DegronMD

Uniprot ID: Q96F83

Source protein: Uncharacterized protein CLBA1

Source gene: CLBA1

Class: DEG_SPOP_SBC_1

Location: 110:114

E3 ligase: SPOP

DEGRON score: 0.7739

ASA_SCORE: 83.86

COIL: 0.8668

CONS_SCORE: 0.5063

DSS_SCORE: 0.7759

HELIX: 0.0778

FCONS_SCORE: 1.2086

RIG_SCORE: 0.6021

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P110L	SIDM00589	Oral Cavity Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.7582
p.P110L	SIDM01413	Oral Cavity Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.7582
p.P110L	HSC-3	upper_aerodigestive_tract	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49841	Glycogen synthase kinase-3 beta	DEG_SPOP_SBC_1	5:9	PRTTS	SPOP	0.9966	More...
P50281	Matrix metalloproteinase-14	DEG_SPOP_SBC_1	297:301	PRTTS	SPOP	0.8919	More...
Q14678	KN motif and ankyrin repeat domain-containing protein 1	DEG_SPOP_SBC_1	76:80	PRTTS	SPOP	0.5682	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4014:4018	PRTTS	SPOP	0.8354	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	618:622	PRTTS	SPOP	0.9725	More...
Q9ULD2	Microtubule-associated tumor suppressor 1	DEG_SPOP_SBC_1	602:606	PRTTS	SPOP	0.9839	More...
Q9Y2H0	Disks large-associated protein 4	DEG_SPOP_SBC_1	566:570	PRTTS	SPOP	0.9951	More...
Q9Y6T7	Diacylglycerol kinase beta	DEG_SPOP_SBC_1	119:123	PRTTS	SPOP	0.711	More...
Q504T8	Midnolin	DEG_SPOP_SBC_1	347:351	PRTTS	SPOP	0.9927	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	802:806	PRTTS	SPOP	0.9836	More...
Q96F83	Uncharacterized protein CLBA1	DEG_SPOP_SBC_1	110:114	PRTTS	SPOP	0.7739	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons