DegronMD - Q9H4A3(WNK1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H850R	TCGA-18-3411	LUSC	TCGA	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation altering degron motif	0.7133
p.A1351V	TCGA-23-1117	OV	TCGA	PATSS	DEG_SPOP_SBC_1	1357:1361	Mutation rewiring degron network	0.1667
p.R81P	TCGA-43-5668	LUSC	TCGA	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1111
p.R81P	DO26608	LUSC	ICGC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1111
p.Q838E	TCGA-4Z-AA7M	BLCA	TCGA	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.1389
p.R1109L	TCGA-52-7809	LUSC	TCGA	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation rewiring degron network	0.1389
p.H2251P	TCGA-5P-A9K2	KIRP	TCGA	AMTSS	DEG_SPOP_SBC_1	2237:2241	Mutation rewiring degron network	0.0556
p.S1550C	TCGA-60-2713	LUSC	TCGA	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation altering degron motif	0.7541
p.T160N	TCGA-78-8640	LUAD	TCGA	VPSST	DEG_SPOP_SBC_1	156:160	Mutation altering degron motif	0.7055
p.T160N	DO45340	LUAD	ICGC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation altering degron motif	0.7055
p.E1901D	TCGA-85-6561	LUSC	TCGA	VLSSS	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.25
p.S1444N	TCGA-85-8049	LUSC	TCGA	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.1389
p.V1086I	TCGA-A5-A0G2	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation altering degron motif	0.7076
p.V1086I	ACH-000500	Head and Neck Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation altering degron motif	0.7076
p.V1734A	TCGA-A5-A0VP	UCEC	TCGA	VSTPVST	DEG_SCF_FBW7_1	1734:1740	Mutation altering degron motif	0.6936
p.S1491L	TCGA-A8-A0A7	BRCA	TCGA	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation rewiring degron network	0.1389
p.S1491L	TCGA-A8-A0A7	BRCA	TCGA	VSTTT	DEG_SPOP_SBC_1	1492:1496	Mutation rewiring degron network	0.3056
p.T856A	TCGA-AJ-A3EL	UCEC	TCGA	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.2222
p.G612D	TCGA-AP-A0LM	UCEC	TCGA	ASTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.2222
p.E1439D	TCGA-AP-A0LM	UCEC	TCGA	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.2778
p.S651F	TCGA-AP-A1DK	UCEC	TCGA	DSGQGSS	DEG_SCF_TRCP1_1	656:662	Mutation rewiring degron network	0.1944
p.P981S	TCGA-AP-A1DK	UCEC	TCGA	IAPSSNVASVCI	DEG_ODPH_VHL_1	960:971	Mutation rewiring degron network	0.0556
p.R1109H	TCGA-AP-A1DV	UCEC	TCGA	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation rewiring degron network	0.1389
p.S1080N	TCGA-AX-A0J0	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation rewiring degron network	0.1667
p.S1080N	SW48	large intestine	COSMIC	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation rewiring degron network	0.1667
p.L942M	TCGA-AX-A0J1	UCEC	TCGA	PPQY	ITCH	951:954	Mutation rewiring degron network	0.0833
p.S671I	TCGA-AX-A1CE	UCEC	TCGA	DSGQGSS	DEG_SCF_TRCP1_1	656:662	Mutation rewiring degron network	0.0833
p.S671I	TCGA-ZJ-AAX4	CESC	TCGA	DSGQGSS	DEG_SCF_TRCP1_1	656:662	Mutation rewiring degron network	0.0833
p.S671I	DO219750	CESC	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	656:662	Mutation rewiring degron network	0.0833
p.S671I	DO42280	UCEC	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	656:662	Mutation rewiring degron network	0.0833
p.L1489I	TCGA-B5-A0JU	UCEC	TCGA	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation rewiring degron network	0.1944
p.L1489I	TCGA-B5-A0JU	UCEC	TCGA	VSTTT	DEG_SPOP_SBC_1	1492:1496	Mutation rewiring degron network	0.25
p.R949Q	TCGA-B5-A0JY	UCEC	TCGA	PPQY	ITCH	951:954	Mutation rewiring degron network	0.2778
p.S1476Y	TCGA-B5-A0JY	UCEC	TCGA	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation rewiring degron network	0.2222
p.S1367P	TCGA-B5-A3FC	UCEC	TCGA	PATSS	DEG_SPOP_SBC_1	1357:1361	Mutation rewiring degron network	0.1667
p.T1445A	TCGA-BR-8081	STAD	TCGA	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.1111
p.D62G	TCGA-BR-8680	STAD	TCGA	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1389
p.D62G	DO47769	STAD	ICGC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1389
p.G1539A	TCGA-CR-7388	HNSC	TCGA	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.1389
p.R1100W	TCGA-D1-A17M	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation rewiring degron network	0.0556
p.P1087T	TCGA-D3-A2J6	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation altering degron motif	0.5919
p.P1087T	TCGA-GN-A26C	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation altering degron motif	0.5919
p.P840T	TCGA-D3-A2JB	SKCM	TCGA	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.1944
p.H59N	TCGA-D3-A2JG	SKCM	TCGA	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.H59N	DO47613	SKCM	ICGC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.S1476F	TCGA-D3-A3MV	SKCM	TCGA	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation rewiring degron network	0.2222
p.D635V	TCGA-DI-A1BU	UCEC	TCGA	EPEEPEADQH	DEG_Kelch_KLHL3_1	628:637	Mutation altering degron motif	0.7785
p.D635V	DO42023	UCEC	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	628:637	Mutation altering degron motif	0.7785
p.P948S	TCGA-DU-5855	LGG	TCGA	PPQY	ITCH	951:954	Mutation rewiring degron network	0.25
p.P948S	SIDM00845	Burkitt's Lymphoma	GDSC	PPQY	ITCH	951:954	Mutation rewiring degron network	0.25
p.P948S	SIDM00461	Acute Myeloid Leukemia	GDSC	PPQY	ITCH	951:954	Mutation rewiring degron network	0.25
p.P948S	SIDM01519	Head and Neck Carcinoma	GDSC	PPQY	ITCH	951:954	Mutation rewiring degron network	0.25
p.P948S	ACH-000786	Lymphoma	CCLE	PPQY	ITCH	951:954	Mutation rewiring degron network	0.25
p.P1471L	TCGA-DU-8158	LGG	TCGA	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation rewiring degron network	0.0833
p.A2237P	TCGA-DX-AB2Q	SARC	TCGA	AMTSS	DEG_SPOP_SBC_1	2237:2241	Mutation altering degron motif	0.6392
p.S1497L	TCGA-EB-A41B	SKCM	TCGA	VSTTT	DEG_SPOP_SBC_1	1492:1496	Mutation rewiring degron network	0.3056
p.P979L	TCGA-EE-A2MJ	SKCM	TCGA	IAPSSNVASVCI	DEG_ODPH_VHL_1	960:971	Mutation rewiring degron network	0.1111
p.R1111Q	TCGA-EO-A22R	UCEC	TCGA	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation rewiring degron network	0.1944
p.S1482N	TCGA-EO-A22U	UCEC	TCGA	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation altering degron motif	0.7069
p.S731L	TCGA-FR-A3YO	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.1944
p.S731L	TCGA-ZF-AA4X	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.1944
p.P1087Q	TCGA-FS-A1ZB	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation altering degron motif	0.5924
p.L1544F	TCGA-FW-A3R5	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.2778
p.A1480T	TCGA-G4-6588	COAD	TCGA	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation altering degron motif	0.7139
p.S732C	TCGA-GU-A767	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.1667
p.T74A	TCGA-GV-A6ZA	BLCA	TCGA	AATTT	DEG_SPOP_SBC_1	69:73	Mutation blocking phosphorylation signal	0.75
p.T74A	DO49776	BLCA	ICGC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation blocking phosphorylation signal	0.75
p.S1743L	TCGA-HU-A4GQ	STAD	TCGA	VSTPVST	DEG_SCF_FBW7_1	1734:1740	Mutation rewiring degron network	0.25
p.S1743L	TCGA-HU-A4GQ	STAD	TCGA	PVSTT	DEG_SPOP_SBC_1	1737:1741	Mutation rewiring degron network	0.2778
p.S1558C	TCGA-MT-A51W	HNSC	TCGA	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.1111
p.R668Q	TCGA-N5-A4RF	UCS	TCGA	DSGQGSS	DEG_SCF_TRCP1_1	656:662	Mutation rewiring degron network	0.1667
p.G945C	TCGA-NC-A5HG	LUSC	TCGA	PPQY	ITCH	951:954	Mutation rewiring degron network	0.1667
p.A1354T	TCGA-NH-A5IV	COAD	TCGA	PATSS	DEG_SPOP_SBC_1	1357:1361	Mutation rewiring degron network	0.25
p.S1549F	TCGA-Q1-A73O	CESC	TCGA	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation altering degron motif	0.7982
p.T2239M	TCGA-QF-A5YS	UCEC	TCGA	AMTSS	DEG_SPOP_SBC_1	2237:2241	Mutation altering degron motif	0.7423
p.G1364A	DO51939	BLCA	ICGC	PATSS	DEG_SPOP_SBC_1	1357:1361	Mutation rewiring degron network	0.25
p.H1127D	DO51914	BLCA	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation rewiring degron network	0.25
p.E642Q	DO49760	BLCA	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	628:637	Mutation rewiring degron network	0.1944
p.K1124N	DO219087	BLCA	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation altering degron motif	0.6918
p.L1030F	DO219059	BLCA	ICGC	APTTS	DEG_SPOP_SBC_1	1026:1030	Mutation altering degron motif	0.6981
p.I151M	DO474	BLCA	ICGC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1944
p.I1017V	DO225099	BRCA	ICGC	APTTS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.0833
p.S1086C	DO225328	BRCA	ICGC	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation altering degron motif	0.7541
p.L730F	DO228483	BRCA	ICGC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.2222
p.L730F	DO229010	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.2222
p.L730F	DO229016	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.2222
p.L730F	DO229480	LAML	ICGC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.2222
p.L730F	DO230659	LAML	ICGC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.2222
p.L730F	DO52238	LIHC	ICGC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.2222
p.L730F	DO230929	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.2222
p.E1471D	DO1285	BRCA	ICGC	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation rewiring degron network	0.0833
p.L1379V	DO3970	BRCA	ICGC	VATST	DEG_SPOP_SBC_1	1386:1390	Mutation rewiring degron network	0.1389
p.S1084L	DO5936	BRCA	ICGC	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation rewiring degron network	0.2778
p.R59H	DO5521	BRCA	ICGC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.P857S	DO219647	BRCA	ICGC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.1944
p.T1506A	DO222563	BTCA	ICGC	VSTTT	DEG_SPOP_SBC_1	1492:1496	Mutation rewiring degron network	0.0556
p.F1551L	DO49976	CESC	ICGC	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.3056
p.A70V	DO6568	CLLE	ICGC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation altering degron motif	0.5825
p.A947T	DO49095	COAD	ICGC	PPQY	ITCH	951:954	Mutation rewiring degron network	0.2222
p.T1089A	DO227745	COCA	ICGC	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation altering degron motif	0.7139
p.A152T	DO222874	COCA	ICGC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.2222
p.P1109H	DO222874	COCA	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation rewiring degron network	0.1389
p.E1369K	DO222842	COCA	ICGC	PATSS	DEG_SPOP_SBC_1	1357:1361	Mutation rewiring degron network	0.1111
p.C1099S	DO229010	COCA	ICGC	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation substituting flanking lysine	0.1944
p.C1099S	DO229013	COCA	ICGC	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation substituting flanking lysine	0.1944
p.C1099S	DO229016	COCA	ICGC	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation substituting flanking lysine	0.1944
p.C1099S	DO229003	COCA	ICGC	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation substituting flanking lysine	0.1944
p.C1099S	DO229005	COCA	ICGC	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation substituting flanking lysine	0.1944
p.T649P	DO229010	COCA	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	656:662	Mutation rewiring degron network	0.1389
p.T649P	DO229013	COCA	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	656:662	Mutation rewiring degron network	0.1389
p.T649P	DO229016	COCA	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	656:662	Mutation rewiring degron network	0.1389
p.T649P	DO229003	COCA	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	656:662	Mutation rewiring degron network	0.1389
p.T649P	DO229005	COCA	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	656:662	Mutation rewiring degron network	0.1389
p.T649P	DO228947	LICA	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	656:662	Mutation rewiring degron network	0.1389
p.T649P	DO231212	LUSC	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	656:662	Mutation rewiring degron network	0.1389
p.R1550H	DO229003	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation altering degron motif	0.8244
p.R1550H	DO47915	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation altering degron motif	0.8244
p.G722R	DO234232	ESAD	ICGC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation altering degron motif	0.7568
p.R716H	DO223038	ESCA	ICGC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.1667
p.T1889A	DO228494	GACA	ICGC	VLSSS	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.1944
p.G67E	DO11854	GBM	ICGC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.2778
p.G1743A	DO11567	GBM	ICGC	VSTPVST	DEG_SCF_FBW7_1	1734:1740	Mutation rewiring degron network	0.25
p.G1743A	DO11567	GBM	ICGC	PVSTT	DEG_SPOP_SBC_1	1737:1741	Mutation rewiring degron network	0.2778
p.P654L	DO14606	HNSC	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	656:662	Mutation rewiring degron network	0.2778
p.G1132A	DO14284	HNSC	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation rewiring degron network	0.1111
p.A1352S	DO17829	KIRC	ICGC	PATSS	DEG_SPOP_SBC_1	1357:1361	Mutation rewiring degron network	0.1944
p.R59C	DO20766	KIRP	ICGC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.R59C	DO219776	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.R59C	DO43186	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.R59C	DO41331	UCEC	ICGC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.R59C	CHSA0011	bone	COSMIC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.F1099Y	DO20905	KIRP	ICGC	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation substituting flanking lysine	0.1944
p.Q637H	DO228952	LICA	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	628:637	Mutation altering degron motif	0.7582
p.V718F	DO228971	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.2222
p.S1491I	DO228986	LICA	ICGC	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation rewiring degron network	0.1389
p.S1491I	DO228986	LICA	ICGC	VSTTT	DEG_SPOP_SBC_1	1492:1496	Mutation rewiring degron network	0.3056
p.A83S	DO228986	LICA	ICGC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.V724F	DO228986	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation altering degron motif	0.7068
p.M1888I	DO229018	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.1667
p.A639S	DO229019	LICA	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	628:637	Mutation rewiring degron network	0.2778
p.A641S	DO229019	LICA	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	628:637	Mutation rewiring degron network	0.2222
p.G975V	DO229019	LICA	ICGC	IAPSSNVASVCI	DEG_ODPH_VHL_1	960:971	Mutation rewiring degron network	0.2222
p.R715L	DO229029	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.1389
p.C1885F	DO229029	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.0833
p.V78L	DO229028	LICA	ICGC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1944
p.A951S	DO229022	LICA	ICGC	PPQY	ITCH	951:954	Mutation altering degron motif	0.7588
p.G1436V	DO229026	LICA	ICGC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation altering degron motif	0.7532
p.G1364C	DO229026	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	1357:1361	Mutation rewiring degron network	0.25
p.V843F	DO229031	LICA	ICGC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.2778
p.R850L	DO229036	LICA	ICGC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation altering degron motif	0.8428
p.A67S	DO229035	LICA	ICGC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.2778
p.Q611H	DO229041	LICA	ICGC	ASTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1944
p.R714S	DO23176	LINC	ICGC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.1111
p.R714S	DO232224	PBCA	ICGC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.1111
p.M720L	DO50814	LIRI	ICGC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.2778
p.R59L	DO23907	LUAD	ICGC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.L1088V	DO45317	LUAD	ICGC	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation altering degron motif	0.6765
p.L1741F	DO23986	LUAD	ICGC	PVSTT	DEG_SPOP_SBC_1	1737:1741	Mutation altering degron motif	0.6981
p.S1368N	DO52365	LUSC	ICGC	PATSS	DEG_SPOP_SBC_1	1357:1361	Mutation rewiring degron network	0.1389
p.S846F	DO26918	LUSC	ICGC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation altering degron motif	0.7982
p.S1037N	DO26890	LUSC	ICGC	APTTS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.1389
p.E1494D	DO26518	LUSC	ICGC	VSTTT	DEG_SPOP_SBC_1	1492:1496	Mutation altering degron motif	0.6758
p.E858K	DO26469	LUSC	ICGC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.1667
p.A148S	DO27302	LUSC	ICGC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1111
p.A658T	DO27011	LUSC	ICGC	DSGQGSS	DEG_SCF_TRCP1_1	656:662	Mutation altering degron motif	0.7139
p.R79Q	DO228326	MALY	ICGC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1667
p.R66S	DO228338	MALY	ICGC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.25
p.R66S	SIDM00948	Burkitt's Lymphoma	GDSC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.25
p.R66S	ACH-002232	Lymphoma	CCLE	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.25
p.R66S	DG-75	haematopoietic and lymphoid tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.25
p.P836S	DO220877	MELA	ICGC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.0833
p.P1022S	DO220877	MELA	ICGC	APTTS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.2222
p.S1107C	DO27945	ORCA	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation rewiring degron network	0.0833
p.K1559E	DO32636	OV	ICGC	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.0833
p.A944V	DO30830	OV	ICGC	PPQY	ITCH	951:954	Mutation rewiring degron network	0.1389
p.A1545S	DO228138	PBCA	ICGC	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.3056
p.P731H	DO232761	PBCA	ICGC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.1944
p.S1899F	DO232761	PBCA	ICGC	VLSSS	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.3056
p.S1899F	DO231472	THCA	ICGC	VLSSS	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.3056
p.V979I	DO232224	PBCA	ICGC	IAPSSNVASVCI	DEG_ODPH_VHL_1	960:971	Mutation rewiring degron network	0.1111
p.S154W	DO228498	PRAD	ICGC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.2778
p.L1122V	DO51309	PRAD	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation altering degron motif	0.6765
p.Q1432P	DO36556	READ	ICGC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.3056
p.P1362T	DO47168	RECA	ICGC	PATSS	DEG_SPOP_SBC_1	1357:1361	Mutation rewiring degron network	0.3056
p.S1090L	DO37611	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation altering degron motif	0.7667
p.R1550C	DO37802	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation altering degron motif	0.8301
p.P1739H	DO37438	SKCM	ICGC	VSTPVST	DEG_SCF_FBW7_1	1734:1740	Mutation altering degron motif	0.7694
p.P1739H	DO37438	SKCM	ICGC	PVSTT	DEG_SPOP_SBC_1	1737:1741	Mutation altering degron motif	0.7694
p.P1348H	DO47578	SKCM	ICGC	PATSS	DEG_SPOP_SBC_1	1357:1361	Mutation rewiring degron network	0.0833
p.S1475F	DO38871	STAD	ICGC	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation rewiring degron network	0.1944
p.R159W	DO38404	STAD	ICGC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation altering degron motif	0.8634
p.P1502L	DO51795	STAD	ICGC	VSTTT	DEG_SPOP_SBC_1	1492:1496	Mutation rewiring degron network	0.1667
p.P1502L	DO223286	UCEC	ICGC	VSTTT	DEG_SPOP_SBC_1	1492:1496	Mutation rewiring degron network	0.1667
p.T1038A	DO38795	STAD	ICGC	APTTS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.1111
p.R860L	DO47903	STAD	ICGC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.1111
p.T60I	DO229268	THCA	ICGC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation blocking phosphorylation signal	0.5278
p.F72S	DO229272	THCA	ICGC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation altering degron motif	0.7982
p.A152V	DO219773	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.2222
p.L1082I	DO40819	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation rewiring degron network	0.2222
p.S839Y	DO42129	UCEC	ICGC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.1667
p.E1032D	DO43306	UCEC	ICGC	APTTS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.2778
p.A1119T	DO223286	UCEC	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation altering degron motif	0.7139
p.A1119T	DO42673	UCEC	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation altering degron motif	0.7139
p.V1116A	DO43041	UCEC	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation altering degron motif	0.6936
p.S1738N	DO41758	UCEC	ICGC	VSTPVST	DEG_SCF_FBW7_1	1734:1740	Mutation altering degron motif	0.7069
p.S1738N	DO41758	UCEC	ICGC	PVSTT	DEG_SPOP_SBC_1	1737:1741	Mutation altering degron motif	0.7069
p.V1115M	DO52399	UCEC	ICGC	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation blocking phosphorylation signal	0.75
p.A847V	DO41536	UCEC	ICGC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation altering degron motif	0.6936
p.S960P	DO41871	UCEC	ICGC	IAPSSNVASVCI	DEG_ODPH_VHL_1	960:971	Mutation altering degron motif	0.6752
p.R1360W	DO43779	UCEC	ICGC	PATSS	DEG_SPOP_SBC_1	1357:1361	Mutation altering degron motif	0.8634
p.S1728F	DO43755	UCEC	ICGC	LPVTPVVT	DEG_SCF_FBW7_1	1723:1730	Mutation altering degron motif	0.7982
p.Y150C	DO42825	UCEC	ICGC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1667
p.A1022T	SIDM02060	Pancreatic Carcinoma	GDSC	APTTS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.2222
p.R668L	SIDM01958	Esophageal Carcinoma	GDSC	DSGQGSS	DEG_SCF_TRCP1_1	656:662	Mutation rewiring degron network	0.1667
p.I1424M	SIDM00373	Endometrial Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.0833
p.I1424M	SIDM00234	Other Solid Cancers	GDSC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.0833
p.I1424M	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.0833
p.I1424M	SIDM00569	Osteosarcoma	GDSC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.0833
p.I1424M	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.0833
p.I1424M	SIDM00040	Gastric Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.0833
p.I1424M	SIDM00260	Gastric Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.0833
p.I1424M	SIDM00351	Oral Cavity Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.0833
p.I1424M	SIDM00580	Acute Myeloid Leukemia	GDSC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.0833
p.I1424M	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.0833
p.I1424M	SIDM00560	Gastric Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.0833
p.I1424M	SIDM00248	Gastric Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.0833
p.I1424M	SIDM00173	Head and Neck Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.0833
p.I1424M	SIDM01662	Plasma Cell Myeloma	GDSC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.0833
p.I1424M	TMK-1	stomach	COSMIC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.0833
p.I1424M	RERF-LC-KJ	lung	COSMIC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.0833
p.I1424M	SNG-M	endometrium	COSMIC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.0833
p.V1727A	SIDM01016	T-Lymphoblastic Leukemia	GDSC	LPVTPVVT	DEG_SCF_FBW7_1	1723:1730	Mutation altering degron motif	0.6936
p.V1727A	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LPVTPVVT	DEG_SCF_FBW7_1	1723:1730	Mutation altering degron motif	0.6936
p.V1727A	Jurkat	haematopoietic and lymphoid tissue	COSMIC	LPVTPVVT	DEG_SCF_FBW7_1	1723:1730	Mutation altering degron motif	0.6936
p.A149V	SIDM00611	Kidney Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1389
p.A149V	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1389
p.A149V	SIDM00157	Neuroblastoma	GDSC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1389
p.A149V	SIDM00362	Burkitt's Lymphoma	GDSC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1389
p.A149V	SIDM00240	Cervical Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1389
p.A149V	SIDM00192	Colorectal Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1389
p.A149V	SIDM01682	Gastric Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1389
p.A149V	SIDM01377	Ovarian Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1389
p.A149V	SIDM01469	Pancreatic Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1389
p.A149V	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1389
p.A149V	SIDM01316	Ewing's Sarcoma	GDSC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1389
p.A149V	SIDM00164	Biliary Tract Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1389
p.A149V	SIDM00500	Colorectal Carcinoma	GDSC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1389
p.A149V	SIDM01391	Neuroblastoma	GDSC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1389
p.H856R	SIDM00845	Burkitt's Lymphoma	GDSC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.2222
p.H856R	SIDM00461	Acute Myeloid Leukemia	GDSC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.2222
p.H856R	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.2222
p.H856R	SIDM01519	Head and Neck Carcinoma	GDSC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.2222
p.H856R	Daudi	haematopoietic and lymphoid tissue	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.2222
p.H856R	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.2222
p.S977A	SIDM00845	Burkitt's Lymphoma	GDSC	IAPSSNVASVCI	DEG_ODPH_VHL_1	960:971	Mutation rewiring degron network	0.1667
p.S977A	SIDM00461	Acute Myeloid Leukemia	GDSC	IAPSSNVASVCI	DEG_ODPH_VHL_1	960:971	Mutation rewiring degron network	0.1667
p.S977A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	IAPSSNVASVCI	DEG_ODPH_VHL_1	960:971	Mutation rewiring degron network	0.1667
p.S977A	SIDM01519	Head and Neck Carcinoma	GDSC	IAPSSNVASVCI	DEG_ODPH_VHL_1	960:971	Mutation rewiring degron network	0.1667
p.D1431A	SIDM00845	Burkitt's Lymphoma	GDSC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.2778
p.D1431A	SIDM01519	Head and Neck Carcinoma	GDSC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.2778
p.L1475F	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation rewiring degron network	0.1944
p.L1475F	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation rewiring degron network	0.1944
p.V1120L	SIDM00281	Other Solid Cancers	GDSC	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation altering degron motif	0.6765
p.V1120L	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation altering degron motif	0.6765
p.V1120L	SIDM00603	Head and Neck Carcinoma	GDSC	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation altering degron motif	0.6765
p.V1120L	SIDM00164	Biliary Tract Carcinoma	GDSC	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation altering degron motif	0.6765
p.S610N	SIDM00660	Colorectal Carcinoma	GDSC	ASTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1667
p.S610N	LS-411N	large intestine	COSMIC	ASTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1667
p.A1081T	SIDM00660	Colorectal Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation rewiring degron network	0.1944
p.A1081T	LS-411N	large intestine	COSMIC	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation rewiring degron network	0.1944
p.P840H	SIDM00660	Colorectal Carcinoma	GDSC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.1944
p.P840H	ACH-000985	Colon/Colorectal Cancer	CCLE	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.1944
p.P840H	LS-411N	large intestine	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.1944
p.G612S	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	ASTTS	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.2222
p.S1552F	SIDM00284	Melanoma	GDSC	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.2778
p.S1552F	COLO-679	skin	COSMIC	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.2778
p.R82G	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0833
p.R82G	ACH-000603	Lung Cancer	CCLE	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0833
p.R82G	BEN	lung	COSMIC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0833
p.R845C	SIDM00051	Chondrosarcoma	GDSC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation altering degron motif	0.8301
p.R845C	CHSA0011	bone	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation altering degron motif	0.8301
p.S1892F	SIDM01186	Breast Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.2778
p.S1892F	UACC-893	breast	COSMIC	VLSSS	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.2778
p.I841V	SIDM00238	Ovarian Carcinoma	GDSC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.2222
p.I841V	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.2222
p.I841V	OVK-18	ovary	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.2222
p.F946L	SIDM00487	Colorectal Carcinoma	GDSC	PPQY	ITCH	951:954	Mutation rewiring degron network	0.1944
p.F946L	ACH-000963	Colon/Colorectal Cancer	CCLE	PPQY	ITCH	951:954	Mutation rewiring degron network	0.1944
p.F946L	CCK-81	large intestine	COSMIC	PPQY	ITCH	951:954	Mutation rewiring degron network	0.1944
p.H1364Y	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PATSS	DEG_SPOP_SBC_1	1357:1361	Mutation rewiring degron network	0.25
p.H1364Y	NCI-H1155	lung	COSMIC	PATSS	DEG_SPOP_SBC_1	1357:1361	Mutation rewiring degron network	0.25
p.Q855P	SIDM00948	Burkitt's Lymphoma	GDSC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.25
p.Q855P	DG-75	haematopoietic and lymphoid tissue	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.25
p.L640P	SIDM00149	Melanoma	GDSC	EPEEPEADQH	DEG_Kelch_KLHL3_1	628:637	Mutation rewiring degron network	0.25
p.L640P	ACH-000750	Skin Cancer	CCLE	EPEEPEADQH	DEG_Kelch_KLHL3_1	628:637	Mutation rewiring degron network	0.25
p.L640P	LOXIMVI	skin	COSMIC	EPEEPEADQH	DEG_Kelch_KLHL3_1	628:637	Mutation rewiring degron network	0.25
p.K1107R	SIDM00537	Colorectal Carcinoma	GDSC	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation rewiring degron network	0.0833
p.K1107R	GP5d	large intestine	COSMIC	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation rewiring degron network	0.0833
p.I841F	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.2222
p.I841F	NCI-H1435	lung	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.2222
p.R81H	SIDM00951	T-Lymphoblastic Leukemia	GDSC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1111
p.R81H	ACH-002222	Leukemia	CCLE	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1111
p.R81H	CTV-1	haematopoietic and lymphoid tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.1111
p.Q838R	SIDM00901	Endometrial Carcinoma	GDSC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.1389
p.Q838R	ACH-000940	Endometrial/Uterine Cancer	CCLE	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.1389
p.Q838R	AN3-CA	endometrium	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.1389
p.H1548Y	SIDM01503	Small Cell Lung Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation altering degron motif	0.7229
p.V1737L	SIDM01503	Small Cell Lung Carcinoma	GDSC	VSTPVST	DEG_SCF_FBW7_1	1734:1740	Mutation altering degron motif	0.6765
p.V1737L	SIDM01503	Small Cell Lung Carcinoma	GDSC	PVSTT	DEG_SPOP_SBC_1	1737:1741	Mutation altering degron motif	0.6765
p.T1350A	SIDM00165	Other Solid Cancers	GDSC	PATSS	DEG_SPOP_SBC_1	1357:1361	Mutation rewiring degron network	0.1389
p.T1538I	SIDM01617	Endometrial Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.1111
p.S1472Y	SIDM01611	Endometrial Carcinoma	GDSC	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation rewiring degron network	0.1111
p.A1506V	SIDM00500	Colorectal Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	1492:1496	Mutation rewiring degron network	0.0556
p.Q943H	SIDM01451	Pancreatic Carcinoma	GDSC	PPQY	ITCH	951:954	Mutation rewiring degron network	0.1111
p.G956E	ACH-000279	Bone Cancer	CCLE	IAPSSNVASVCI	DEG_ODPH_VHL_1	960:971	Mutation rewiring degron network	0.2222
p.G956E	ACH-000279	Bone Cancer	CCLE	PPQY	ITCH	951:954	Mutation rewiring degron network	0.2778
p.A1541V	ACH-000766	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.1944
p.A1541V	NCI-H1648	lung	COSMIC	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.1944
p.V1485L	ACH-000844	Lung Cancer	CCLE	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation rewiring degron network	0.3056
p.V1485L	ACH-000844	Lung Cancer	CCLE	VSTTT	DEG_SPOP_SBC_1	1492:1496	Mutation rewiring degron network	0.1389
p.M1079I	ACH-000860	Lung Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation rewiring degron network	0.1389
p.M1079I	NCI-H358	lung	COSMIC	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation rewiring degron network	0.1389
p.P1553C	ACH-000873	Esophageal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.25
p.P1553R	ACH-000873	Esophageal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.25
p.P1553R	KYSE-270	oesophagus	COSMIC	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.25
p.V1086A	ACH-000957	Colon/Colorectal Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation altering degron motif	0.5825
p.V1086A	LS-180	large intestine	COSMIC	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation altering degron motif	0.5825
p.P1429L	ACH-000958	Colon/Colorectal Cancer	CCLE	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.2222
p.P1429L	SW48	large intestine	COSMIC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.2222
p.A1722V	ACH-000961	Endometrial/Uterine Cancer	CCLE	LPVTPVVT	DEG_SCF_FBW7_1	1723:1730	Mutation rewiring degron network	0.3056
p.R1117C	ACH-000966	Ovarian Cancer	CCLE	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation altering degron motif	0.8301
p.H1112Y	ACH-000980	Lung Cancer	CCLE	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation rewiring degron network	0.2222
p.H1112Y	NCI-H1155	lung	COSMIC	SRPKLRILN	DEG_APCC_DBOX_1	1116:1124	Mutation rewiring degron network	0.2222
p.A1350T	ACH-000985	Colon/Colorectal Cancer	CCLE	PATSS	DEG_SPOP_SBC_1	1357:1361	Mutation rewiring degron network	0.1389
p.A1350T	LS-411N	large intestine	COSMIC	PATSS	DEG_SPOP_SBC_1	1357:1361	Mutation rewiring degron network	0.1389
p.N2227S	ACH-000986	Colon/Colorectal Cancer	CCLE	AMTSS	DEG_SPOP_SBC_1	2237:2241	Mutation rewiring degron network	0.0556
p.N2227S	HT-115	large intestine	COSMIC	AMTSS	DEG_SPOP_SBC_1	2237:2241	Mutation rewiring degron network	0.0556
p.V1475A	ACH-000995	Leukemia	CCLE	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation rewiring degron network	0.1944
p.V1475A	Jurkat	haematopoietic and lymphoid tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation rewiring degron network	0.1944
p.P153L	ACH-001419	Breast Cancer	CCLE	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.25
p.G1021E	ACH-002023	Colon/Colorectal Cancer	CCLE	APTTS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.1944
p.A1480S	ACH-002800	Unknown	CCLE	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation altering degron motif	0.7588
p.I1432M	TMK-1	stomach	COSMIC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.3056
p.I1432M	RERF-LC-KJ	lung	COSMIC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.3056
p.I1432M	SNG-M	endometrium	COSMIC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.3056
p.P1474Q	SK-OV-3	ovary	COSMIC	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation rewiring degron network	0.1667
p.L83H	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.L83H	Daudi	haematopoietic and lymphoid tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0556
p.P1076T	MFE-319	endometrium	COSMIC	VPSSS	DEG_SPOP_SBC_1	1086:1090	Mutation rewiring degron network	0.0556
p.D966Y	L-540	haematopoietic and lymphoid tissue	COSMIC	IAPSSNVASVCI	DEG_ODPH_VHL_1	960:971	Mutation altering degron motif	0.7325
p.T736A	SNU-61	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.0556
p.H70R	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation altering degron motif	0.8244
p.H70R	Daudi	haematopoietic and lymphoid tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation altering degron motif	0.8244
p.V1499A	LS-180	large intestine	COSMIC	VSTTT	DEG_SPOP_SBC_1	1492:1496	Mutation rewiring degron network	0.25
p.S82N	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0833
p.S82N	Daudi	haematopoietic and lymphoid tissue	COSMIC	AATTT	DEG_SPOP_SBC_1	69:73	Mutation rewiring degron network	0.0833
p.P1490A	SNU-387	liver	COSMIC	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation rewiring degron network	0.1667
p.P1490A	SNU-387	liver	COSMIC	VSTTT	DEG_SPOP_SBC_1	1492:1496	Mutation rewiring degron network	0.2778
p.P1553S	KYSE-270	oesophagus	COSMIC	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.25
p.D1473Y	L-540	haematopoietic and lymphoid tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation rewiring degron network	0.1389
p.L976F	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	IAPSSNVASVCI	DEG_ODPH_VHL_1	960:971	Mutation rewiring degron network	0.1944
p.Q1552E	HCC1395	breast	COSMIC	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.2778
p.S1900F	UACC-893	breast	COSMIC	VLSSS	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.2778
p.R1020L	OE19	oesophagus	COSMIC	APTTS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.1667
p.G854E	REH	haematopoietic and lymphoid tissue	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.2778
p.M1492I	NCI-H358	lung	COSMIC	VSTTT	DEG_SPOP_SBC_1	1492:1496	Mutation altering degron motif	0.7618
p.S1560F	COLO-679	skin	COSMIC	APSSS	DEG_SPOP_SBC_1	1546:1550	Mutation rewiring degron network	0.0556
p.P1737A	SNU-387	liver	COSMIC	VSTPVST	DEG_SCF_FBW7_1	1734:1740	Mutation altering degron motif	0.7503
p.P1737A	SNU-387	liver	COSMIC	PVSTT	DEG_SPOP_SBC_1	1737:1741	Mutation altering degron motif	0.6392
p.G1425V	RL	haematopoietic and lymphoid tissue	COSMIC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.1111
p.L1483F	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation altering degron motif	0.6981
p.K1022R	GP5d	large intestine	COSMIC	APTTS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.2222
p.I1353V	NCI-H1793	lung	COSMIC	PATSS	DEG_SPOP_SBC_1	1357:1361	Mutation rewiring degron network	0.2222
p.S730L	SK-MEL-30	skin	COSMIC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.2222
p.A718T	639-V	urinary tract	COSMIC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.2222
p.L1430V	RKO	large intestine	COSMIC	VPTST	DEG_SPOP_SBC_1	1433:1437	Mutation rewiring degron network	0.25
p.S1713F	COLO-679	skin	COSMIC	LPVTPVVT	DEG_SCF_FBW7_1	1723:1730	Mutation rewiring degron network	0.0556
p.V1888A	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VLSSS	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.1667
p.S1740N	SW48	large intestine	COSMIC	VSTPVST	DEG_SCF_FBW7_1	1734:1740	Mutation altering degron motif	0.7069
p.S1740N	SW48	large intestine	COSMIC	PVSTT	DEG_SPOP_SBC_1	1737:1741	Mutation altering degron motif	0.7069
p.K1896E	AGS	stomach	COSMIC	VLSSS	DEG_SPOP_SBC_1	1894:1898	Mutation altering degron motif	0.7022
p.T1476I	OCI-AML2	haematopoietic and lymphoid tissue	COSMIC	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation rewiring degron network	0.2222
p.D1487Y	SK-MG-1	central nervous system	COSMIC	AGSTT	DEG_SPOP_SBC_1	1480:1484	Mutation rewiring degron network	0.25
p.D1487Y	SK-MG-1	central nervous system	COSMIC	VSTTT	DEG_SPOP_SBC_1	1492:1496	Mutation rewiring degron network	0.1944
p.G153E	REH	haematopoietic and lymphoid tissue	COSMIC	VPSST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.25
p.F1359L	CCK-81	large intestine	COSMIC	PATSS	DEG_SPOP_SBC_1	1357:1361	Mutation altering degron motif	0.6981
p.H719R	KURAMOCHI	ovary	COSMIC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.25
p.V839A	LS-180	large intestine	COSMIC	PISTPHVS	DEG_SCF_FBW7_1	845:852	Mutation rewiring degron network	0.1667
p.P1907L	NCI-H1693	lung	COSMIC	VLSSS	DEG_SPOP_SBC_1	1894:1898	Mutation rewiring degron network	0.0833
p.F734S	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	722:726	Mutation rewiring degron network	0.1111
p.S1393F	UACC-893	breast	COSMIC	VATST	DEG_SPOP_SBC_1	1386:1390	Mutation rewiring degron network	0.25
p.V1735A	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VSTPVST	DEG_SCF_FBW7_1	1734:1740	Mutation altering degron motif	0.6936

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WNK1

UniProt ID: Q9H4A3

Entrez ID: 65125

Protein name: Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WNK1 in