DegronMD - Q504T8(MIDN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T239S	TCGA-44-4112	LUAD	TCGA	AASTT	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.0556
p.T239S	TCGA-44-4112	LUAD	TCGA	ASTTS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.0833
p.T239S	DO26032	LUAD	ICGC	AASTT	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.0556
p.T239S	DO26032	LUAD	ICGC	ASTTS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.0833
p.A357S	TCGA-55-8094	LUAD	TCGA	PRTTS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1667
p.A357S	DO24150	LUAD	ICGC	PRTTS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1667
p.A357S	SIDM00125	Kidney Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1667
p.A357S	ACH-000649	Kidney Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1667
p.A357S	786-0	kidney	COSMIC	PRTTS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1667
p.A225T	TCGA-D1-A167	UCEC	TCGA	AASTT	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.7139
p.A225T	DO233731	GACA	ICGC	AASTT	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.7139
p.A225T	DO40978	UCEC	ICGC	AASTT	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.7139
p.P258L	TCGA-D9-A4Z3	SKCM	TCGA	ASTTS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.1667
p.P258L	DO47555	SKCM	ICGC	ASTTS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.1667
p.S243N	TCGA-F7-A624	HNSC	TCGA	ASTTS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.1944
p.S243N	DO44440	HNSC	ICGC	ASTTS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.1944
p.A248V	TCGA-FI-A2D0	UCEC	TCGA	ASTTS	DEG_SPOP_SBC_1	248:252	Mutation altering degron motif	0.5825
p.A248V	DO43891	UCEC	ICGC	ASTTS	DEG_SPOP_SBC_1	248:252	Mutation altering degron motif	0.5825
p.A248V	SIDM00930	Osteosarcoma	GDSC	ASTTS	DEG_SPOP_SBC_1	248:252	Mutation altering degron motif	0.5825
p.S257N	DO222692	ESCA	ICGC	ASTTS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.1944
p.R261L	DO228976	LICA	ICGC	ASTTS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.0833
p.S241I	DO229027	LICA	ICGC	ASTTS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.1389
p.A358G	DO51145	PRAD	ICGC	PRTTS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1389
p.C230Y	DO38663	STAD	ICGC	AASTT	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.3056
p.I216T	DO229181	THCA	ICGC	AASTT	DEG_SPOP_SBC_1	225:229	Mutation rewiring degron network	0.0833
p.T229A	SIDM00465	Ovarian Carcinoma	GDSC	AASTT	DEG_SPOP_SBC_1	225:229	Mutation altering degron motif	0.7139
p.A259P	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ASTTS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.1389
p.A259P	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	ASTTS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.1389
p.A339P	ACH-000951	Lung Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1111
p.R261S	ACH-001031	Rhabdoid	CCLE	ASTTS	DEG_SPOP_SBC_1	248:252	Mutation rewiring degron network	0.0833

Kaplan plot for MIDN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MIDN

UniProt ID: Q504T8

Entrez ID: 90007

Protein name: Midnolin (Midbrain nucleolar protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MIDN in