DegronMD

Uniprot ID: Q504T8

Source protein: Midnolin

Source gene: MIDN

Class: DEG_SPOP_SBC_1

Location: 347:351

E3 ligase: SPOP

DEGRON score: 0.9927

ASA_SCORE: 91.48

COIL: 0.911

CONS_SCORE: 0.5231

DSS_SCORE: 0.5121

HELIX: 0.052

FCONS_SCORE: 1.0362

RIG_SCORE: 0.7016

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A357S	TCGA-55-8094	LUAD	TCGA	PRTTS	DEG_SPOP_SBC_1	0.1667
p.A357S	DO24150	LUAD	ICGC	PRTTS	DEG_SPOP_SBC_1	0.1667
p.A357S	SIDM00125	Kidney Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.1667
p.A357S	ACH-000649	Kidney Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	0.1667
p.A357S	786-0	kidney	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.1667
p.A358G	DO51145	PRAD	ICGC	PRTTS	DEG_SPOP_SBC_1	0.1389
p.A339P	ACH-000951	Lung Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	0.1111

Showing 1 to 7 of 7 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6T7	Diacylglycerol kinase beta	DEG_SPOP_SBC_1	119:123	PRTTS	SPOP	0.711	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	618:622	PRTTS	SPOP	0.9725	More...
Q9Y2H0	Disks large-associated protein 4	DEG_SPOP_SBC_1	566:570	PRTTS	SPOP	0.9951	More...
P49841	Glycogen synthase kinase-3 beta	DEG_SPOP_SBC_1	5:9	PRTTS	SPOP	0.9966	More...
Q14678	KN motif and ankyrin repeat domain-containing protein 1	DEG_SPOP_SBC_1	76:80	PRTTS	SPOP	0.5682	More...
P50281	Matrix metalloproteinase-14	DEG_SPOP_SBC_1	297:301	PRTTS	SPOP	0.8919	More...
Q9ULD2	Microtubule-associated tumor suppressor 1	DEG_SPOP_SBC_1	602:606	PRTTS	SPOP	0.9839	More...
Q504T8	Midnolin	DEG_SPOP_SBC_1	347:351	PRTTS	SPOP	0.9927	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4014:4018	PRTTS	SPOP	0.8354	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	802:806	PRTTS	SPOP	0.9836	More...
Q96F83	Uncharacterized protein CLBA1	DEG_SPOP_SBC_1	110:114	PRTTS	SPOP	0.7739	More...

Showing 1 to 11 of 11 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons