DegronMD - O43491(EPB41L2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G916V	TCGA-05-4424	LUAD	TCGA	DSGTLLT	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.2778
p.G916C	TCGA-05-4424	LUAD	TCGA	DSGTLLT	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.2778
p.E779V	TCGA-58-A46J	LUSC	TCGA	EREEAVPEA	DEG_COP1_1	789:797	Mutation rewiring degron network	0.0556
p.K786Q	TCGA-B5-A3FA	UCEC	TCGA	EREEAVPEA	DEG_COP1_1	789:797	Mutation substituting flanking lysine	0.3611
p.P781L	TCGA-DA-A1IA	SKCM	TCGA	EREEAVPEA	DEG_COP1_1	789:797	Mutation rewiring degron network	0.1111
p.E996Q	TCGA-EA-A3HU	CESC	TCGA	VVVHKE	LIG_APCC_ABBA_1	991:996	Mutation altering degron motif	0.6744
p.E996Q	TCGA-EA-A3HU	CESC	TCGA	RVVVHKE	LIG_APCC_ABBAyCdc20_2	990:996	Mutation altering degron motif	0.6744
p.E996Q	DO6320	CESC	ICGC	VVVHKE	LIG_APCC_ABBA_1	991:996	Mutation altering degron motif	0.6744
p.E996Q	DO6320	CESC	ICGC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	990:996	Mutation altering degron motif	0.6744
p.P783L	TCGA-EE-A2GI	SKCM	TCGA	EREEAVPEA	DEG_COP1_1	789:797	Mutation rewiring degron network	0.1667
p.S932F	TCGA-FW-A3R5	SKCM	TCGA	DSGTLLT	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.1111
p.S932F	TCGA-FW-A3R5	SKCM	TCGA	VSTTT	DEG_SPOP_SBC_1	933:937	Mutation rewiring degron network	0.3056
p.S932F	TCGA-GN-A4U3	SKCM	TCGA	DSGTLLT	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.1111
p.S932F	TCGA-GN-A4U3	SKCM	TCGA	VSTTT	DEG_SPOP_SBC_1	933:937	Mutation rewiring degron network	0.3056
p.H994R	TCGA-G3-A5SK	LIHC	TCGA	VVVHKE	LIG_APCC_ABBA_1	991:996	Mutation altering degron motif	0.8244
p.H994R	TCGA-G3-A5SK	LIHC	TCGA	RVVVHKE	LIG_APCC_ABBAyCdc20_2	990:996	Mutation altering degron motif	0.8244
p.H994R	DO45005	LIHC	ICGC	VVVHKE	LIG_APCC_ABBA_1	991:996	Mutation altering degron motif	0.8244
p.H994R	DO45005	LIHC	ICGC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	990:996	Mutation altering degron motif	0.8244
p.S908C	TCGA-GM-A2D9	BRCA	TCGA	DSGTLLT	DEG_SCF_TRCP1_1	918:924	Mutation blocking phosphorylation signal	0.5
p.G804V	TCGA-MN-A4N4	LUAD	TCGA	EREEAVPEA	DEG_COP1_1	789:797	Mutation rewiring degron network	0.1389
p.E1002Q	TCGA-N9-A4Q7	UCS	TCGA	VVVHKE	LIG_APCC_ABBA_1	991:996	Mutation rewiring degron network	0.1667
p.E1002Q	TCGA-N9-A4Q7	UCS	TCGA	RVVVHKE	LIG_APCC_ABBAyCdc20_2	990:996	Mutation rewiring degron network	0.1667
p.S798I	TCGA-VS-A9V1	CESC	TCGA	EREEAVPEA	DEG_COP1_1	789:797	Mutation blocking phosphorylation signal	0.75
p.E996A	DO222500	ESCA	ICGC	VVVHKE	LIG_APCC_ABBA_1	991:996	Mutation altering degron motif	0.7701
p.E996A	DO222500	ESCA	ICGC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	990:996	Mutation altering degron motif	0.7701
p.S987L	DO228946	LICA	ICGC	VVVHKE	LIG_APCC_ABBA_1	991:996	Mutation blocking phosphorylation signal	0.6667
p.S987L	DO228946	LICA	ICGC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	990:996	Mutation blocking phosphorylation signal	0.6944
p.H983N	DO229038	LICA	ICGC	VVVHKE	LIG_APCC_ABBA_1	991:996	Mutation rewiring degron network	0.1111
p.H983N	DO229038	LICA	ICGC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	990:996	Mutation rewiring degron network	0.1389
p.E998Q	DO230993	LUSC	ICGC	VVVHKE	LIG_APCC_ABBA_1	991:996	Mutation rewiring degron network	0.2778
p.E998Q	DO230993	LUSC	ICGC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	990:996	Mutation rewiring degron network	0.2778
p.E998Q	DO230990	LUSC	ICGC	VVVHKE	LIG_APCC_ABBA_1	991:996	Mutation rewiring degron network	0.2778
p.E998Q	DO230990	LUSC	ICGC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	990:996	Mutation rewiring degron network	0.2778
p.E981G	DO230451	UTCA	ICGC	VVVHKE	LIG_APCC_ABBA_1	991:996	Mutation rewiring degron network	0.0556
p.E981G	DO230451	UTCA	ICGC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	990:996	Mutation rewiring degron network	0.0833
p.V933A	SIDM00845	Burkitt's Lymphoma	GDSC	VSTTT	DEG_SPOP_SBC_1	933:937	Mutation altering degron motif	0.5825
p.V933A	SIDM00461	Acute Myeloid Leukemia	GDSC	VSTTT	DEG_SPOP_SBC_1	933:937	Mutation altering degron motif	0.5825
p.V933A	SIDM01519	Head and Neck Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	933:937	Mutation altering degron motif	0.5825
p.T921M	SIDM00845	Burkitt's Lymphoma	GDSC	DSGTLLT	DEG_SCF_TRCP1_1	918:924	Mutation altering degron motif	0.6312
p.T921M	SIDM00032	Bladder Carcinoma	GDSC	DSGTLLT	DEG_SCF_TRCP1_1	918:924	Mutation altering degron motif	0.6312
p.T921M	SIDM01519	Head and Neck Carcinoma	GDSC	DSGTLLT	DEG_SCF_TRCP1_1	918:924	Mutation altering degron motif	0.6312
p.T921A	SIDM00845	Burkitt's Lymphoma	GDSC	DSGTLLT	DEG_SCF_TRCP1_1	918:924	Mutation altering degron motif	0.6028
p.T938N	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	VSTTT	DEG_SPOP_SBC_1	933:937	Mutation rewiring degron network	0.3056
p.T938N	NCI-H2087	lung	COSMIC	VSTTT	DEG_SPOP_SBC_1	933:937	Mutation rewiring degron network	0.3056
p.E1001D	SIDM00976	Melanoma	GDSC	VVVHKE	LIG_APCC_ABBA_1	991:996	Mutation rewiring degron network	0.1944
p.E1001D	SIDM00976	Melanoma	GDSC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	990:996	Mutation rewiring degron network	0.1944
p.E1001D	WM1552C	skin	COSMIC	VVVHKE	LIG_APCC_ABBA_1	991:996	Mutation rewiring degron network	0.1944
p.E1001D	WM1552C	skin	COSMIC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	990:996	Mutation rewiring degron network	0.1944
p.E796K	SIDM01766	Chondrosarcoma	GDSC	EREEAVPEA	DEG_COP1_1	789:797	Mutation altering degron motif	0.7022
p.G781E	ACH-000426	Myeloma	CCLE	EREEAVPEA	DEG_COP1_1	789:797	Mutation rewiring degron network	0.1111
p.E806Q	ACH-001411	Bladder Cancer	CCLE	EREEAVPEA	DEG_COP1_1	789:797	Mutation rewiring degron network	0.0833
p.E931D	ACH-002205	Skin Cancer	CCLE	DSGTLLT	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.1389
p.E931D	ACH-002205	Skin Cancer	CCLE	VSTTT	DEG_SPOP_SBC_1	933:937	Mutation rewiring degron network	0.2778
p.E931D	WM1552C	skin	COSMIC	DSGTLLT	DEG_SCF_TRCP1_1	918:924	Mutation rewiring degron network	0.1389
p.E931D	WM1552C	skin	COSMIC	VSTTT	DEG_SPOP_SBC_1	933:937	Mutation rewiring degron network	0.2778
p.E782K	ACH-002253	Lymphoma	CCLE	EREEAVPEA	DEG_COP1_1	789:797	Mutation rewiring degron network	0.1389
p.E782K	JSC-1	haematopoietic and lymphoid tissue	COSMIC	EREEAVPEA	DEG_COP1_1	789:797	Mutation rewiring degron network	0.1389
p.R804H	NCI-H1048	lung	COSMIC	EREEAVPEA	DEG_COP1_1	789:797	Mutation rewiring degron network	0.1389
p.S784T	MLMA	haematopoietic and lymphoid tissue	COSMIC	EREEAVPEA	DEG_COP1_1	789:797	Mutation rewiring degron network	0.1944
p.P800L	23132-87	stomach	COSMIC	EREEAVPEA	DEG_COP1_1	789:797	Mutation rewiring degron network	0.25
p.E807D	WM1552C	skin	COSMIC	EREEAVPEA	DEG_COP1_1	789:797	Mutation rewiring degron network	0.0556
p.T785N	NCI-H2087	lung	COSMIC	EREEAVPEA	DEG_COP1_1	789:797	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPB41L2

UniProt ID: O43491

Entrez ID: 2037

Protein name: Band 4.1-like protein 2 (Erythrocyte membrane protein band 4.1-like 2) (Generally expressed protein 4.1) (4.1G)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPB41L2 in