DegronMD

Uniprot ID: Q08AD1

Source protein: Calmodulin-regulated spectrin-associated protein 2

Source gene: CAMSAP2

Class: DEG_SCF_FBW7_2

Location: 548:554

E3 ligase: FBXW7

DEGRON score: 0.9944

ASA_SCORE: 82.9714

COIL: 0.7296

CONS_SCORE: 0.4792

DSS_SCORE: 0.3961

HELIX: 0.249

FCONS_SCORE: 1.1422

RIG_SCORE: 0.7589

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q560H	TCGA-05-4427	LUAD	TCGA	IETPSIE	DEG_SCF_FBW7_2	0.1667
p.Q560H	DO23666	LUAD	ICGC	IETPSIE	DEG_SCF_FBW7_2	0.1667
p.E544K	TCGA-06-5416	GBM	TCGA	IETPSIE	DEG_SCF_FBW7_2	0.2222
p.E544K	DO10880	GBM	ICGC	IETPSIE	DEG_SCF_FBW7_2	0.2222
p.H550N	TCGA-AJ-A3EL	UCEC	TCGA	IETPSIE	DEG_SCF_FBW7_2	0.7423
p.A556S	DO230311	COCA	ICGC	IETPSIE	DEG_SCF_FBW7_2	0.2778
p.E549K	DO230346	COCA	ICGC	IETPSIE	DEG_SCF_FBW7_2	0.591
p.L541I	DO40884	UCEC	ICGC	IETPSIE	DEG_SCF_FBW7_2	0.1389
p.H561N	DO41542	UCEC	ICGC	IETPSIE	DEG_SCF_FBW7_2	0.1389
p.S541G	ACH-000961	Endometrial/Uterine Cancer	CCLE	IETPSIE	DEG_SCF_FBW7_2	0.1389
p.S564L	DU-145	prostate	COSMIC	IETPSIE	DEG_SCF_FBW7_2	0.0556
p.H555R	CCK-81	large_intestine	COSMIC	IETPSIE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08AD1	Calmodulin-regulated spectrin-associated protein 2	DEG_SCF_FBW7_2	548:554	IETPSIE	FBXW7	0.9944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons