DegronMD

Uniprot ID: Q08AD1

Source protein: Calmodulin-regulated spectrin-associated protein 2

Source gene: CAMSAP2

Class: DEG_SCF_FBW7_1

Location: 1003:1008

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 99.2833

COIL: 0.9632

CONS_SCORE: 0.3975

DSS_SCORE: 0.5597

HELIX: 0.0173

FCONS_SCORE: 0.8659

RIG_SCORE: 0.693

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1003Q	TCGA-CM-6162	COAD	TCGA	LTPPRS	DEG_SCF_FBW7_1	0.7329
p.R1003Q	DO8479	COAD	ICGC	LTPPRS	DEG_SCF_FBW7_1	0.7329
p.P1002A	TCGA-D8-A147	BRCA	TCGA	LTPPRS	DEG_SCF_FBW7_1	0.75
p.P1002A	DO4347	BRCA	ICGC	LTPPRS	DEG_SCF_FBW7_1	0.75
p.R1003W	TCGA-JW-A5VL	CESC	TCGA	LTPPRS	DEG_SCF_FBW7_1	0.8634
p.L1001F	TCGA-UF-A7JT	HNSC	TCGA	LTPPRS	DEG_SCF_FBW7_1	0.2778
p.P1013S	TCGA-W3-AA1W	SKCM	TCGA	LTPPRS	DEG_SCF_FBW7_1	0.1944
p.P1013S	DO222699	MELA	ICGC	LTPPRS	DEG_SCF_FBW7_1	0.1944
p.R1014W	DO49976	CESC	ICGC	LTPPRS	DEG_SCF_FBW7_1	0.1667
p.R1001Q	DO219895	DLBC	ICGC	LTPPRS	DEG_SCF_FBW7_1	0.2778
p.L1012F	DO219090	HNSC	ICGC	LTPPRS	DEG_SCF_FBW7_1	0.2222
p.R1007L	DO229028	LICA	ICGC	LTPPRS	DEG_SCF_FBW7_1	0.7316
p.C1005Y	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LTPPRS	DEG_SCF_FBW7_1	0.7087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20393	Nuclear receptor subfamily 1 group D member 1	DEG_SCF_FBW7_1	273:278	LTPPRS	FBXW7	0.8756	More...
Q08AD1	Calmodulin-regulated spectrin-associated protein 2	DEG_SCF_FBW7_1	1003:1008	LTPPRS	FBXW7	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons