DegronMD - Q8N0W4(NLGN4X)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V607I	TCGA-33-AAS8	LUSC	TCGA	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation altering degron motif	0.7076
p.V607I	DO219123	LUSC	ICGC	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation altering degron motif	0.7076
p.R765C	TCGA-36-2539	OV	TCGA	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1944
p.R765C	DO233900	GACA	ICGC	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1944
p.R765C	SIDM00999	Bladder Carcinoma	GDSC	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1944
p.R765C	ACH-000973	Bladder Cancer	CCLE	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1944
p.R765C	639-V	urinary tract	COSMIC	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1944
p.L600F	TCGA-50-5930	LUAD	TCGA	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1389
p.L600F	DO25189	LUAD	ICGC	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1389
p.P616Q	TCGA-69-7974	LUAD	TCGA	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1944
p.P616Q	DO23850	LUAD	ICGC	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1944
p.T763M	TCGA-AA-3492	COAD	TCGA	PPDY	ITCH	757:760	Mutation rewiring degron network	0.25
p.T763M	DO8224	COAD	ICGC	PPDY	ITCH	757:760	Mutation rewiring degron network	0.25
p.T763M	DO222874	COCA	ICGC	PPDY	ITCH	757:760	Mutation rewiring degron network	0.25
p.S767L	TCGA-AN-A0FX	BRCA	TCGA	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1389
p.S767L	DO1449	BRCA	ICGC	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1389
p.S767L	DO51469	PACA	ICGC	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1389
p.D750N	TCGA-AP-A1DV	UCEC	TCGA	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1389
p.D750N	DO43186	UCEC	ICGC	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1389
p.D750N	SIDM01617	Endometrial Carcinoma	GDSC	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1389
p.D750N	ACH-000994	Endometrial/Uterine Cancer	CCLE	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1389
p.R765H	TCGA-C5-A1BI	CESC	TCGA	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1944
p.R765H	TCGA-DM-A28E	COAD	TCGA	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1944
p.R765H	DO44305	CESC	ICGC	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1944
p.R765H	DO7906	COAD	ICGC	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1944
p.R765H	DO233620	GACA	ICGC	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1944
p.R765H	ACH-001460	Colon/Colorectal Cancer	CCLE	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1944
p.E602K	TCGA-D3-A2JG	SKCM	TCGA	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1944
p.E602K	DO233206	GACA	ICGC	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1944
p.E602K	DO44828	LICA	ICGC	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1944
p.E602K	DO47613	SKCM	ICGC	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1944
p.S608L	TCGA-D3-A8GQ	SKCM	TCGA	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation altering degron motif	0.6556
p.S608L	DO51246	SKCM	ICGC	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation altering degron motif	0.6556
p.P757Q	TCGA-E9-A295	BRCA	TCGA	PPDY	ITCH	757:760	Mutation altering degron motif	0.7035
p.P757Q	DO3703	BRCA	ICGC	PPDY	ITCH	757:760	Mutation altering degron motif	0.7035
p.P614S	TCGA-EE-A182	SKCM	TCGA	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.25
p.P614S	DO37814	SKCM	ICGC	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.25
p.P757L	TCGA-EE-A3AA	SKCM	TCGA	PPDY	ITCH	757:760	Mutation altering degron motif	0.7582
p.P757L	DO222632	MELA	ICGC	PPDY	ITCH	757:760	Mutation altering degron motif	0.7582
p.P757L	DO37571	SKCM	ICGC	PPDY	ITCH	757:760	Mutation altering degron motif	0.7582
p.S767P	TCGA-F4-6570	COAD	TCGA	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1389
p.S767P	DO10443	COAD	ICGC	PPDY	ITCH	757:760	Mutation rewiring degron network	0.1389
p.P758Q	TCGA-FS-A1ZG	SKCM	TCGA	PPDY	ITCH	757:760	Mutation altering degron motif	0.7035
p.P758Q	DO229022	LICA	ICGC	PPDY	ITCH	757:760	Mutation altering degron motif	0.7035
p.P758Q	DO37523	SKCM	ICGC	PPDY	ITCH	757:760	Mutation altering degron motif	0.7035
p.I603V	TCGA-HU-8604	STAD	TCGA	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.2222
p.I603V	DO47907	STAD	ICGC	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.2222
p.D617A	TCGA-UZ-A9PN	KIRP	TCGA	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1667
p.D617A	DO219703	KIRP	ICGC	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1667
p.M618I	TCGA-Z2-A8RT	SKCM	TCGA	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1389
p.M618I	DO51301	SKCM	ICGC	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1389
p.D759E	DO228974	LICA	ICGC	PPDY	ITCH	757:760	Mutation altering degron motif	0.5647
p.Q747K	DO228978	LICA	ICGC	PPDY	ITCH	757:760	Mutation rewiring degron network	0.0556
p.Y760C	DO231710	LINC	ICGC	PPDY	ITCH	757:760	Mutation altering degron motif	0.8198
p.P616S	DO45277	LIRI	ICGC	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1944
p.P614H	SIDM00216	Colorectal Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.25
p.P614H	ACH-000989	Colon/Colorectal Cancer	CCLE	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.25
p.P614H	SNU-175	large intestine	COSMIC	VSTTT	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.25
p.R753S	SIDM01077	Prostate Carcinoma	GDSC	PPDY	ITCH	757:760	Mutation rewiring degron network	0.2222
p.R753S	ACH-000115	Prostate Cancer	CCLE	PPDY	ITCH	757:760	Mutation rewiring degron network	0.2222
p.R753S	VCaP	prostate	COSMIC	PPDY	ITCH	757:760	Mutation rewiring degron network	0.2222
p.T761S	SIDM01750	Melanoma	GDSC	PPDY	ITCH	757:760	Mutation rewiring degron network	0.3056
p.T761S	ACH-000801	Skin Cancer	CCLE	PPDY	ITCH	757:760	Mutation rewiring degron network	0.3056
p.P757T	ACH-000820	Colon/Colorectal Cancer	CCLE	PPDY	ITCH	757:760	Mutation altering degron motif	0.7031

Kaplan plot for NLGN4X in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NLGN4X

UniProt ID: Q8N0W4

Entrez ID: 57502

Protein name: Neuroligin-4, X-linked (Neuroligin X) (HNLX)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NLGN4X in