DegronMD

Uniprot ID: O43491

Source protein: Band 4.1-like protein 2

Source gene: EPB41L2

Class: LIG_APCC_ABBAyCdc20_2

Location: 990:996

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.988

ASA_SCORE: 79.5857

COIL: 0.1323

CONS_SCORE: 0.5663

DSS_SCORE: 0.5778

HELIX: 0.0104

FCONS_SCORE: 1.2623

RIG_SCORE: 0.7817

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E996Q	TCGA-EA-A3HU	CESC	TCGA	RVVVHKE	LIG_APCC_ABBAyCdc20_2	0.6744
p.E996Q	DO6320	CESC	ICGC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	0.6744
p.H994R	TCGA-G3-A5SK	LIHC	TCGA	RVVVHKE	LIG_APCC_ABBAyCdc20_2	0.8244
p.H994R	DO45005	LIHC	ICGC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	0.8244
p.E1002Q	TCGA-N9-A4Q7	UCS	TCGA	RVVVHKE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E996A	DO222500	ESCA	ICGC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	0.7701
p.S987L	DO228946	LICA	ICGC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	0.6944
p.H983N	DO229038	LICA	ICGC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.E998Q	DO230993	LUSC	ICGC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E998Q	DO230990	LUSC	ICGC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E981G	DO230451	UTCA	ICGC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E1001D	SIDM00976	Melanoma	GDSC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	0.1944
p.E1001D	WM1552C	skin	COSMIC	RVVVHKE	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43491	Band 4.1-like protein 2	LIG_APCC_ABBAyCdc20_2	990:996	RVVVHKE	APC,CDC20,FZR1	0.988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons