DegronMD - Q9NSB2(KRT84)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R588C	TCGA-19-1790	GBM	TCGA	VSTTT	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.2778
p.R588C	DO12328	GBM	ICGC	VSTTT	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.2778
p.R588C	ACH-002360	Non-Cancerous	CCLE	VSTTT	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.2778
p.V566I	TCGA-AD-6899	COAD	TCGA	SEACVPSV	DEG_COP1_1	559:566	Mutation altering degron motif	0.5965
p.V566I	DO8818	COAD	ICGC	SEACVPSV	DEG_COP1_1	559:566	Mutation altering degron motif	0.5965
p.F589L	TCGA-CJ-4638	KIRC	TCGA	VSTTT	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.3056
p.F589L	DO20022	KIRC	ICGC	VSTTT	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.3056
p.G574R	TCGA-D8-A1XQ	BRCA	TCGA	SEACVPSV	DEG_COP1_1	559:566	Mutation rewiring degron network	0.1111
p.G574R	DO3095	BRCA	ICGC	SEACVPSV	DEG_COP1_1	559:566	Mutation rewiring degron network	0.1111
p.R583C	TCGA-DM-A28H	COAD	TCGA	VSTTT	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.1389
p.R583C	DO8906	COAD	ICGC	VSTTT	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.1389
p.G582S	TCGA-DX-A8BJ	SARC	TCGA	VSTTT	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.1111
p.G582S	DO222946	BTCA	ICGC	VSTTT	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.1111
p.G582S	DO220045	SARC	ICGC	VSTTT	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.1111
p.P569S	TCGA-EA-A3HR	CESC	TCGA	SEACVPSV	DEG_COP1_1	559:566	Mutation rewiring degron network	0.25
p.P569S	DO6326	CESC	ICGC	SEACVPSV	DEG_COP1_1	559:566	Mutation rewiring degron network	0.25
p.P569S	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	SEACVPSV	DEG_COP1_1	559:566	Mutation rewiring degron network	0.25
p.R583H	TCGA-EI-6507	READ	TCGA	VSTTT	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.1389
p.R583H	DO36675	READ	ICGC	VSTTT	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.1389
p.R583H	ACH-000940	Endometrial/Uterine Cancer	CCLE	VSTTT	DEG_SPOP_SBC_1	590:594	Mutation rewiring degron network	0.1389
p.E560K	DO220906	MELA	ICGC	SEACVPSV	DEG_COP1_1	559:566	Mutation altering degron motif	0.7022
p.E560K	SIDM00828	Other Sarcomas	GDSC	SEACVPSV	DEG_COP1_1	559:566	Mutation altering degron motif	0.7022
p.E560K	HT-1080	soft tissue	COSMIC	SEACVPSV	DEG_COP1_1	559:566	Mutation altering degron motif	0.7022
p.L557I	SIDM02017	Colorectal Carcinoma	GDSC	SEACVPSV	DEG_COP1_1	559:566	Mutation rewiring degron network	0.2778
p.V563D	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	SEACVPSV	DEG_COP1_1	559:566	Mutation altering degron motif	0.7785
p.V563D	SIDM00044	Head and Neck Carcinoma	GDSC	SEACVPSV	DEG_COP1_1	559:566	Mutation altering degron motif	0.7785
p.V563D	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	SEACVPSV	DEG_COP1_1	559:566	Mutation altering degron motif	0.7785
p.G575D	SIDM00604	Oral Cavity Carcinoma	GDSC	SEACVPSV	DEG_COP1_1	559:566	Mutation rewiring degron network	0.0833
p.G575D	ACH-001542	Head and Neck Cancer	CCLE	SEACVPSV	DEG_COP1_1	559:566	Mutation rewiring degron network	0.0833

Kaplan plot for KRT84 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRT84

UniProt ID: Q9NSB2

Entrez ID: 3890

Protein name: Keratin, type II cuticular Hb4 (Keratin-84) (K84) (Type II hair keratin Hb4) (Type-II keratin Kb24)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRT84 in