DegronMD

Uniprot ID: Q9H4A3

Source protein: Serine/threonine-protein kinase WNK1

Source gene: WNK1

Class: DEG_SPOP_SBC_1

Location: 1492:1496

E3 ligase: SPOP

DEGRON score: 0.9684

ASA_SCORE: 89.12

COIL: 0.9492

CONS_SCORE: 0.3448

DSS_SCORE: 0.3477

HELIX: 0.013

FCONS_SCORE: 0.9908

RIG_SCORE: 0.7488

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1491L	TCGA-A8-A0A7	BRCA	TCGA	VSTTT	DEG_SPOP_SBC_1	0.3056
p.L1489I	TCGA-B5-A0JU	UCEC	TCGA	VSTTT	DEG_SPOP_SBC_1	0.25
p.S1497L	TCGA-EB-A41B	SKCM	TCGA	VSTTT	DEG_SPOP_SBC_1	0.3056
p.T1506A	DO222563	BTCA	ICGC	VSTTT	DEG_SPOP_SBC_1	0.0556
p.S1491I	DO228986	LICA	ICGC	VSTTT	DEG_SPOP_SBC_1	0.3056
p.E1494D	DO26518	LUSC	ICGC	VSTTT	DEG_SPOP_SBC_1	0.6758
p.P1502L	DO51795	STAD	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1667
p.P1502L	DO223286	UCEC	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1667
p.A1506V	SIDM00500	Colorectal Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	0.0556
p.V1485L	ACH-000844	Lung Cancer	CCLE	VSTTT	DEG_SPOP_SBC_1	0.1389
p.V1499A	LS-180	large_intestine	COSMIC	VSTTT	DEG_SPOP_SBC_1	0.25
p.P1490A	SNU-387	liver	COSMIC	VSTTT	DEG_SPOP_SBC_1	0.2778
p.M1492I	NCI-H358	lung	COSMIC	VSTTT	DEG_SPOP_SBC_1	0.7618
p.D1487Y	SK-MG-1	central_nervous_system	COSMIC	VSTTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	825:829	VSTTT	SPOP	0.8472	More...
O43491	Band 4.1-like protein 2	DEG_SPOP_SBC_1	933:937	VSTTT	SPOP	0.8993	More...
O60216	Double-strand-break repair protein rad21 homolog	DEG_SPOP_SBC_1	184:188	VSTTT	SPOP	0.9908	More...
Q8N0W4	Neuroligin-4, X-linked	DEG_SPOP_SBC_1	607:611	VSTTT	SPOP	0.9168	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	12:16	VSTTT	SPOP	0.9828	More...
Q8NFZ3	Neuroligin-4, Y-linked	DEG_SPOP_SBC_1	607:611	VSTTT	SPOP	0.9392	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	184:188	VSTTT	SPOP	0.9692	More...
Q96E09	PPP2R1A-PPP2R2A-interacting phosphatase regulator 1	DEG_SPOP_SBC_1	261:265	VSTTT	SPOP	0.995	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	848:852	VSTTT	SPOP	0.8971	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1492:1496	VSTTT	SPOP	0.9684	More...
Q9NSB2	Keratin, type II cuticular Hb4	DEG_SPOP_SBC_1	590:594	VSTTT	SPOP	0.6411	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	432:436	VSTTT	SPOP	0.8963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons