutation altering degron motif	0.6028
p.A682T	DO46657	PAAD	ICGC	VASTS	DEG_SPOP_SBC_1	681:685	Mutation altering degron motif	0.6028
p.S591R	TCGA-QK-AA3J	HNSC	TCGA	LPSTPAHT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.1667
p.S591R	DO52101	HNSC	ICGC	LPSTPAHT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.1667
p.T477M	TCGA-SX-A7SN	KIRP	TCGA	SISSGE	DEG_Kelch_Keap1_1	465:470	Mutation rewiring degron network	0.1389
p.T477M	DO49786	KIRP	ICGC	SISSGE	DEG_Kelch_Keap1_1	465:470	Mutation rewiring degron network	0.1389
p.D292N	TCGA-SX-A7SP	KIRP	TCGA	DTDLYTCRP	CBL_PTK	292:300	Mutation altering degron motif	0.5821
p.D292N	DO49790	KIRP	ICGC	DTDLYTCRP	CBL_PTK	292:300	Mutation altering degron motif	0.5821
p.P598L	TCGA-XF-AAN2	BLCA	TCGA	LPSTPAHT	DEG_SCF_FBW7_1	597:604	Mutation altering degron motif	0.6471
p.P598L	DO219052	BLCA	ICGC	LPSTPAHT	DEG_SCF_FBW7_1	597:604	Mutation altering degron motif	0.6471
p.Y302H	DO230309	COCA	ICGC	DTDLYTCRP	CBL_PTK	292:300	Mutation blocking phosphorylation signal	0.7222
p.I689M	DO230334	COCA	ICGC	VASTS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.2222
p.G469C	DO228978	LICA	ICGC	SISSGE	DEG_Kelch_Keap1_1	465:470	Mutation altering degron motif	0.76
p.D609Y	DO229031	LICA	ICGC	LPSTPAHT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.1944
p.L475F	DO229041	LICA	ICGC	SISSGE	DEG_Kelch_Keap1_1	465:470	Mutation rewiring degron network	0.1944
p.E470K	DO229054	LICA	ICGC	SISSGE	DEG_Kelch_Keap1_1	465:470	Mutation altering degron motif	0.7022
p.E608D	DO229008	LICA	ICGC	LPSTPAHT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.2222
p.I466F	DO228162	PBCA	ICGC	SISSGE	DEG_Kelch_Keap1_1	465:470	Mutation altering degron motif	0.6304
p.P690S	DO38404	STAD	ICGC	VASTS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.1944
p.S686T	SIDM00586	Hepatocellular Carcinoma	GDSC	VASTS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.3056
p.S686T	ACH-000475	Liver Cancer	CCLE	VASTS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.3056
p.S686T	huH-1	liver	COSMIC	VASTS	DEG_SPOP_SBC_1	681:685	Mutation rewiring degron network	0.3056
p.M462V	SIDM00422	Hodgkin's Lymphoma	GDSC	SISSGE	DEG_Kelch_Keap1_1	465:470	Mutation rewiring degron network	0.25
p.M462V	ACH-001203	Lymphoma	CCLE	SISSGE	DEG_Kelch_Keap1_1	465:470	Mutation rewiring degron network	0.25
p.M462V	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	SISSGE	DEG_Kelch_Keap1_1	465:470	Mutation rewiring degron network	0.25
p.D461G	SIDM00600	Thyroid Gland Carcinoma	GDSC	SISSGE	DEG_Kelch_Keap1_1	465:470	Mutation rewiring degron network	0.2222
p.D461G	ACH-001528	Thyroid Cancer	CCLE	SISSGE	DEG_Kelch_Keap1_1	465:470	Mutation rewiring degron network	0.2222
p.D461G	IHH-4	thyroid	COSMIC	SISSGE	DEG_Kelch_Keap1_1	465:470	Mutation rewiring degron network	0.2222
p.S468G	SIDM00333	Endometrial Carcinoma	GDSC	SISSGE	DEG_Kelch_Keap1_1	465:470	Mutation altering degron motif	0.8104
p.S468G	ACH-000988	Endometrial/Uterine Cancer	CCLE	SISSGE	DEG_Kelch_Keap1_1	465:470	Mutation altering degron motif	0.8104
p.S468G	MFE-319	endometrium	COSMIC	SISSGE	DEG_Kelch_Keap1_1	465:470	Mutation altering degron motif	0.8104
p.G593C	SIDM00720	Mesothelioma	GDSC	LPSTPAHT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.2222
p.G593C	SIDM01686	Chronic Myelogenous Leukemia	GDSC	LPSTPAHT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.2222
p.G593C	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LPSTPAHT	DEG_SCF_FBW7_1	597:604	Mutation rewiring degron network	0.2222
p.Q280P	SIDM01611	Endometrial Carcinoma	GDSC	ASTTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.3056
p.Q280P	ACH-000996	Endometrial/Uterine Cancer	CCLE	ASTTS	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.3056
p.T297A	ACH-001656	Leukemia	CCLE	DTDLYTCRP	CBL_PTK	292:300	Mutation altering degron motif	0.7139
p.S614R	NCI-H1944	lung	COSMIC	LPSTPAHT	DEG_SCF_FBW7_1	597:604	Mutation blocking phosphorylation signal	0.5

Kaplan plot for SMCR8 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMCR8

UniProt ID: Q8TEV9

Entrez ID: 140775

Protein name: Guanine nucleotide exchange protein SMCR8 (Smith-Magenis syndrome chromosomal region candidate gene 8 protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SMCR8 in