DegronMD

Uniprot ID: P50281

Source protein: Matrix metalloproteinase-14

Source gene: MMP14

Class: DEG_SPOP_SBC_1

Location: 297:301

E3 ligase: SPOP

DEGRON score: 0.8919

ASA_SCORE: 100.56

COIL: 0.9548

CONS_SCORE: 0.3941

DSS_SCORE: 0.8155

HELIX: 0.0156

FCONS_SCORE: 1.1627

RIG_SCORE: 0.5864

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F289S	TCGA-AX-A1CE	UCEC	TCGA	PRTTS	DEG_SPOP_SBC_1	0.1111
p.F289S	DO42280	UCEC	ICGC	PRTTS	DEG_SPOP_SBC_1	0.1111
p.P290L	TCGA-HU-A4GX	STAD	TCGA	PRTTS	DEG_SPOP_SBC_1	0.1389
p.P290L	DO47757	STAD	ICGC	PRTTS	DEG_SPOP_SBC_1	0.1389
p.R302W	DO233259	GACA	ICGC	PRTTS	DEG_SPOP_SBC_1	0.3056
p.P309L	SIDM00216	Colorectal Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.1111
p.P309L	ACH-000989	Colon/Colorectal Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	0.1111
p.P309L	SNU-175	large_intestine	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.1111
p.P297S	SIDM00150	Colorectal Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.6752
p.P297S	ACH-000969	Colon/Colorectal Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	0.6752
p.P297S	KM12	large_intestine	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.6752
p.T299S	SIDM01033	Bladder Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.6005
p.T299S	ACH-000486	Bladder Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	0.6005
p.T299S	KU-19-19	urinary_tract	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49841	Glycogen synthase kinase-3 beta	DEG_SPOP_SBC_1	5:9	PRTTS	SPOP	0.9966	More...
P50281	Matrix metalloproteinase-14	DEG_SPOP_SBC_1	297:301	PRTTS	SPOP	0.8919	More...
Q14678	KN motif and ankyrin repeat domain-containing protein 1	DEG_SPOP_SBC_1	76:80	PRTTS	SPOP	0.5682	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4014:4018	PRTTS	SPOP	0.8354	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	618:622	PRTTS	SPOP	0.9725	More...
Q9ULD2	Microtubule-associated tumor suppressor 1	DEG_SPOP_SBC_1	602:606	PRTTS	SPOP	0.9839	More...
Q9Y2H0	Disks large-associated protein 4	DEG_SPOP_SBC_1	566:570	PRTTS	SPOP	0.9951	More...
Q9Y6T7	Diacylglycerol kinase beta	DEG_SPOP_SBC_1	119:123	PRTTS	SPOP	0.711	More...
Q504T8	Midnolin	DEG_SPOP_SBC_1	347:351	PRTTS	SPOP	0.9927	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	802:806	PRTTS	SPOP	0.9836	More...
Q96F83	Uncharacterized protein CLBA1	DEG_SPOP_SBC_1	110:114	PRTTS	SPOP	0.7739	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons