DegronMD

Uniprot ID: Q504T8

Source protein: Midnolin

Source gene: MIDN

Class: DEG_SPOP_SBC_1

Location: 248:252

E3 ligase: SPOP

DEGRON score: 0.9838

ASA_SCORE: 83.84

COIL: 0.939

CONS_SCORE: 0.5645

DSS_SCORE: 0.6693

HELIX: 0.0194

FCONS_SCORE: 1.0396

RIG_SCORE: 0.5285

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T239S	TCGA-44-4112	LUAD	TCGA	ASTTS	DEG_SPOP_SBC_1	0.0833
p.T239S	DO26032	LUAD	ICGC	ASTTS	DEG_SPOP_SBC_1	0.0833
p.P258L	TCGA-D9-A4Z3	SKCM	TCGA	ASTTS	DEG_SPOP_SBC_1	0.1667
p.P258L	DO47555	SKCM	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1667
p.S243N	TCGA-F7-A624	HNSC	TCGA	ASTTS	DEG_SPOP_SBC_1	0.1944
p.S243N	DO44440	HNSC	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1944
p.A248V	TCGA-FI-A2D0	UCEC	TCGA	ASTTS	DEG_SPOP_SBC_1	0.5825
p.A248V	DO43891	UCEC	ICGC	ASTTS	DEG_SPOP_SBC_1	0.5825
p.A248V	SIDM00930	Osteosarcoma	GDSC	ASTTS	DEG_SPOP_SBC_1	0.5825
p.S257N	DO222692	ESCA	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1944
p.R261L	DO228976	LICA	ICGC	ASTTS	DEG_SPOP_SBC_1	0.0833
p.S241I	DO229027	LICA	ICGC	ASTTS	DEG_SPOP_SBC_1	0.1389
p.A259P	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ASTTS	DEG_SPOP_SBC_1	0.1389
p.A259P	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	ASTTS	DEG_SPOP_SBC_1	0.1389
p.R261S	ACH-001031	Rhabdoid	CCLE	ASTTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SPOP_SBC_1	330:334	ASTTS	SPOP	0.9671	More...
O75037	Kinesin-like protein KIF21B	DEG_SPOP_SBC_1	852:856	ASTTS	SPOP	0.5162	More...
P30518	Vasopressin V2 receptor	DEG_SPOP_SBC_1	4:8	ASTTS	SPOP	0.9728	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2519:2523	ASTTS	SPOP	0.9843	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2642:2646	ASTTS	SPOP	0.8965	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2647:2651	ASTTS	SPOP	0.9326	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2679:2683	ASTTS	SPOP	0.8855	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2687:2691	ASTTS	SPOP	0.9172	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2759:2763	ASTTS	SPOP	0.9813	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2967:2971	ASTTS	SPOP	0.5274	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3055:3059	ASTTS	SPOP	0.8813	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3175:3179	ASTTS	SPOP	0.9626	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3758:3762	ASTTS	SPOP	0.9504	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4236:4240	ASTTS	SPOP	0.9789	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4367:4371	ASTTS	SPOP	0.9931	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4399:4403	ASTTS	SPOP	0.8322	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4431:4435	ASTTS	SPOP	0.6177	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4452:4456	ASTTS	SPOP	0.6169	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4503:4507	ASTTS	SPOP	0.9989	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	4535:4539	ASTTS	SPOP	0.996	More...
Q06455	Protein CBFA2T1	DEG_SPOP_SBC_1	221:225	ASTTS	SPOP	0.9444	More...
Q08AD1	Calmodulin-regulated spectrin-associated protein 2	DEG_SPOP_SBC_1	1335:1339	ASTTS	SPOP	0.981	More...
Q12955	Ankyrin-3	DEG_SPOP_SBC_1	1555:1559	ASTTS	SPOP	0.9902	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	410:414	ASTTS	SPOP	0.9908	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	587:591	ASTTS	SPOP	0.9617	More...
Q8N1G2	Cap-specific mRNA	DEG_SPOP_SBC_1	45:49	ASTTS	SPOP	0.9982	More...
Q8TEV9	Guanine nucleotide exchange protein SMCR8	DEG_SPOP_SBC_1	281:285	ASTTS	SPOP	0.6442	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	616:620	ASTTS	SPOP	0.9558	More...
Q504T8	Midnolin	DEG_SPOP_SBC_1	248:252	ASTTS	SPOP	0.9838	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	878:882	ASTTS	SPOP	0.8808	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1017:1021	ASTTS	SPOP	0.5093	More...
Q96MY1	Nucleolar protein 4-like	DEG_SPOP_SBC_1	374:378	ASTTS	SPOP	0.9269	More...
Q49AM3	Tetratricopeptide repeat protein 31	DEG_SPOP_SBC_1	202:206	ASTTS	SPOP	0.7121	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASTTS

Degron related mutations and impact score

Drug responses associated with MIDN mutations

All proteins holding degron of ASTTS