DegronMD

Uniprot ID: Q8N0W4

Source protein: Neuroligin-4, X-linked

Source gene: NLGN4X

Class: DEG_SPOP_SBC_1

Location: 607:611

E3 ligase: SPOP

DEGRON score: 0.9168

ASA_SCORE: 81.02

COIL: 0.8732

CONS_SCORE: 0.2696

DSS_SCORE: 0.3179

HELIX: 0.0704

FCONS_SCORE: 0.9581

RIG_SCORE: 0.7981

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V607I	TCGA-33-AAS8	LUSC	TCGA	VSTTT	DEG_SPOP_SBC_1	0.7076
p.V607I	DO219123	LUSC	ICGC	VSTTT	DEG_SPOP_SBC_1	0.7076
p.L600F	TCGA-50-5930	LUAD	TCGA	VSTTT	DEG_SPOP_SBC_1	0.1389
p.L600F	DO25189	LUAD	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1389
p.P616Q	TCGA-69-7974	LUAD	TCGA	VSTTT	DEG_SPOP_SBC_1	0.1944
p.P616Q	DO23850	LUAD	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1944
p.E602K	TCGA-D3-A2JG	SKCM	TCGA	VSTTT	DEG_SPOP_SBC_1	0.1944
p.E602K	DO233206	GACA	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1944
p.E602K	DO44828	LICA	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1944
p.E602K	DO47613	SKCM	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1944
p.S608L	TCGA-D3-A8GQ	SKCM	TCGA	VSTTT	DEG_SPOP_SBC_1	0.6556
p.S608L	DO51246	SKCM	ICGC	VSTTT	DEG_SPOP_SBC_1	0.6556
p.P614S	TCGA-EE-A182	SKCM	TCGA	VSTTT	DEG_SPOP_SBC_1	0.25
p.P614S	DO37814	SKCM	ICGC	VSTTT	DEG_SPOP_SBC_1	0.25
p.I603V	TCGA-HU-8604	STAD	TCGA	VSTTT	DEG_SPOP_SBC_1	0.2222
p.I603V	DO47907	STAD	ICGC	VSTTT	DEG_SPOP_SBC_1	0.2222
p.D617A	TCGA-UZ-A9PN	KIRP	TCGA	VSTTT	DEG_SPOP_SBC_1	0.1667
p.D617A	DO219703	KIRP	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1667
p.M618I	TCGA-Z2-A8RT	SKCM	TCGA	VSTTT	DEG_SPOP_SBC_1	0.1389
p.M618I	DO51301	SKCM	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1389
p.P616S	DO45277	LIRI	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1944
p.P614H	SIDM00216	Colorectal Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	0.25
p.P614H	ACH-000989	Colon/Colorectal Cancer	CCLE	VSTTT	DEG_SPOP_SBC_1	0.25
p.P614H	SNU-175	large_intestine	COSMIC	VSTTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	825:829	VSTTT	SPOP	0.8472	More...
O43491	Band 4.1-like protein 2	DEG_SPOP_SBC_1	933:937	VSTTT	SPOP	0.8993	More...
O60216	Double-strand-break repair protein rad21 homolog	DEG_SPOP_SBC_1	184:188	VSTTT	SPOP	0.9908	More...
Q8N0W4	Neuroligin-4, X-linked	DEG_SPOP_SBC_1	607:611	VSTTT	SPOP	0.9168	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	12:16	VSTTT	SPOP	0.9828	More...
Q8NFZ3	Neuroligin-4, Y-linked	DEG_SPOP_SBC_1	607:611	VSTTT	SPOP	0.9392	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	184:188	VSTTT	SPOP	0.9692	More...
Q96E09	PPP2R1A-PPP2R2A-interacting phosphatase regulator 1	DEG_SPOP_SBC_1	261:265	VSTTT	SPOP	0.995	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	848:852	VSTTT	SPOP	0.8971	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1492:1496	VSTTT	SPOP	0.9684	More...
Q9NSB2	Keratin, type II cuticular Hb4	DEG_SPOP_SBC_1	590:594	VSTTT	SPOP	0.6411	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	432:436	VSTTT	SPOP	0.8963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons