DegronMD - Q14678(KANK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R67W	TCGA-32-2616	GBM	TCGA	PRTTS	DEG_SPOP_SBC_1	76:80	Mutation rewiring degron network	0.0833
p.R67W	DO13462	GBM	ICGC	PRTTS	DEG_SPOP_SBC_1	76:80	Mutation rewiring degron network	0.0833
p.P227L	TCGA-97-7547	LUAD	TCGA	APTTS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.2778
p.P227L	DO23594	LUAD	ICGC	APTTS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.2778
p.W86C	TCGA-B5-A3FC	UCEC	TCGA	PRTTS	DEG_SPOP_SBC_1	76:80	Mutation rewiring degron network	0.1667
p.W86C	DO41871	UCEC	ICGC	PRTTS	DEG_SPOP_SBC_1	76:80	Mutation rewiring degron network	0.1667
p.V71L	TCGA-CA-6719	COAD	TCGA	PRTTS	DEG_SPOP_SBC_1	76:80	Mutation rewiring degron network	0.1944
p.V71L	DO9234	COAD	ICGC	PRTTS	DEG_SPOP_SBC_1	76:80	Mutation rewiring degron network	0.1944
p.I85M	SIDM00480	Ovarian Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	76:80	Mutation rewiring degron network	0.1944
p.S80F	SIDM01175	Other Sarcomas	GDSC	PRTTS	DEG_SPOP_SBC_1	76:80	Mutation altering degron motif	0.7982
p.S80F	ACH-002309	Sarcoma	CCLE	PRTTS	DEG_SPOP_SBC_1	76:80	Mutation altering degron motif	0.7982
p.S80F	SW684	soft tissue	COSMIC	PRTTS	DEG_SPOP_SBC_1	76:80	Mutation altering degron motif	0.7982
p.P69L	SIDM01099	Neuroblastoma	GDSC	PRTTS	DEG_SPOP_SBC_1	76:80	Mutation rewiring degron network	0.1389
p.P69L	SIDM00863	Burkitt's Lymphoma	GDSC	PRTTS	DEG_SPOP_SBC_1	76:80	Mutation rewiring degron network	0.1389
p.V71M	SIDM00839	Colorectal Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	76:80	Mutation rewiring degron network	0.1944
p.V71M	ACH-000950	Colon/Colorectal Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	76:80	Mutation rewiring degron network	0.1944
p.V71M	LoVo	large intestine	COSMIC	PRTTS	DEG_SPOP_SBC_1	76:80	Mutation rewiring degron network	0.1944
p.E239G	NCC010	kidney	COSMIC	APTTS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1667
p.C240F	KURAMOCHI	ovary	COSMIC	APTTS	DEG_SPOP_SBC_1	229:233	Mutation rewiring degron network	0.1389

Kaplan plot for KANK1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KANK1

UniProt ID: Q14678

Entrez ID: 23189

Protein name: KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KANK1 in