DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VSTTT
Uniprot ID:
A6NF01
Source protein:
Putative nuclear envelope pore membrane protein POM 121B
Source gene:
POM121B
Class:
DEG_SPOP_SBC_1
Location:
432:436
E3 ligase:
SPOP
DEGRON score:
0.8963
ASA_SCORE:
89.88
COIL:
0.9522
CONS_SCORE:
0.2167
DSS_SCORE:
0.3305
HELIX:
0.0174
FCONS_SCORE:
0.6706
RIG_SCORE:
0.6818
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with POM121B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VSTTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A8CG34
Nuclear envelope pore membrane protein POM 121C
DEG_SPOP_SBC_1
825:829
VSTTT
SPOP
0.8472
More...
O43491
Band 4.1-like protein 2
DEG_SPOP_SBC_1
933:937
VSTTT
SPOP
0.8993
More...
O60216
Double-strand-break repair protein rad21 homolog
DEG_SPOP_SBC_1
184:188
VSTTT
SPOP
0.9908
More...
Q8N0W4
Neuroligin-4, X-linked
DEG_SPOP_SBC_1
607:611
VSTTT
SPOP
0.9168
More...
Q8NDX5
Polyhomeotic-like protein 3
DEG_SPOP_SBC_1
12:16
VSTTT
SPOP
0.9828
More...
Q8NFZ3
Neuroligin-4, Y-linked
DEG_SPOP_SBC_1
607:611
VSTTT
SPOP
0.9392
More...
Q96D42
Hepatitis A virus cellular receptor 1
DEG_SPOP_SBC_1
184:188
VSTTT
SPOP
0.9692
More...
Q96E09
PPP2R1A-PPP2R2A-interacting phosphatase regulator 1
DEG_SPOP_SBC_1
261:265
VSTTT
SPOP
0.995
More...
Q96HA1
Nuclear envelope pore membrane protein POM 121
DEG_SPOP_SBC_1
848:852
VSTTT
SPOP
0.8971
More...
Q9H4A3
Serine/threonine-protein kinase WNK1
DEG_SPOP_SBC_1
1492:1496
VSTTT
SPOP
0.9684
More...
Q9NSB2
Keratin, type II cuticular Hb4
DEG_SPOP_SBC_1
590:594
VSTTT
SPOP
0.6411
More...
A6NF01
Putative nuclear envelope pore membrane protein POM 121B
DEG_SPOP_SBC_1
432:436
VSTTT
SPOP
0.8963
More...