DegronMD

Uniprot ID: P20393

Source protein: Nuclear receptor subfamily 1 group D member 1

Source gene: NR1D1

Class: DEG_SCF_FBW7_1

Location: 273:278

E3 ligase: FBXW7

DEGRON score: 0.8756

ASA_SCORE: 87.5667

COIL: 0.9678

CONS_SCORE: 0.415

DSS_SCORE: 0.7866

HELIX: 0.011

FCONS_SCORE: 0.9936

RIG_SCORE: 0.5781

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E282Q	TCGA-C8-A8HP	BRCA	TCGA	LTPPRS	DEG_SCF_FBW7_1	0.2222
p.E282Q	DO219621	BRCA	ICGC	LTPPRS	DEG_SCF_FBW7_1	0.2222
p.F269V	TCGA-CD-8527	STAD	TCGA	LTPPRS	DEG_SCF_FBW7_1	0.2222
p.F269V	DO47739	STAD	ICGC	LTPPRS	DEG_SCF_FBW7_1	0.2222
p.P283A	DO50443	ESAD	ICGC	LTPPRS	DEG_SCF_FBW7_1	0.1944
p.V288M	SIDM00867	Glioblastoma	GDSC	LTPPRS	DEG_SCF_FBW7_1	0.0556
p.V288M	ACH-000863	Brain Cancer	CCLE	LTPPRS	DEG_SCF_FBW7_1	0.0556
p.V288M	DBTRG-05MG	central_nervous_system	COSMIC	LTPPRS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20393	Nuclear receptor subfamily 1 group D member 1	DEG_SCF_FBW7_1	273:278	LTPPRS	FBXW7	0.8756	More...
Q08AD1	Calmodulin-regulated spectrin-associated protein 2	DEG_SCF_FBW7_1	1003:1008	LTPPRS	FBXW7	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons