DegronMD

Uniprot ID: Q9NSB2

Source protein: Keratin, type II cuticular Hb4

Source gene: KRT84

Class: DEG_SPOP_SBC_1

Location: 590:594

E3 ligase: SPOP

DEGRON score: 0.6411

ASA_SCORE: 67.64

COIL: 0.6354

CONS_SCORE: 0.787

DSS_SCORE: 0.4392

HELIX: 0.0104

FCONS_SCORE: 0.973

RIG_SCORE: 0.77

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R588C	TCGA-19-1790	GBM	TCGA	VSTTT	DEG_SPOP_SBC_1	0.2778
p.R588C	DO12328	GBM	ICGC	VSTTT	DEG_SPOP_SBC_1	0.2778
p.R588C	ACH-002360	Non-Cancerous	CCLE	VSTTT	DEG_SPOP_SBC_1	0.2778
p.F589L	TCGA-CJ-4638	KIRC	TCGA	VSTTT	DEG_SPOP_SBC_1	0.3056
p.F589L	DO20022	KIRC	ICGC	VSTTT	DEG_SPOP_SBC_1	0.3056
p.R583C	TCGA-DM-A28H	COAD	TCGA	VSTTT	DEG_SPOP_SBC_1	0.1389
p.R583C	DO8906	COAD	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1389
p.G582S	TCGA-DX-A8BJ	SARC	TCGA	VSTTT	DEG_SPOP_SBC_1	0.1111
p.G582S	DO222946	BTCA	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1111
p.G582S	DO220045	SARC	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1111
p.R583H	TCGA-EI-6507	READ	TCGA	VSTTT	DEG_SPOP_SBC_1	0.1389
p.R583H	DO36675	READ	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1389
p.R583H	ACH-000940	Endometrial/Uterine Cancer	CCLE	VSTTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	825:829	VSTTT	SPOP	0.8472	More...
O43491	Band 4.1-like protein 2	DEG_SPOP_SBC_1	933:937	VSTTT	SPOP	0.8993	More...
O60216	Double-strand-break repair protein rad21 homolog	DEG_SPOP_SBC_1	184:188	VSTTT	SPOP	0.9908	More...
Q8N0W4	Neuroligin-4, X-linked	DEG_SPOP_SBC_1	607:611	VSTTT	SPOP	0.9168	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	12:16	VSTTT	SPOP	0.9828	More...
Q8NFZ3	Neuroligin-4, Y-linked	DEG_SPOP_SBC_1	607:611	VSTTT	SPOP	0.9392	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	184:188	VSTTT	SPOP	0.9692	More...
Q96E09	PPP2R1A-PPP2R2A-interacting phosphatase regulator 1	DEG_SPOP_SBC_1	261:265	VSTTT	SPOP	0.995	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	848:852	VSTTT	SPOP	0.8971	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1492:1496	VSTTT	SPOP	0.9684	More...
Q9NSB2	Keratin, type II cuticular Hb4	DEG_SPOP_SBC_1	590:594	VSTTT	SPOP	0.6411	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	432:436	VSTTT	SPOP	0.8963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons