DegronMD - P30518(AVPR2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C283R	TCGA-09-1675	OV	TCGA	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation rewiring degron network	0.1944
p.C283R	DO30320	OV	ICGC	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation rewiring degron network	0.1944
p.T273M	TCGA-2W-A8YY	CESC	TCGA	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation altering degron motif	0.6312
p.T273M	DO223732	CESC	ICGC	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation altering degron motif	0.6312
p.A4T	TCGA-56-7822	LUSC	TCGA	ASTTS	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7139
p.A4T	DO26638	LUSC	ICGC	ASTTS	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7139
p.K268N	TCGA-66-2773	LUSC	TCGA	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation rewiring degron network	0.2778
p.K268N	DO26536	LUSC	ICGC	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation rewiring degron network	0.2778
p.V262L	TCGA-69-7979	LUAD	TCGA	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation rewiring degron network	0.1111
p.V262L	DO23874	LUAD	ICGC	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation rewiring degron network	0.1111
p.L282R	TCGA-91-6829	LUAD	TCGA	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation rewiring degron network	0.2222
p.L282R	DO23564	LUAD	ICGC	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation rewiring degron network	0.2222
p.R271M	TCGA-DU-6392	LGG	TCGA	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation altering degron motif	0.8632
p.R271M	DO22237	LGG	ICGC	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation altering degron motif	0.8632
p.A264V	TCGA-FJ-A3Z7	BLCA	TCGA	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation rewiring degron network	0.1667
p.A264V	DO463	BLCA	ICGC	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation rewiring degron network	0.1667
p.A9T	TCGA-VQ-A91V	STAD	TCGA	ASTTS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.3056
p.A9T	DO228483	BRCA	ICGC	ASTTS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.3056
p.A9T	DO222356	STAD	ICGC	ASTTS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.3056
p.G12E	DO230334	COCA	ICGC	ASTTS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.2222
p.V279I	DO230342	COCA	ICGC	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation rewiring degron network	0.3056
p.V279I	DO233261	GACA	ICGC	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation rewiring degron network	0.3056
p.A9S	DO229026	LICA	ICGC	ASTTS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.3056
p.A9V	DO229050	LICA	ICGC	ASTTS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.3056
p.C283Y	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation rewiring degron network	0.1944
p.C283Y	ACH-000920	Leukemia	CCLE	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation rewiring degron network	0.1944
p.V270M	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation altering degron motif	0.6097
p.V270M	ACH-000920	Leukemia	CCLE	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation altering degron motif	0.6097
p.V270M	CML-T1	haematopoietic and lymphoid tissue	COSMIC	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation altering degron motif	0.6097
p.M3I	SIDM00329	Hodgkin's Lymphoma	GDSC	ASTTS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.3056
p.M3I	ACH-000806	Lymphoma	CCLE	ASTTS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.3056
p.M3I	L-540	haematopoietic and lymphoid tissue	COSMIC	ASTTS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.3056
p.V266A	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation rewiring degron network	0.2222
p.V266A	EMC-BAC-2	lung	COSMIC	VRMTLVIVV	DEG_APCC_DBOX_1	270:278	Mutation rewiring degron network	0.2222

Kaplan plot for AVPR2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AVPR2

UniProt ID: P30518

Entrez ID: 554

Protein name: Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AVPR2 in