DegronMD - Q9Y6T7(DGKB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S123C	TCGA-34-8454	LUSC	TCGA	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.7541
p.S123C	DO50094	LUSC	ICGC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.7541
p.P118T	TCGA-64-1679	LUAD	TCGA	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation altering degron motif	0.7031
p.P118T	DO26200	LUAD	ICGC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation altering degron motif	0.7031
p.P118T	SIDM00792	Small Cell Lung Carcinoma	GDSC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation altering degron motif	0.7031
p.P118T	ACH-002170	Lung Cancer	CCLE	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation altering degron motif	0.7031
p.P118T	NCI-H1688	lung	COSMIC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation altering degron motif	0.7031
p.T127M	TCGA-AP-A1E0	UCEC	TCGA	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1667
p.T127M	TCGA-AP-A1E0	UCEC	TCGA	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.2222
p.T127M	TCGA-BR-4184	STAD	TCGA	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1667
p.T127M	TCGA-BR-4184	STAD	TCGA	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.2222
p.T127M	DO50446	ESAD	ICGC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1667
p.T127M	DO50446	ESAD	ICGC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.2222
p.T127M	DO38328	STAD	ICGC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1667
p.T127M	DO38328	STAD	ICGC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.2222
p.T127M	DO43154	UCEC	ICGC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1667
p.T127M	DO43154	UCEC	ICGC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.2222
p.S123Y	TCGA-AX-A2HC	UCEC	TCGA	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.712
p.S123Y	TCGA-BS-A0UF	UCEC	TCGA	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.712
p.S123Y	DO222762	COCA	ICGC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.712
p.S123Y	DO41572	UCEC	ICGC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.712
p.S123Y	DO41488	UCEC	ICGC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.712
p.S123Y	SIDM01588	Endometrial Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.712
p.S123Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.712
p.R120W	TCGA-B5-A3FA	UCEC	TCGA	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation altering degron motif	0.7523
p.R120W	TCGA-B5-A3FA	UCEC	TCGA	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.7523
p.R120W	DO52402	UCEC	ICGC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation altering degron motif	0.7523
p.R120W	DO52402	UCEC	ICGC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.7523
p.I116N	TCGA-BP-5173	KIRC	TCGA	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation altering degron motif	0.728
p.I116N	DO20289	KIRC	ICGC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation altering degron motif	0.728
p.K113T	TCGA-E6-A1M0	UCEC	TCGA	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation blocking ubiquitination signal	0.6944
p.K113T	TCGA-E6-A1M0	UCEC	TCGA	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation blocking ubiquitination signal	0.6111
p.K113T	DO43682	UCEC	ICGC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation blocking ubiquitination signal	0.6944
p.K113T	DO43682	UCEC	ICGC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation blocking ubiquitination signal	0.6111
p.P119A	TCGA-O2-A52Q	LUSC	TCGA	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation altering degron motif	0.6392
p.P119A	TCGA-O2-A52Q	LUSC	TCGA	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.6392
p.P119A	DO219219	LUSC	ICGC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation altering degron motif	0.6392
p.P119A	DO219219	LUSC	ICGC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.6392
p.A125V	DO228732	GACA	ICGC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.2222
p.A125V	DO228732	GACA	ICGC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.2778
p.T121N	DO229041	LICA	ICGC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation altering degron motif	0.7055
p.T121N	DO229041	LICA	ICGC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.7055
p.P130S	DO220912	MELA	ICGC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.0833
p.P130S	DO220912	MELA	ICGC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1389
p.S129F	SIDM00422	Hodgkin's Lymphoma	GDSC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1111
p.S129F	SIDM00422	Hodgkin's Lymphoma	GDSC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1667
p.S129F	ACH-001203	Lymphoma	CCLE	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1111
p.S129F	ACH-001203	Lymphoma	CCLE	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1667
p.S129F	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1111
p.S129F	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1667
p.T127K	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1667
p.T127K	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.2222
p.T127K	ACH-002243	Esophageal Cancer	CCLE	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1667
p.T127K	ACH-002243	Esophageal Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.2222
p.T127K	GB-1	central nervous system	COSMIC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1667
p.T127K	GB-1	central nervous system	COSMIC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.2222
p.T127K	HCE-4	oesophagus	COSMIC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1667
p.T127K	HCE-4	oesophagus	COSMIC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.2222
p.N126K	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1944
p.N126K	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.25
p.N126K	ACH-002243	Esophageal Cancer	CCLE	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1944
p.N126K	ACH-002243	Esophageal Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.25
p.N126K	HCE-4	oesophagus	COSMIC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1944
p.N126K	HCE-4	oesophagus	COSMIC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.25
p.N126K	GB-1	central nervous system	COSMIC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1944
p.N126K	GB-1	central nervous system	COSMIC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.25
p.M111I	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1944
p.M111I	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1111
p.M111I	ACH-000904	Lung Cancer	CCLE	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1944
p.M111I	ACH-000904	Lung Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1111
p.M111I	ACH-001362	Lung Cancer	CCLE	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1944
p.M111I	ACH-001362	Lung Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1111
p.M111I	NCI-H1770	lung	COSMIC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1944
p.M111I	NCI-H1770	lung	COSMIC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1111
p.T117N	SIDM01347	Ovarian Carcinoma	GDSC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation altering degron motif	0.7055
p.T117N	ACH-000701	Ovarian Cancer	CCLE	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation altering degron motif	0.7055
p.P111T	NCI-H1688	lung	COSMIC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation rewiring degron network	0.1944
p.P111T	NCI-H1688	lung	COSMIC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation rewiring degron network	0.1111
p.N119K	GB-1	central nervous system	COSMIC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation altering degron motif	0.6918
p.N119K	GB-1	central nervous system	COSMIC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.6918
p.N119K	HCE-4	oesophagus	COSMIC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation altering degron motif	0.6918
p.N119K	HCE-4	oesophagus	COSMIC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.6918
p.T120K	GB-1	central nervous system	COSMIC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation altering degron motif	0.7306
p.T120K	GB-1	central nervous system	COSMIC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.7306
p.T120K	HCE-4	oesophagus	COSMIC	ITPPRT	DEG_SCF_FBW7_1	116:121	Mutation altering degron motif	0.7306
p.T120K	HCE-4	oesophagus	COSMIC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.7306
p.S122F	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	PRTTS	DEG_SPOP_SBC_1	119:123	Mutation altering degron motif	0.7982

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DGKB

UniProt ID: Q9Y6T7

Entrez ID: 1607

Protein name: Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DGKB in