DegronMD

Uniprot ID: Q06455

Source protein: Protein CBFA2T1

Source gene: RUNX1T1

Class: DEG_SPOP_SBC_1

Location: 221:225

E3 ligase: SPOP

DEGRON score: 0.9444

ASA_SCORE: 76.14

COIL: 0.8854

CONS_SCORE: 0.397

DSS_SCORE: 0.4367

HELIX: 0.078

FCONS_SCORE: 0.9118

RIG_SCORE: 0.665

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R212K	TCGA-06-5416	GBM	TCGA	ASTTS	DEG_SPOP_SBC_1	0.0833
p.A211T	TCGA-AP-A0LM	UCEC	TCGA	ASTTS	DEG_SPOP_SBC_1	0.0556
p.A211T	TCGA-AP-A1DK	UCEC	TCGA	ASTTS	DEG_SPOP_SBC_1	0.0556
p.A211T	TCGA-AZ-4315	COAD	TCGA	ASTTS	DEG_SPOP_SBC_1	0.0556
p.A211T	TCGA-E9-A22D	BRCA	TCGA	ASTTS	DEG_SPOP_SBC_1	0.0556
p.A211T	TCGA-XK-AAIW	PRAD	TCGA	ASTTS	DEG_SPOP_SBC_1	0.0556
p.H225R	TCGA-AX-A05Y	UCEC	TCGA	ASTTS	DEG_SPOP_SBC_1	0.8244
p.A232T	TCGA-AZ-6601	COAD	TCGA	ASTTS	DEG_SPOP_SBC_1	0.1389
p.Y221C	TCGA-DI-A1BU	UCEC	TCGA	ASTTS	DEG_SPOP_SBC_1	0.7087
p.A232V	TCGA-F4-6703	COAD	TCGA	ASTTS	DEG_SPOP_SBC_1	0.1389
p.A219V	TCGA-FI-A2D5	UCEC	TCGA	ASTTS	DEG_SPOP_SBC_1	0.2778
p.A219V	LCLC-103H	lung	COSMIC	ASTTS	DEG_SPOP_SBC_1	0.2778
p.Q220L	TCGA-QQ-A5VD	SARC	TCGA	ASTTS	DEG_SPOP_SBC_1	0.3056
p.A214V	TCGA-SL-A6JA	UCEC	TCGA	ASTTS	DEG_SPOP_SBC_1	0.1389
p.E211K	DO48566	BLCA	ICGC	ASTTS	DEG_SPOP_SBC_1	0.0556
p.E211K	DO514	BLCA	ICGC	ASTTS	DEG_SPOP_SBC_1	0.0556
p.E211K	DO14196	HNSC	ICGC	ASTTS	DEG_SPOP_SBC_1	0.0556
p.E211K	DO222434	MELA	ICGC	ASTTS	DEG_SPOP_SBC_1	0.0556
p.E211K	DO27943	ORCA	ICGC	ASTTS	DEG_SPOP_SBC_1	0.0556
p.E211K	DO37579	SKCM	ICGC	ASTTS	DEG_SPOP_SBC_1	0.0556
p.E211K	DO37851	SKCM	ICGC	ASTTS	DEG_SPOP_SBC_1	0.0556
p.E211K	DO37406	SKCM	ICGC	ASTTS	DEG_SPOP_SBC_1	0.0556
p.E211K	DO47343	SKCM	ICGC	ASTTS	DEG_SPOP_SBC_1	0.0556
p.E211K	DO223907	SKCM	ICGC	ASTTS	DEG_SPOP_SBC_1	0.0556
p.T221N	DO219592	BRCA	ICGC	ASTTS	DEG_SPOP_SBC_1	0.7055
p.N212D	DO8264	COAD	ICGC	ASTTS	DEG_SPOP_SBC_1	0.0833
p.R216Q	DO234219	ESAD	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1944
p.R216Q	DO10880	GBM	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1944
p.R216Q	DO26444	LUSC	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1944
p.R216Q	DO37839	SKCM	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1944
p.R216Q	DO37406	SKCM	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1944
p.R216Q	DO47401	SKCM	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1944
p.R216Q	DO51276	SKCM	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1944
p.R216Q	DO43202	UCEC	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1944
p.R216Q	DO41542	UCEC	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1944
p.R228I	DO50097	LUSC	ICGC	ASTTS	DEG_SPOP_SBC_1	0.25
p.R216L	DO26772	LUSC	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1944
p.E229D	DO27349	LUSC	ICGC	ASTTS	DEG_SPOP_SBC_1	0.2222
p.G213W	DO220877	MELA	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1111
p.R220K	DO37406	SKCM	ICGC	ASTTS	DEG_SPOP_SBC_1	0.3056
p.G225D	DO38747	STAD	ICGC	ASTTS	DEG_SPOP_SBC_1	0.7198
p.R220S	DO41758	UCEC	ICGC	ASTTS	DEG_SPOP_SBC_1	0.3056
p.R215M	DO42592	UCEC	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1667
p.E211A	DO42713	UCEC	ICGC	ASTTS	DEG_SPOP_SBC_1	0.0556
p.T220K	SIDM01265	Plasma Cell Myeloma	GDSC	ASTTS	DEG_SPOP_SBC_1	0.3056
p.T220K	MM1S	haematopoietic_and_lymphoid_tissue	COSMIC	ASTTS	DEG_SPOP_SBC_1	0.3056
p.L217M	ACH-000825	Lung Cancer	CCLE	ASTTS	DEG_SPOP_SBC_1	0.2222
p.L217M	HOP-92	lung	COSMIC	ASTTS	DEG_SPOP_SBC_1	0.2222
p.L218F	ACH-001199	Colon/Colorectal Cancer	CCLE	ASTTS	DEG_SPOP_SBC_1	0.25
p.L218F	SNU-C2B	large_intestine	COSMIC	ASTTS	DEG_SPOP_SBC_1	0.25
p.V227L	ACH-002302	Leukemia	CCLE	ASTTS	DEG_SPOP_SBC_1	0.2778
p.V227L	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	ASTTS	DEG_SPOP_SBC_1	0.2778
p.E211G	SNU-81	large_intestine	COSMIC	ASTTS	DEG_SPOP_SBC_1	0.0556
p.P218L	SW684	soft_tissue	COSMIC	ASTTS	DEG_SPOP_SBC_1	0.25
p.S227R	STS-0421	soft_tissue	COSMIC	ASTTS	DEG_SPOP_SBC_1	0.2778
p.L229F	SNU-C2B	large_intestine	COSMIC	ASTTS	DEG_SPOP_SBC_1	0.2222
p.L228M	HOP-92	lung	COSMIC	ASTTS	DEG_SPOP_SBC_1	0.25
p.E218G	SNU-81	large_intestine	COSMIC	ASTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SPOP_SBC_1	330:334	ASTTS	SPOP	0.9671	More...
O75037	Kinesin-like protein KIF21B	DEG_SPOP_SBC_1	852:856	ASTTS	SPOP	0.5162	More...
P30518	Vasopressin V2 receptor	DEG_SPOP_SBC_1	4:8	ASTTS	SPOP	0.9728	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2519:2523	ASTTS	SPOP	0.9843	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2642:2646	ASTTS	SPOP	0.8965	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2647:2651	ASTTS	SPOP	0.9326	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2679:2683	ASTTS	SPOP	0.8855	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2687:2691	ASTTS	SPOP	0.9172	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2759:2763	ASTTS	SPOP	0.9813	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2967:2971	ASTTS	SPOP	0.5274	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3055:3059	ASTTS	SPOP	0.8813	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3175:3179	ASTTS	SPOP	0.9626	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3758:3762	ASTTS	SPOP	0.9504	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4236:4240	ASTTS	SPOP	0.9789	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4367:4371	ASTTS	SPOP	0.9931	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4399:4403	ASTTS	SPOP	0.8322	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4431:4435	ASTTS	SPOP	0.6177	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4452:4456	ASTTS	SPOP	0.6169	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4503:4507	ASTTS	SPOP	0.9989	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4535:4539	ASTTS	SPOP	0.996	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	221:225	ASTTS	SPOP	0.9444	More...
Q08AD1	Calmodulin-regulated spectrin-associated protein 2	DEG_SPOP_SBC_1	1335:1339	ASTTS	SPOP	0.981	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	1555:1559	ASTTS	SPOP	0.9902	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	410:414	ASTTS	SPOP	0.9908	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	587:591	ASTTS	SPOP	0.9617	More...
Q8N1G2	Cap-specific mRNA	DEG_SPOP_SBC_1	45:49	ASTTS	SPOP	0.9982	More...
Q8TEV9	Guanine nucleotide exchange protein SMCR8	DEG_SPOP_SBC_1	281:285	ASTTS	SPOP	0.6442	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	616:620	ASTTS	SPOP	0.9558	More...
Q504T8	Midnolin	DEG_SPOP_SBC_1	248:252	ASTTS	SPOP	0.9838	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	878:882	ASTTS	SPOP	0.8808	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1017:1021	ASTTS	SPOP	0.5093	More...
Q96MY1	Nucleolar protein 4-like	DEG_SPOP_SBC_1	374:378	ASTTS	SPOP	0.9269	More...
Q49AM3	Tetratricopeptide repeat protein 31	DEG_SPOP_SBC_1	202:206	ASTTS	SPOP	0.7121	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASTTS

Degron related mutations and impact score

Drug responses associated with RUNX1T1 mutations

All proteins holding degron of ASTTS