DegronMD - Q08AD1(CAMSAP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q560H	TCGA-05-4427	LUAD	TCGA	IETPSIE	DEG_SCF_FBW7_2	548:554	Mutation rewiring degron network	0.1667
p.Q560H	DO23666	LUAD	ICGC	IETPSIE	DEG_SCF_FBW7_2	548:554	Mutation rewiring degron network	0.1667
p.E544K	TCGA-06-5416	GBM	TCGA	IETPSIE	DEG_SCF_FBW7_2	548:554	Mutation rewiring degron network	0.2222
p.E544K	DO10880	GBM	ICGC	IETPSIE	DEG_SCF_FBW7_2	548:554	Mutation rewiring degron network	0.2222
p.L697R	TCGA-AC-A23H	BRCA	TCGA	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.2222
p.L697R	DO2401	BRCA	ICGC	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.2222
p.S688G	TCGA-AJ-A23O	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.3056
p.S688G	DO43290	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.3056
p.H550N	TCGA-AJ-A3EL	UCEC	TCGA	IETPSIE	DEG_SCF_FBW7_2	548:554	Mutation altering degron motif	0.7423
p.R1003Q	TCGA-CM-6162	COAD	TCGA	LTPPRS	DEG_SCF_FBW7_1	1003:1008	Mutation altering degron motif	0.7329
p.R1003Q	DO8479	COAD	ICGC	LTPPRS	DEG_SCF_FBW7_1	1003:1008	Mutation altering degron motif	0.7329
p.P1002A	TCGA-D8-A147	BRCA	TCGA	LTPPRS	DEG_SCF_FBW7_1	1003:1008	Mutation blocking phosphorylation signal	0.75
p.P1002A	DO4347	BRCA	ICGC	LTPPRS	DEG_SCF_FBW7_1	1003:1008	Mutation blocking phosphorylation signal	0.75
p.T700A	TCGA-D8-A1XK	BRCA	TCGA	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.1389
p.N698K	TCGA-DU-6392	LGG	TCGA	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.1944
p.N698K	DO22237	LGG	ICGC	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.1944
p.R1003W	TCGA-JW-A5VL	CESC	TCGA	LTPPRS	DEG_SCF_FBW7_1	1003:1008	Mutation altering degron motif	0.8634
p.L1001F	TCGA-UF-A7JT	HNSC	TCGA	LTPPRS	DEG_SCF_FBW7_1	1003:1008	Mutation rewiring degron network	0.2778
p.P1013S	TCGA-W3-AA1W	SKCM	TCGA	LTPPRS	DEG_SCF_FBW7_1	1003:1008	Mutation rewiring degron network	0.1944
p.P1013S	DO222699	MELA	ICGC	LTPPRS	DEG_SCF_FBW7_1	1003:1008	Mutation rewiring degron network	0.1944
p.R1014W	DO49976	CESC	ICGC	LTPPRS	DEG_SCF_FBW7_1	1003:1008	Mutation rewiring degron network	0.1667
p.A556S	DO230311	COCA	ICGC	IETPSIE	DEG_SCF_FBW7_2	548:554	Mutation rewiring degron network	0.2778
p.E549K	DO230346	COCA	ICGC	IETPSIE	DEG_SCF_FBW7_2	548:554	Mutation altering degron motif	0.591
p.R1326Q	DO222884	COCA	ICGC	ASTTS	DEG_SPOP_SBC_1	1335:1339	Mutation rewiring degron network	0.0833
p.R1326Q	DO49073	UCEC	ICGC	ASTTS	DEG_SPOP_SBC_1	1335:1339	Mutation rewiring degron network	0.0833
p.R1001Q	DO219895	DLBC	ICGC	LTPPRS	DEG_SCF_FBW7_1	1003:1008	Mutation rewiring degron network	0.2778
p.L1012F	DO219090	HNSC	ICGC	LTPPRS	DEG_SCF_FBW7_1	1003:1008	Mutation rewiring degron network	0.2222
p.R1007L	DO229028	LICA	ICGC	LTPPRS	DEG_SCF_FBW7_1	1003:1008	Mutation altering degron motif	0.7316
p.R1326L	DO229008	LICA	ICGC	ASTTS	DEG_SPOP_SBC_1	1335:1339	Mutation rewiring degron network	0.0833
p.M697V	DO23519	LIRI	ICGC	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.2222
p.L541I	DO40884	UCEC	ICGC	IETPSIE	DEG_SCF_FBW7_2	548:554	Mutation rewiring degron network	0.1389
p.H561N	DO41542	UCEC	ICGC	IETPSIE	DEG_SCF_FBW7_2	548:554	Mutation rewiring degron network	0.1389
p.T698I	SIDM00403	T-Lymphoblastic Leukemia	GDSC	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.1944
p.T698I	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.1944
p.T698S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.1944
p.T698S	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.1944
p.K682T	SIDM00282	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation substituting flanking lysine	0.25
p.K682T	CW-2	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation substituting flanking lysine	0.25
p.A1335T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	ASTTS	DEG_SPOP_SBC_1	1335:1339	Mutation altering degron motif	0.7139
p.T687I	ACH-000636	Leukemia	CCLE	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.2778
p.T687I	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.2778
p.S541G	ACH-000961	Endometrial/Uterine Cancer	CCLE	IETPSIE	DEG_SCF_FBW7_2	548:554	Mutation rewiring degron network	0.1389
p.R695K	ACH-001065	Breast Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.2778
p.R695K	EVSA-T	breast	COSMIC	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.2778
p.T687S	ACH-002059	Leukemia	CCLE	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.2778
p.T687S	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.2778
p.R679K	EVSA-T	breast	COSMIC	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.0556
p.C1005Y	DND-41	haematopoietic and lymphoid tissue	COSMIC	LTPPRS	DEG_SCF_FBW7_1	1003:1008	Mutation altering degron motif	0.7087
p.S693F	SW872	soft tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	689:693	Mutation altering degron motif	0.7982
p.S564L	DU-145	prostate	COSMIC	IETPSIE	DEG_SCF_FBW7_2	548:554	Mutation rewiring degron network	0.0556
p.H555R	CCK-81	large intestine	COSMIC	IETPSIE	DEG_SCF_FBW7_2	548:554	Mutation rewiring degron network	0.3056

Kaplan plot for CAMSAP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CAMSAP2

UniProt ID: Q08AD1

Entrez ID: 23271

Protein name: Calmodulin-regulated spectrin-associated protein 2 (Calmodulin-regulated spectrin-associated protein 1-like protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CAMSAP2 in