DegronMD

Uniprot ID: P30518

Source protein: Vasopressin V2 receptor

Source gene: AVPR2

Class: DEG_APCC_DBOX_1

Location: 270:278

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8454

ASA_SCORE: 82.0111

COIL: 0.0891

CONS_SCORE: 0.75

DSS_SCORE: 0.0032

HELIX: 0.9001

FCONS_SCORE: 1.2627

RIG_SCORE: 1.0522

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C283R	TCGA-09-1675	OV	TCGA	VRMTLVIVV	DEG_APCC_DBOX_1	0.1944
p.C283R	DO30320	OV	ICGC	VRMTLVIVV	DEG_APCC_DBOX_1	0.1944
p.T273M	TCGA-2W-A8YY	CESC	TCGA	VRMTLVIVV	DEG_APCC_DBOX_1	0.6312
p.T273M	DO223732	CESC	ICGC	VRMTLVIVV	DEG_APCC_DBOX_1	0.6312
p.K268N	TCGA-66-2773	LUSC	TCGA	VRMTLVIVV	DEG_APCC_DBOX_1	0.2778
p.K268N	DO26536	LUSC	ICGC	VRMTLVIVV	DEG_APCC_DBOX_1	0.2778
p.V262L	TCGA-69-7979	LUAD	TCGA	VRMTLVIVV	DEG_APCC_DBOX_1	0.1111
p.V262L	DO23874	LUAD	ICGC	VRMTLVIVV	DEG_APCC_DBOX_1	0.1111
p.L282R	TCGA-91-6829	LUAD	TCGA	VRMTLVIVV	DEG_APCC_DBOX_1	0.2222
p.L282R	DO23564	LUAD	ICGC	VRMTLVIVV	DEG_APCC_DBOX_1	0.2222
p.R271M	TCGA-DU-6392	LGG	TCGA	VRMTLVIVV	DEG_APCC_DBOX_1	0.8632
p.R271M	DO22237	LGG	ICGC	VRMTLVIVV	DEG_APCC_DBOX_1	0.8632
p.A264V	TCGA-FJ-A3Z7	BLCA	TCGA	VRMTLVIVV	DEG_APCC_DBOX_1	0.1667
p.A264V	DO463	BLCA	ICGC	VRMTLVIVV	DEG_APCC_DBOX_1	0.1667
p.V279I	DO230342	COCA	ICGC	VRMTLVIVV	DEG_APCC_DBOX_1	0.3056
p.V279I	DO233261	GACA	ICGC	VRMTLVIVV	DEG_APCC_DBOX_1	0.3056
p.C283Y	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VRMTLVIVV	DEG_APCC_DBOX_1	0.1944
p.C283Y	ACH-000920	Leukemia	CCLE	VRMTLVIVV	DEG_APCC_DBOX_1	0.1944
p.V270M	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VRMTLVIVV	DEG_APCC_DBOX_1	0.6097
p.V270M	ACH-000920	Leukemia	CCLE	VRMTLVIVV	DEG_APCC_DBOX_1	0.6097
p.V270M	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VRMTLVIVV	DEG_APCC_DBOX_1	0.6097
p.V266A	SIDM00047	Non-Small Cell Lung Carcinoma	GDSC	VRMTLVIVV	DEG_APCC_DBOX_1	0.2222
p.V266A	EMC-BAC-2	lung	COSMIC	VRMTLVIVV	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30518	Vasopressin V2 receptor	DEG_APCC_DBOX_1	270:278	VRMTLVIVV	APC,CDC20,FZR1	0.8454	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons