DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 587:591

E3 ligase: SPOP

DEGRON score: 0.9617

ASA_SCORE: 82

COIL: 0.8318

CONS_SCORE: 0.5236

DSS_SCORE: 0.5493

HELIX: 0.0148

FCONS_SCORE: 1

RIG_SCORE: 0.6468

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A595T	TCGA-DA-A95V	SKCM	TCGA	ASTTS	DEG_SPOP_SBC_1	0.2222
p.A595T	DO219478	SKCM	ICGC	ASTTS	DEG_SPOP_SBC_1	0.2222
p.V582M	TCGA-ED-A7PZ	LIHC	TCGA	ASTTS	DEG_SPOP_SBC_1	0.1944
p.V582M	DO48532	LIHC	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1944
p.T599N	TCGA-EY-A1G8	UCEC	TCGA	ASTTS	DEG_SPOP_SBC_1	0.1111
p.T599N	DO43578	UCEC	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1111
p.E586D	TCGA-FD-A43P	BLCA	TCGA	ASTTS	DEG_SPOP_SBC_1	0.3056
p.E586D	DO44049	BLCA	ICGC	ASTTS	DEG_SPOP_SBC_1	0.3056
p.E586D	DO229018	LICA	ICGC	ASTTS	DEG_SPOP_SBC_1	0.3056
p.N598K	TCGA-L5-A8NN	ESCA	TCGA	ASTTS	DEG_SPOP_SBC_1	0.1389
p.L581P	TCGA-PL-A8LV	BRCA	TCGA	ASTTS	DEG_SPOP_SBC_1	0.1667
p.L581P	DO51215	BRCA	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1667
p.E586Q	TCGA-XF-A9T8	BLCA	TCGA	ASTTS	DEG_SPOP_SBC_1	0.3056
p.E586Q	DO51927	BLCA	ICGC	ASTTS	DEG_SPOP_SBC_1	0.3056
p.T589P	DO229016	COCA	ICGC	ASTTS	DEG_SPOP_SBC_1	0.7031
p.R580G	DO234230	ESAD	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1389
p.D596Y	DO23396	LINC	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1944
p.A587T	DO222837	MELA	ICGC	ASTTS	DEG_SPOP_SBC_1	0.7139
p.T590S	SIDM00403	T-Lymphoblastic Leukemia	GDSC	ASTTS	DEG_SPOP_SBC_1	0.6005
p.T590S	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	ASTTS	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SPOP_SBC_1	330:334	ASTTS	SPOP	0.9671	More...
O75037	Kinesin-like protein KIF21B	DEG_SPOP_SBC_1	852:856	ASTTS	SPOP	0.5162	More...
P30518	Vasopressin V2 receptor	DEG_SPOP_SBC_1	4:8	ASTTS	SPOP	0.9728	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2519:2523	ASTTS	SPOP	0.9843	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2642:2646	ASTTS	SPOP	0.8965	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2647:2651	ASTTS	SPOP	0.9326	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2679:2683	ASTTS	SPOP	0.8855	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2687:2691	ASTTS	SPOP	0.9172	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2759:2763	ASTTS	SPOP	0.9813	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2967:2971	ASTTS	SPOP	0.5274	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3055:3059	ASTTS	SPOP	0.8813	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3175:3179	ASTTS	SPOP	0.9626	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3758:3762	ASTTS	SPOP	0.9504	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4236:4240	ASTTS	SPOP	0.9789	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4367:4371	ASTTS	SPOP	0.9931	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4399:4403	ASTTS	SPOP	0.8322	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4431:4435	ASTTS	SPOP	0.6177	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4452:4456	ASTTS	SPOP	0.6169	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4503:4507	ASTTS	SPOP	0.9989	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4535:4539	ASTTS	SPOP	0.996	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	221:225	ASTTS	SPOP	0.9444	More...
Q08AD1	Calmodulin-regulated spectrin-associated protein 2	DEG_SPOP_SBC_1	1335:1339	ASTTS	SPOP	0.981	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	1555:1559	ASTTS	SPOP	0.9902	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	410:414	ASTTS	SPOP	0.9908	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	587:591	ASTTS	SPOP	0.9617	More...
Q8N1G2	Cap-specific mRNA	DEG_SPOP_SBC_1	45:49	ASTTS	SPOP	0.9982	More...
Q8TEV9	Guanine nucleotide exchange protein SMCR8	DEG_SPOP_SBC_1	281:285	ASTTS	SPOP	0.6442	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	616:620	ASTTS	SPOP	0.9558	More...
Q504T8	Midnolin	DEG_SPOP_SBC_1	248:252	ASTTS	SPOP	0.9838	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	878:882	ASTTS	SPOP	0.8808	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1017:1021	ASTTS	SPOP	0.5093	More...
Q96MY1	Nucleolar protein 4-like	DEG_SPOP_SBC_1	374:378	ASTTS	SPOP	0.9269	More...
Q49AM3	Tetratricopeptide repeat protein 31	DEG_SPOP_SBC_1	202:206	ASTTS	SPOP	0.7121	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASTTS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of ASTTS