DegronMD

Uniprot ID: Q9NSB2

Source protein: Keratin, type II cuticular Hb4

Source gene: KRT84

Class: DEG_COP1_1

Location: 559:566

E3 ligase: COP1

DEGRON score: 0.9601

ASA_SCORE: 77.4375

COIL: 0.7986

CONS_SCORE: 0.8111

DSS_SCORE: 0.2988

HELIX: 0.1241

FCONS_SCORE: 0.9928

RIG_SCORE: 0.7815

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V566I	TCGA-AD-6899	COAD	TCGA	SEACVPSV	DEG_COP1_1	0.5965
p.V566I	DO8818	COAD	ICGC	SEACVPSV	DEG_COP1_1	0.5965
p.G574R	TCGA-D8-A1XQ	BRCA	TCGA	SEACVPSV	DEG_COP1_1	0.1111
p.G574R	DO3095	BRCA	ICGC	SEACVPSV	DEG_COP1_1	0.1111
p.P569S	TCGA-EA-A3HR	CESC	TCGA	SEACVPSV	DEG_COP1_1	0.25
p.P569S	DO6326	CESC	ICGC	SEACVPSV	DEG_COP1_1	0.25
p.P569S	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	SEACVPSV	DEG_COP1_1	0.25
p.E560K	DO220906	MELA	ICGC	SEACVPSV	DEG_COP1_1	0.7022
p.E560K	SIDM00828	Other Sarcomas	GDSC	SEACVPSV	DEG_COP1_1	0.7022
p.E560K	HT-1080	soft_tissue	COSMIC	SEACVPSV	DEG_COP1_1	0.7022
p.L557I	SIDM02017	Colorectal Carcinoma	GDSC	SEACVPSV	DEG_COP1_1	0.2778
p.V563D	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	SEACVPSV	DEG_COP1_1	0.7785
p.V563D	SIDM00044	Head and Neck Carcinoma	GDSC	SEACVPSV	DEG_COP1_1	0.7785
p.V563D	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	SEACVPSV	DEG_COP1_1	0.7785
p.G575D	SIDM00604	Oral Cavity Carcinoma	GDSC	SEACVPSV	DEG_COP1_1	0.0833
p.G575D	ACH-001542	Head and Neck Cancer	CCLE	SEACVPSV	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NSB2	Keratin, type II cuticular Hb4	DEG_COP1_1	559:566	SEACVPSV	COP1	0.9601	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons