DegronMD

Uniprot ID: Q9ULD2

Source protein: Microtubule-associated tumor suppressor 1

Source gene: MTUS1

Class: DEG_SPOP_SBC_1

Location: 602:606

E3 ligase: SPOP

DEGRON score: 0.9839

ASA_SCORE: 100.68

COIL: 0.9054

CONS_SCORE: 0.446

DSS_SCORE: 0.6703

HELIX: 0.0684

FCONS_SCORE: 1.0694

RIG_SCORE: 0.6957

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A607T	TCGA-AB-2807	LAML	TCGA	PRTTS	DEG_SPOP_SBC_1	0.3056
p.A607T	DO21589	LAML	ICGC	PRTTS	DEG_SPOP_SBC_1	0.3056
p.E613A	TCGA-GC-A3WC	BLCA	TCGA	PRTTS	DEG_SPOP_SBC_1	0.1389
p.E613A	DO755	BLCA	ICGC	PRTTS	DEG_SPOP_SBC_1	0.1389
p.D614N	DO234435	ESAD	ICGC	PRTTS	DEG_SPOP_SBC_1	0.1111
p.T604R	DO230990	LUSC	ICGC	PRTTS	DEG_SPOP_SBC_1	0.7876
p.T604R	DO224554	LUSC	ICGC	PRTTS	DEG_SPOP_SBC_1	0.7876
p.R600G	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.2778
p.R600G	SIDM01039	Other Solid Cancers	GDSC	PRTTS	DEG_SPOP_SBC_1	0.2778
p.R600G	SIDM01525	Acute Myeloid Leukemia	GDSC	PRTTS	DEG_SPOP_SBC_1	0.2778
p.A607P	SIDM01041	Esophageal Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.3056
p.A607P	ACH-001500	Esophageal Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	0.3056
p.A607P	FLO-1	oesophagus	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.3056
p.K609Q	SIDM00364	B-Lymphoblastic Leukemia	GDSC	PRTTS	DEG_SPOP_SBC_1	0.3611
p.K609Q	SIDM00568	Gastric Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.3611
p.K609Q	SIDM00817	Kidney Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.3611
p.K609Q	SIDM00274	Gastric Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.3611
p.K609Q	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.3611
p.P602A	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.6392
p.P602A	ACH-000951	Lung Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	0.6392
p.P602A	NCI-H2342	lung	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.6392

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49841	Glycogen synthase kinase-3 beta	DEG_SPOP_SBC_1	5:9	PRTTS	SPOP	0.9966	More...
P50281	Matrix metalloproteinase-14	DEG_SPOP_SBC_1	297:301	PRTTS	SPOP	0.8919	More...
Q14678	KN motif and ankyrin repeat domain-containing protein 1	DEG_SPOP_SBC_1	76:80	PRTTS	SPOP	0.5682	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4014:4018	PRTTS	SPOP	0.8354	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	618:622	PRTTS	SPOP	0.9725	More...
Q9ULD2	Microtubule-associated tumor suppressor 1	DEG_SPOP_SBC_1	602:606	PRTTS	SPOP	0.9839	More...
Q9Y2H0	Disks large-associated protein 4	DEG_SPOP_SBC_1	566:570	PRTTS	SPOP	0.9951	More...
Q9Y6T7	Diacylglycerol kinase beta	DEG_SPOP_SBC_1	119:123	PRTTS	SPOP	0.711	More...
Q504T8	Midnolin	DEG_SPOP_SBC_1	347:351	PRTTS	SPOP	0.9927	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	802:806	PRTTS	SPOP	0.9836	More...
Q96F83	Uncharacterized protein CLBA1	DEG_SPOP_SBC_1	110:114	PRTTS	SPOP	0.7739	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons