DegronMD

Uniprot ID: Q96D42

Source protein: Hepatitis A virus cellular receptor 1

Source gene: HAVCR1

Class: DEG_SPOP_SBC_1

Location: 184:188

E3 ligase: SPOP

DEGRON score: 0.9692

ASA_SCORE: 93.5

COIL: 0.9292

CONS_SCORE: 0.3378

DSS_SCORE: 0.4288

HELIX: 0.0168

FCONS_SCORE: 1.1268

RIG_SCORE: 0.8034

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S189I	TCGA-BS-A0UF	UCEC	TCGA	VSTTT	DEG_SPOP_SBC_1	0.3056
p.S189I	DO41488	UCEC	ICGC	VSTTT	DEG_SPOP_SBC_1	0.3056
p.T188M	TCGA-EO-A22U	UCEC	TCGA	VSTTT	DEG_SPOP_SBC_1	0.7423
p.T188M	TCGA-OR-A5LM	ACC	TCGA	VSTTT	DEG_SPOP_SBC_1	0.7423
p.T188M	DO50406	ESAD	ICGC	VSTTT	DEG_SPOP_SBC_1	0.7423
p.T188M	DO43755	UCEC	ICGC	VSTTT	DEG_SPOP_SBC_1	0.7423
p.M182I	TCGA-EO-A22U	UCEC	TCGA	VSTTT	DEG_SPOP_SBC_1	0.2778
p.M182I	TCGA-UT-A88C	MESO	TCGA	VSTTT	DEG_SPOP_SBC_1	0.2778
p.M182I	DO43755	UCEC	ICGC	VSTTT	DEG_SPOP_SBC_1	0.2778
p.T177A	TCGA-F1-A448	STAD	TCGA	VSTTT	DEG_SPOP_SBC_1	0.1389
p.T177A	DO48044	STAD	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1389
p.L179P	DO229010	COCA	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1944
p.L179P	DO229013	COCA	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1944
p.L179P	DO229016	COCA	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1944
p.L179P	DO229003	COCA	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1944
p.L179P	DO229005	COCA	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1944
p.S195R	DO223007	ESCA	ICGC	VSTTT	DEG_SPOP_SBC_1	0.1389
p.T174M	DO222549	ESCA	ICGC	VSTTT	DEG_SPOP_SBC_1	0.0556
p.T174M	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	0.0556
p.T174M	SIDM00210	Ovarian Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	0.0556
p.T174M	SIDM01112	Osteosarcoma	GDSC	VSTTT	DEG_SPOP_SBC_1	0.0556
p.T174M	SIDM00068	Colorectal Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	0.0556
p.T174M	SIDM00257	Neuroblastoma	GDSC	VSTTT	DEG_SPOP_SBC_1	0.0556
p.T186M	DO222618	ESCA	ICGC	VSTTT	DEG_SPOP_SBC_1	0.7423
p.T186M	SIDM00633	Breast Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	0.7423
p.T186M	SIDM00690	Head and Neck Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	0.7423
p.T186M	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	0.7423
p.T186M	SIDM00849	Kidney Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	0.7423
p.T186M	SIDM00875	Breast Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	0.7423
p.T186M	SIDM00930	Osteosarcoma	GDSC	VSTTT	DEG_SPOP_SBC_1	0.7423
p.T186M	SIDM00954	Breast Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	0.7423
p.T186M	SIDM00808	Burkitt's Lymphoma	GDSC	VSTTT	DEG_SPOP_SBC_1	0.7423
p.T186M	SIDM01173	Rhabdomyosarcoma	GDSC	VSTTT	DEG_SPOP_SBC_1	0.7423
p.T186M	SIDM01409	Bladder Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	0.7423
p.T186M	SIDM01254	Burkitt's Lymphoma	GDSC	VSTTT	DEG_SPOP_SBC_1	0.7423
p.T181K	DO228976	LICA	ICGC	VSTTT	DEG_SPOP_SBC_1	0.25
p.T180K	DO229038	LICA	ICGC	VSTTT	DEG_SPOP_SBC_1	0.2222
p.T176M	SIDM00429	B-Lymphoblastic Leukemia	GDSC	VSTTT	DEG_SPOP_SBC_1	0.1111
p.T176M	ACH-000938	Leukemia	CCLE	VSTTT	DEG_SPOP_SBC_1	0.1111
p.T176M	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	VSTTT	DEG_SPOP_SBC_1	0.1111
p.T174K	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	VSTTT	DEG_SPOP_SBC_1	0.0556
p.T174K	UACC-893	breast	COSMIC	VSTTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	825:829	VSTTT	SPOP	0.8472	More...
O43491	Band 4.1-like protein 2	DEG_SPOP_SBC_1	933:937	VSTTT	SPOP	0.8993	More...
O60216	Double-strand-break repair protein rad21 homolog	DEG_SPOP_SBC_1	184:188	VSTTT	SPOP	0.9908	More...
Q8N0W4	Neuroligin-4, X-linked	DEG_SPOP_SBC_1	607:611	VSTTT	SPOP	0.9168	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	12:16	VSTTT	SPOP	0.9828	More...
Q8NFZ3	Neuroligin-4, Y-linked	DEG_SPOP_SBC_1	607:611	VSTTT	SPOP	0.9392	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	184:188	VSTTT	SPOP	0.9692	More...
Q96E09	PPP2R1A-PPP2R2A-interacting phosphatase regulator 1	DEG_SPOP_SBC_1	261:265	VSTTT	SPOP	0.995	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	848:852	VSTTT	SPOP	0.8971	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1492:1496	VSTTT	SPOP	0.9684	More...
Q9NSB2	Keratin, type II cuticular Hb4	DEG_SPOP_SBC_1	590:594	VSTTT	SPOP	0.6411	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	432:436	VSTTT	SPOP	0.8963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSTTT

Degron related mutations and impact score

Drug responses associated with HAVCR1 mutations

All proteins holding degron of VSTTT