DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DTDLYTCRP
Uniprot ID:
Q8TEV9
Source protein:
Guanine nucleotide exchange protein SMCR8
Source gene:
SMCR8
Class:
CBL_PTK
Location:
292:300
E3 ligase:
CBL
DEGRON score:
0.9875
ASA_SCORE:
81.7333
COIL:
0.8172
CONS_SCORE:
0.4452
DSS_SCORE:
0.4312
HELIX:
0.1239
FCONS_SCORE:
0.8641
RIG_SCORE:
0.7889
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A309T
TCGA-DF-A2KU
UCEC
TCGA
DTDLYTCRP
CBL_PTK
0.0833
p.A309T
DO223286
UCEC
ICGC
DTDLYTCRP
CBL_PTK
0.0833
p.S290F
TCGA-FR-A7UA
SKCM
TCGA
DTDLYTCRP
CBL_PTK
0.2778
p.S290F
DO51253
SKCM
ICGC
DTDLYTCRP
CBL_PTK
0.2778
p.D292N
TCGA-SX-A7SP
KIRP
TCGA
DTDLYTCRP
CBL_PTK
0.5821
p.D292N
DO49790
KIRP
ICGC
DTDLYTCRP
CBL_PTK
0.5821
p.Y302H
DO230309
COCA
ICGC
DTDLYTCRP
CBL_PTK
0.7222
p.T297A
ACH-001656
Leukemia
CCLE
DTDLYTCRP
CBL_PTK
0.7139
Drug responses associated with SMCR8 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DTDLYTCRP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8TEV9
Guanine nucleotide exchange protein SMCR8
CBL_PTK
292:300
DTDLYTCRP
CBL
0.9875
More...
