DegronMD

Uniprot ID: Q8TEV9

Source protein: Guanine nucleotide exchange protein SMCR8

Source gene: SMCR8

Class: DEG_SPOP_SBC_1

Location: 281:285

E3 ligase: SPOP

DEGRON score: 0.6442

ASA_SCORE: 77.32

COIL: 0.8778

CONS_SCORE: 0.4034

DSS_SCORE: 0.6925

HELIX: 0.1004

FCONS_SCORE: 0.9716

RIG_SCORE: 0.5829

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A278T	TCGA-27-1832	GBM	TCGA	ASTTS	DEG_SPOP_SBC_1	0.25
p.A278T	DO10912	GBM	ICGC	ASTTS	DEG_SPOP_SBC_1	0.25
p.Q277E	TCGA-AX-A2H8	UCEC	TCGA	ASTTS	DEG_SPOP_SBC_1	0.2222
p.Q277E	DO43674	UCEC	ICGC	ASTTS	DEG_SPOP_SBC_1	0.2222
p.S290F	TCGA-FR-A7UA	SKCM	TCGA	ASTTS	DEG_SPOP_SBC_1	0.1944
p.S290F	DO51253	SKCM	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1944
p.Q280P	SIDM01611	Endometrial Carcinoma	GDSC	ASTTS	DEG_SPOP_SBC_1	0.3056
p.Q280P	ACH-000996	Endometrial/Uterine Cancer	CCLE	ASTTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SPOP_SBC_1	330:334	ASTTS	SPOP	0.9671	More...
O75037	Kinesin-like protein KIF21B	DEG_SPOP_SBC_1	852:856	ASTTS	SPOP	0.5162	More...
P30518	Vasopressin V2 receptor	DEG_SPOP_SBC_1	4:8	ASTTS	SPOP	0.9728	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2519:2523	ASTTS	SPOP	0.9843	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2642:2646	ASTTS	SPOP	0.8965	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2647:2651	ASTTS	SPOP	0.9326	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2679:2683	ASTTS	SPOP	0.8855	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2687:2691	ASTTS	SPOP	0.9172	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2759:2763	ASTTS	SPOP	0.9813	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2967:2971	ASTTS	SPOP	0.5274	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3055:3059	ASTTS	SPOP	0.8813	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3175:3179	ASTTS	SPOP	0.9626	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3758:3762	ASTTS	SPOP	0.9504	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4236:4240	ASTTS	SPOP	0.9789	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4367:4371	ASTTS	SPOP	0.9931	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4399:4403	ASTTS	SPOP	0.8322	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4431:4435	ASTTS	SPOP	0.6177	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4452:4456	ASTTS	SPOP	0.6169	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4503:4507	ASTTS	SPOP	0.9989	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4535:4539	ASTTS	SPOP	0.996	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	221:225	ASTTS	SPOP	0.9444	More...
Q08AD1	Calmodulin-regulated spectrin-associated protein 2	DEG_SPOP_SBC_1	1335:1339	ASTTS	SPOP	0.981	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	1555:1559	ASTTS	SPOP	0.9902	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	410:414	ASTTS	SPOP	0.9908	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	587:591	ASTTS	SPOP	0.9617	More...
Q8N1G2	Cap-specific mRNA	DEG_SPOP_SBC_1	45:49	ASTTS	SPOP	0.9982	More...
Q8TEV9	Guanine nucleotide exchange protein SMCR8	DEG_SPOP_SBC_1	281:285	ASTTS	SPOP	0.6442	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	616:620	ASTTS	SPOP	0.9558	More...
Q504T8	Midnolin	DEG_SPOP_SBC_1	248:252	ASTTS	SPOP	0.9838	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	878:882	ASTTS	SPOP	0.8808	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1017:1021	ASTTS	SPOP	0.5093	More...
Q96MY1	Nucleolar protein 4-like	DEG_SPOP_SBC_1	374:378	ASTTS	SPOP	0.9269	More...
Q49AM3	Tetratricopeptide repeat protein 31	DEG_SPOP_SBC_1	202:206	ASTTS	SPOP	0.7121	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASTTS

Degron related mutations and impact score

Drug responses associated with SMCR8 mutations

All proteins holding degron of ASTTS