DegronMD

Uniprot ID: Q9Y6T7

Source protein: Diacylglycerol kinase beta

Source gene: DGKB

Class: DEG_SCF_FBW7_1

Location: 116:121

E3 ligase: FBXW7

DEGRON score: 0.7052

ASA_SCORE: 104.95

COIL: 0.9522

CONS_SCORE: 0.2324

DSS_SCORE: 0.5967

HELIX: 0.0118

FCONS_SCORE: 1.0183

RIG_SCORE: 0.6846

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P118T	TCGA-64-1679	LUAD	TCGA	ITPPRT	DEG_SCF_FBW7_1	0.7031
p.P118T	DO26200	LUAD	ICGC	ITPPRT	DEG_SCF_FBW7_1	0.7031
p.P118T	SIDM00792	Small Cell Lung Carcinoma	GDSC	ITPPRT	DEG_SCF_FBW7_1	0.7031
p.P118T	ACH-002170	Lung Cancer	CCLE	ITPPRT	DEG_SCF_FBW7_1	0.7031
p.P118T	NCI-H1688	lung	COSMIC	ITPPRT	DEG_SCF_FBW7_1	0.7031
p.T127M	TCGA-AP-A1E0	UCEC	TCGA	ITPPRT	DEG_SCF_FBW7_1	0.1667
p.T127M	TCGA-BR-4184	STAD	TCGA	ITPPRT	DEG_SCF_FBW7_1	0.1667
p.T127M	DO50446	ESAD	ICGC	ITPPRT	DEG_SCF_FBW7_1	0.1667
p.T127M	DO38328	STAD	ICGC	ITPPRT	DEG_SCF_FBW7_1	0.1667
p.T127M	DO43154	UCEC	ICGC	ITPPRT	DEG_SCF_FBW7_1	0.1667
p.R120W	TCGA-B5-A3FA	UCEC	TCGA	ITPPRT	DEG_SCF_FBW7_1	0.7523
p.R120W	DO52402	UCEC	ICGC	ITPPRT	DEG_SCF_FBW7_1	0.7523
p.I116N	TCGA-BP-5173	KIRC	TCGA	ITPPRT	DEG_SCF_FBW7_1	0.728
p.I116N	DO20289	KIRC	ICGC	ITPPRT	DEG_SCF_FBW7_1	0.728
p.K113T	TCGA-E6-A1M0	UCEC	TCGA	ITPPRT	DEG_SCF_FBW7_1	0.6944
p.K113T	DO43682	UCEC	ICGC	ITPPRT	DEG_SCF_FBW7_1	0.6944
p.P119A	TCGA-O2-A52Q	LUSC	TCGA	ITPPRT	DEG_SCF_FBW7_1	0.6392
p.P119A	DO219219	LUSC	ICGC	ITPPRT	DEG_SCF_FBW7_1	0.6392
p.A125V	DO228732	GACA	ICGC	ITPPRT	DEG_SCF_FBW7_1	0.2222
p.T121N	DO229041	LICA	ICGC	ITPPRT	DEG_SCF_FBW7_1	0.7055
p.P130S	DO220912	MELA	ICGC	ITPPRT	DEG_SCF_FBW7_1	0.0833
p.S129F	SIDM00422	Hodgkin's Lymphoma	GDSC	ITPPRT	DEG_SCF_FBW7_1	0.1111
p.S129F	ACH-001203	Lymphoma	CCLE	ITPPRT	DEG_SCF_FBW7_1	0.1111
p.S129F	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	ITPPRT	DEG_SCF_FBW7_1	0.1111
p.T127K	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	ITPPRT	DEG_SCF_FBW7_1	0.1667
p.T127K	ACH-002243	Esophageal Cancer	CCLE	ITPPRT	DEG_SCF_FBW7_1	0.1667
p.T127K	GB-1	central_nervous_system	COSMIC	ITPPRT	DEG_SCF_FBW7_1	0.1667
p.T127K	HCE-4	oesophagus	COSMIC	ITPPRT	DEG_SCF_FBW7_1	0.1667
p.N126K	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	ITPPRT	DEG_SCF_FBW7_1	0.1944
p.N126K	ACH-002243	Esophageal Cancer	CCLE	ITPPRT	DEG_SCF_FBW7_1	0.1944
p.N126K	HCE-4	oesophagus	COSMIC	ITPPRT	DEG_SCF_FBW7_1	0.1944
p.N126K	GB-1	central_nervous_system	COSMIC	ITPPRT	DEG_SCF_FBW7_1	0.1944
p.M111I	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	ITPPRT	DEG_SCF_FBW7_1	0.1944
p.M111I	ACH-000904	Lung Cancer	CCLE	ITPPRT	DEG_SCF_FBW7_1	0.1944
p.M111I	ACH-001362	Lung Cancer	CCLE	ITPPRT	DEG_SCF_FBW7_1	0.1944
p.M111I	NCI-H1770	lung	COSMIC	ITPPRT	DEG_SCF_FBW7_1	0.1944
p.T117N	SIDM01347	Ovarian Carcinoma	GDSC	ITPPRT	DEG_SCF_FBW7_1	0.7055
p.T117N	ACH-000701	Ovarian Cancer	CCLE	ITPPRT	DEG_SCF_FBW7_1	0.7055
p.P111T	NCI-H1688	lung	COSMIC	ITPPRT	DEG_SCF_FBW7_1	0.1944
p.N119K	GB-1	central_nervous_system	COSMIC	ITPPRT	DEG_SCF_FBW7_1	0.6918
p.N119K	HCE-4	oesophagus	COSMIC	ITPPRT	DEG_SCF_FBW7_1	0.6918
p.T120K	GB-1	central_nervous_system	COSMIC	ITPPRT	DEG_SCF_FBW7_1	0.7306
p.T120K	HCE-4	oesophagus	COSMIC	ITPPRT	DEG_SCF_FBW7_1	0.7306

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ITPPRT

Degron related mutations and impact score

Drug responses associated with DGKB mutations

All proteins holding degron of ITPPRT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6T7	Diacylglycerol kinase beta	DEG_SCF_FBW7_1	116:121	ITPPRT	FBXW7	0.7052	More...